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Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery and the methodologies for carrying it out are brought together in a comprehensive work, Non-Clinical Vascular Infusion Technology, Two Volume Set: Science and Techniques. Volume I: The Science covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. It addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascular delivery as well as assessment of compatibility of the formulation with the dosing apparatus. Volume II: The Techniques builds upon the highly praised Handbook of Pre-Clinical Continuous Intravenous Infusion and provides a current account of the techniques and equipment involved in all the major laboratory animal species for conducting successful vascular infusion studies with xenobiotics. It is organized by species, including all those commonly used in pre-clinical studies: rat, mouse, dog, minipig, large primate, and marmoset. There are also chapters on juvenile studies and reproductive toxicity studies. Each section addresses the selection of the best model, surgical and non-surgical best practices, practical techniques, equipment selection, and commonly encountered background pathologies. Using a fresh approach, the authors identify best practices to be shared across the industry, and provide guidance on choices for the most acceptable methodologies from an animal welfare perspective. This two-volume set provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery.
Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. With contributions from an international selection of authors who are leaders in commercial infusion technology, Non-Clinical Vascular Infusion Technology, Volume II: The Techniquesprovides a current account of the techniques involved in all the major laboratory animal species for conducting successful vascular infusion studies with xenobiotics. Following in the footsteps of the highly praised Handbook of Pre-Clinical Continuous Intravenous Infusion, this new volume covers both up-to-date procedures and equipment. It is organized by species, including all those commonly used in pre-clinical studies: rat, mouse, dog, minipig, large primate, and marmoset. There are also chapters on juvenile studies and reproductive toxicity studies. Each section addresses the selection of the best model, surgical and non-surgical best practices, practical techniques, equipment selection, and commonly encountered background pathologies. Using a fresh approach, the authors identify best practices to be shared across the industry, and provide guidance on choices for the most acceptable methodologies from an animal welfare perspective. This volume, along with Volume I: The Science, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery. Features: Emphasizes best practices in accordance with the 3Rs--reduction, refinement, and replacement of animal usage in laboratories Presents step-by-step procedures and practical tips covering a wide range of common animal models, augmented by the liberal use of illustrations Covers modern practices and procedures in accordance with up-to-date equipment development
This two volume set covers the engineering and clinical benefits in diagnosis of human pathologies, including the protocols and potential of advanced tomography scanning with very high quality CT images. With contributions from world-class experts, the book examines all aspects of CT technologies related to neck-brain, cardiovascular systems, thorax, abdomen and GI system, pelvis and urinary system, and musculoskeletal system. It also provides coverage of CAD applications to CT along with a discussion of the potential dangers of CT in terms of over-radiation, particularly related to children.
The API (Association of Physicians of India) Textbook of Medicine consists of 28 sections across two comprehensive volumes covering a wide range of medical disorders. Fully revised and with 1588 images, illustrations and tables, this new edition has many new chapters on topics including nanotechnology and nano-medicine, and clinical approach to key manifestations. Each section is dedicated to a different medical phenomenon, including clinical pharmacology, endocrinology, dermatology, infectious diseases and nutrition. Also included is online access to teaching modules for teachers and students, questions and answers, an atlas/image bank, echocardiography and video EEG and common medical procedures with voice over.
Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication. Non-Clinical Vascular Infusion Technology, Volume I: The Sciencecovers the scientific principles behind the delivery systems, from both physical and physiological standpoints. The book addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascular delivery as well as assessment of compatibility of the formulation with the dosing apparatus. This volume, along with Volume II: The Techniques, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery. Features Identifies and shares best practices for non-clinical vascular infusion Presents modern practices and procedures in line with up-to-date equipment development Offers recommendations for in-life assessments in order to monitor the success or problems with the vascular infusion delivery Makes comparisons with human data in many areas
Encyclopedic, definitive, and state-of-the-art in the field of vascular disease and its medical, surgical, and interventional management, Rutherford's Vascular Surgery and Endovascular Therapy offers authoritative guidance from the most respected and innovative global thought leaders and clinical and basic science experts of our time. The thoroughly revised 10th Edition, published in association with the Society for Vascular Surgery and authored by multidisciplinary and international contributors, is an outstanding reference for vascular surgeons, vascular medicine specialists, interventional radiologists and cardiologists, and their trainees who depend upon Rutherford's in their practice. Under the expert editorial guidance of Drs. Anton N. Sidawy and Bruce A. Perler, it is quite simply the most complete and most reliable resource available on the art and science of circulatory diseases. - Incorporates fundamental vascular biology, diagnostic techniques, and decision making as well as medical, endovascular, and surgical treatment of vascular disease. - Features numerous concise and comprehensive diagnostic and therapeutic algorithms vital to patient evaluation and management. - Covers all vascular imaging techniques, offering a non-invasive evaluation of both the morphology and hemodynamics of the vascular system. - Employs a full-color layout, images and online videos, so readers can view clinical and physical findings and operative techniques more vividly. - Contains fully updated and more concise chapters with a focused format and summary for each that provides a quick access to key information—ideal for consultation as well as daily practice. - Includes expanded coverage of the business of vascular surgery, including a new section on the use of technology platforms and social media, and new chapters on telemedicine, the development and operation of outpatient dialysis centers and multispecialty cardiovascular centers, vascular information on the internet, and much more. - Provides new content on key topics such as endovascular treatment of complex aortic disease, acute vascular occlusion in the pediatric population, outpatient vascular care, and anatomic surgical exposures for open surgical reconstructions. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Now in full color, Principles and Practice of Veterinary Technology provides comprehensive coverage of the competencies every vet tech needs to know. Illustrated, step-by-step instructions emphasize the technician's role and responsibilities in each procedure, and dozens of new summary tables and boxes make it easy to find key information. Written by experienced vet tech educator Margi Sirois, this edition offers excellent preparation for clinical practice and for veterinary technician credentialing examinations. Comprehensive coverage includes the entire scope of competencies reflecting today's veterinary technology practice. 82 illustrated, step-by-step procedures include instructions for all AVMA-required psychomotor techniques. Clinical discussions of the technician's role are emphasized in every procedure. Expert authors are qualified vet tech educators who understand your needs and write in a clear, concise style. New Physical Therapy, Rehabilitation, and Complementary Medicine chapter helps you integrate physical rehabilitation, acupuncture, and herbal remedies into practice. Expanded coverage of exotics includes handling, restraint, and examination procedures for birds, reptiles, amphibians, and wildlife. Over 900 full-color photos and illustrations accurately depict specific disorders, diseases, and procedures, making these easier to learn. More tables and boxes summarize key information, to simplify the learning of complex material.
Cardiology’s cornerstone text – thoroughly updated to reflect the latest clinical perspectives and cutting-edge topics Hailed for its authority, currency, and ability to translate the latest technical and clinical advances into clinical application, Hurst’s The Heart is the field’s landmark text and cardiology’s longest continuously published reference text. A previous edition of this trusted classic was described by Doody’s as “an outstanding choice for those who strive for a firm foundation in cardiovascular medicine, as well as an up-to-date and user-friendly source that addresses every discipline in the field.” Readers will find succinct, visually appealing summaries of all the major new trials, and guidelines, along with tips for optimizing outcomes and health quality. The Fourteenth Edition has been completely updated to reflect the latest technical, therapeutic, and clinical advances, while still maintaining a strong focus on patient care. Other enhancements include the addition of textual features such as Practice Points, Common Clinical Questions, and an increased number of the acclaimed Hurst’s diagrams. • NEW TO THIS EDITION: Section on Metabolic Disorders and Cardiovascular Disease, Cigarette Smoking and Cardiovascular Disease • Enhanced by more than 1,500 full-color illustrations and more than 500 tables • Brand new chapters include: Arrythmogenic Cardiomyopathy, Ischemic Mitral Regurgitation, Degenerative Mitral Valve Disease, Left Ventricular Noncompaction, Evaluation and Management of Acute Heart Failure, Carotid Artery Stenting, Race, Ethnicity, and Cardiovascular disease • The only comprehensive cardiology reference to publish every 2.5 years to allow for reporting of the latest trials and guidelines
This reference places the latest information at users' fingertips, and a more streamlined format makes it easy to find the exact information quickly and conveniently. Includes access to a companion Web site for additional resources.
The trusted landmark cardiology resource—thoroughly updated to reflect the latest clinical perspectives Includes DVD with image bank A Doody's Core Title ESSENTIAL PURCHASE for 2011! 5 STAR DOODY'S REVIEW! "This is an outstanding choice for those who strive for a firm foundation in cardiovascular medicine, as well as an up-to-date and user-friendly source that addresses every discipline in the field. The updates and enhancements to this edition have made the book easier to use."--Doody's Review Service Through thirteen editions, Hurst’s the Heart has always represented the cornerstone of current scholarship in the discipline. Cardiologists, cardiology fellows, and internists from across the globe have relied on its unmatched authority, breadth of coverage, and clinical relevance to help optimize patient outcomes. The thirteenth edition of Hurst’s the Heart continues this standard-setting tradition with 19 new chapters and 59 new authors, each of whom are internationally recognized as experts in their respective content areas. Featuring an enhanced, reader-friendly design, the new edition covers need-to-know clinical advances, as well as issues that are becoming increasingly vital to cardiologists worldwide. As in previous editions, you will find the most complete overview of cardiology topics available—plus a timely new focus on evidence-based medicine, health outcomes, and health quality. New Features 1548 full-color illustrations and 578 tables Companion DVD with image bank includes key figures and tables from the text The Cardiovascular Disease: Past, Present, and Future section includes a new chapter on assessing and improving quality of care in cardiovascular medicine The section on the scientific foundations of cardiovascular medicine has been thoroughly revised 2 new chapters in the section on the evaluation of the patient detail the process of effective diagnostic decision making based on technology, clinical trials, and practice guidelines A new chapter in the section on heart failure details cardiac transplantation The sections on primary heart disease include new chapters on topics such as preventive strategies for coronary artery disease and updated pharmacologic strategies for acute coronary syndromes The section on cardiopulmonary disease features new chapters on chronic cor pulmonale and sleep disorder breathing and its relationship to cardiovascular disease The section on valvular heart disease has four of the six chapter completely rewritten by new authors who are authorities in the field The final six sections feature new chapters on the environment and heart disease, surgical treatment of carotid and peripheral vascular disease and cost effective strategies in cardiology