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"Estimating survival functions has interested statisticians for numerous years. A survival function gives information on the probability of a time-to-event of interest. Research in the area of survival analysis has increased greatly over the last several decades because of its large usage in areas related to biostatistics and the pharmaceutical industry. Among the methods which estimate the survival function, several are widely used and available in popular statistical software programs. One purpose of this research is to compare the efficiency between competing estimators of the survival function. Results are given for simulations which use nonparametric and parametric estimation methods on censored data. The simulated data sets have right-, left-, or interval-censored time points. Comparisons are done on various types of data to see which survival function estimation methods are more suitable. We consider scenarios where distributional assumptions or censoring type assumptions are violated. Another goal of this research is to examine the effects of these incorrect assumptions."--Abstract from author supplied metadata.
A concise summary of the statistical methods used in the analysis of survival data with censoring. Emphasizes recently developed nonparametric techniques. Outlines methods in detail and illustrates them with actual data. Discusses the theory behind each method. Includes numerous worked problems and numerical exercises.
This book collects and unifies statistical models and methods that have been proposed for analyzing interval-censored failure time data. It provides the first comprehensive coverage of the topic of interval-censored data and complements the books on right-censored data. The focus of the book is on nonparametric and semiparametric inferences, but it also describes parametric and imputation approaches. This book provides an up-to-date reference for people who are conducting research on the analysis of interval-censored failure time data as well as for those who need to analyze interval-censored data to answer substantive questions.
This monograph contains many ideas on the analysis of survival data to present a comprehensive account of the field. The value of survival analysis is not confined to medical statistics, where the benefit of the analysis of data on such factors as life expectancy and duration of periods of freedom from symptoms of a disease as related to a treatment applied individual histories and so on, is obvious. The techniques also find important applications in industrial life testing and a range of subjects from physics to econometrics. In the eleven chapters of the book the methods and applications of are discussed and illustrated by examples.
treated as random variables. Nonparametric estimates are found for the survival distribution, G(s) = P(S>s). The estimates can be computed using a General E-M Algorithm (Dempster et al (1977)). This method generalizes easily to left or right censored and tied data, and offers an alternative to the widely accepted Cox proportional hazards model. This approach yields a broadly applicable methodology for nonparametric estimation of the survival distribution.
Making complex methods more accessible to applied researchers without an advanced mathematical background, the authors present the essence of new techniques available, as well as classical techniques, and apply them to data. Practical suggestions for implementing the various methods are set off in a series of practical notes at the end of each section, while technical details of the derivation of the techniques are sketched in the technical notes. This book will thus be useful for investigators who need to analyse censored or truncated life time data, and as a textbook for a graduate course in survival analysis, the only prerequisite being a standard course in statistical methodology.
This book is meant for postgraduate modules that cover lifetime data in reliability and survival analysis as taught in statistics, engineering statistics and medical statistics courses. It is helpful for researchers who wish to choose appropriate models and methods for analyzing lifetime data. There is an extensive discussion on the concept and role of ageing in choosing appropriate models for lifetime data, with a special emphasis on tests of exponentiality. There are interesting contributions related to the topics of ageing, tests for exponentiality, competing risks and repairable systems. A special feature of this book is that it introduces the public domain R-software and explains how it can be used in computations of methods discussed in the book. Contents: Ageing; Some Parametric Families of Probability Distributions; Parametric Analysis of Survival Data; Nonparametric Estimation of the Survival Function; Tests of Exponentiality; Two Sample Nonparametric Problems; Proportional Hazards Model: A Method of Regression; Analysis of Competing Risks; Repairable Systems. Key Features Special emphasis on ageing and tests of exponentiality and their role in choosing appropriate models for lifetime data Extensive discussion of classical parametric and nonparametric models and relevant inference Documentation of new results in ageing, testing for competing risks and repairable systems Readership: Graduate students, academics and researchers in probability and statistics, industrial engineering, decision sciences and bioinformatics.
Interval-Censored Time-to-Event Data: Methods and Applications collects the most recent techniques, models, and computational tools for interval-censored time-to-event data. Top biostatisticians from academia, biopharmaceutical industries, and government agencies discuss how these advances are impacting clinical trials and biomedical research. Divided into three parts, the book begins with an overview of interval-censored data modeling, including nonparametric estimation, survival functions, regression analysis, multivariate data analysis, competing risks analysis, and other models for interval-censored data. The next part presents interval-censored methods for current status data, Bayesian semiparametric regression analysis of interval-censored data with monotone splines, Bayesian inferential models for interval-censored data, an estimator for identifying causal effect of treatment, and consistent variance estimation for interval-censored data. In the final part, the contributors use Monte Carlo simulation to assess biases in progression-free survival analysis as well as correct bias in interval-censored time-to-event applications. They also present adaptive decision making methods to optimize the rapid treatment of stroke, explore practical issues in using weighted logrank tests, and describe how to use two R packages. A practical guide for biomedical researchers, clinicians, biostatisticians, and graduate students in biostatistics, this volume covers the latest developments in the analysis and modeling of interval-censored time-to-event data. It shows how up-to-date statistical methods are used in biopharmaceutical and public health applications.