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Each year the Nobel Prizes in the natural sciences reveal amazing discoveries. Nominations are kept secret for 50 years after the awards have been made. Covering the awards from 1960 to 1962, this book reveals discoveries relating to the control of infectious diseases and the advent of organ transplant organs, as well as advances in molecular biology.
The present book discusses the Nobel Prizes in physiology or medicine 1966-68. The 1966 prize recognized that viruses may be involved in cancer formation. Later studies revealed that these kinds of infectious agents could pick up and transmit cellular genes of importance for regulation of cellular growth. It was then possible to recognize that many genes of this kind could be involved in the formation of cancer. The disease was found to represent the dark side of evolution. As a consequence of this insight new means of treatment fortunately have been developed.The rear parts of the eyes are extensions of the central nervous system. They have a fascinating intrinsic complexity, the neurophysiology and biochemistry of which has been progressively analyzed. These revealing studies concern both our capacity to distinguish different colors and also our possibility to see in the dark. The Prize in 1967 identified seminal contributions in this wide field by Ragnar Granit, Haldan Hartline and George Wald.The 1968 Prize is distinct in its recognition of Robert Holley, Ghobind Khorana and Marshall Nirenberg, who in different ways had contributed to the cracking of the genetic code. Insights into the language used by Nature, since the dawn of cellular life some 4.6 billion years ago, have completely revolutionized modern life sciences. The capacity to read and also to write the books of life has defined new kinds of science, deepening our understanding of the magic of evolution and opened the possibilities for molecular medicine by understanding the genetic background to diseases, not least cancer.Related Link(s)
This is the third book in a series presenting Nobel Prizes in life sciences using the remarkably rich archives of nominations and reviews which are kept secret for 50 years after the awards have been made. The two previous books are Nobel Prizes and Life Sciences (2010) and Nobel Prizes and Nature's Surprises (2013). The present book discusses the prizes in physiology or medicine 196365. The 1963 prize recognized milestone discoveries in the field of neurosciences, the way electrical impulses are generated and spread in nerves. The impressive developments of insights into tantalizing brain functions, like consciousness and memory, is discussed in the perspective of prizes both before and after the 1963 prize. The prize in 1964 marked the advanced biochemical venture that led to a full understanding of the synthesis of cholesterol, a central molecule for providing flexibility of the membranes of the trillions of cell in our body. The importance of this molecule for the appearance of cardiovascular diseases and the possibilities to prevent them is presented in the light of other prizes earlier and later in this field. The 1965 prize recognized three impressive French intellectuals, Lwoff, Monod and Jacob. Their contributions allowed the full maturation of the initial phase of the emerging field of molecular biology. The comprehension of the information flow from DNA via RNA to proteins was the source of a revolution of life sciences and of medicine.
An NPR Best Book of the Year An authoritative history of the race to unravel DNA’s structure, by one of our most prominent medical historians. James Watson and Francis Crick’s 1953 discovery of the double helix structure of DNA is the foundation of virtually every advance in our modern understanding of genetics and molecular biology. But how did Watson and Crick do it—and why were they the ones who succeeded? In truth, the discovery of DNA’s structure is the story of five towering minds in pursuit of the advancement of science, and for almost all of them, the prospect of fame and immortality: Watson, Crick, Rosalind Franklin, Maurice Wilkins, and Linus Pauling. Each was fascinating and brilliant, with strong personalities that often clashed. Howard Markel skillfully re-creates the intense intellectual journey, and fraught personal relationships, that ultimately led to a spectacular breakthrough. But it is Rosalind Franklin—fiercely determined, relentless, and an outsider at Cambridge and the University of London in the 1950s, as the lone Jewish woman among young male scientists—who becomes a focal point for Markel. The Secret of Life is a story of genius and perseverance, but also a saga of cronyism, misogyny, anti-Semitism, and misconduct. Drawing on voluminous archival research, including interviews with James Watson and with Franklin’s sister, Jenifer Glynn, Markel provides a fascinating look at how science is done, how reputations are undone, and how history is written, and revised. A vibrant evocation of Cambridge in the 1950s, Markel also provides colorful depictions of Watson and Crick—their competitiveness, idiosyncrasies, and youthful immaturity—and compelling portraits of Wilkins, Pauling, and most cogently, Rosalind Franklin. The Secret of Life is a lively and sweeping narrative of this landmark discovery, one that finally gives the woman at the center of this drama her due.
"Riveting."—Science A Forbes, Physics Today, Science News, and Science Friday Best Science Book Of 2018 Cosmologist and inventor of the BICEP (Background Imaging of Cosmic Extragalactic Polarization) experiment, Brian Keating tells the inside story of the mesmerizing quest to unlock cosmology’s biggest mysteries and the human drama that ensued. We follow along on a personal journey of revelation and discovery in the publish-or-perish world of modern science, and learn that the Nobel Prize might hamper—rather than advance—scientific progress. Fortunately, Keating offers practical solutions for reform, providing a vision of a scientific future in which cosmologists may finally be able to see all the way back to the very beginning.
The Nobel Prizes m natural sciences have achieved the reputation of being the ultimate accolade for scientific achievements. This honk gives a unique insight into the selection of Nobel Prize recipients, in particular the life sciences. The evolving mechanisms of selection of prize recipients are illustrated by reference to archives, which have remained secret for 1) years. Many of the prizes subjected to particular evaluation concern awards given for discoveries in the field of infectious diseases and the interconnected field of genetics. The book illustrates the individuals and environments that are conducive to scientific creativity. Nowhere is this enigmatic activity'-- the mime mover in advancing the human condition highlighted as lucidly as by identification individuals worthy of Nobel Prizes. --Book Jacket.
Many of the scientific breakthroughs of the twentieth century were first reported in the journal Nature. A Century of Nature brings together in one volume Nature's greatest hits—reproductions of seminal contributions that changed science and the world, accompanied by essays written by leading scientists (including four Nobel laureates) that provide historical context for each article, explain its insights in graceful, accessible prose, and celebrate the serendipity of discovery and the rewards of searching for needles in haystacks.
Does the universe embody beautiful ideas? Artists as well as scientists throughout human history have pondered this “beautiful question.” With Nobel laureate Frank Wilczek as your guide, embark on a voyage of related discoveries, from Plato and Pythagoras up to the present. Wilczek’s groundbreaking work in quantum physics was inspired by his intuition to look for a deeper order of beauty in nature. This is the deep logic of the universe—and it is no accident that it is also at the heart of what we find aesthetically pleasing and inspiring. Wilczek is hardly alone among great scientists in charting his course using beauty as his compass. As he reveals in A Beautiful Question, this has been the heart of scientific pursuit from Pythagoras and the ancient belief in the music of the spheres to Galileo, Newton, Maxwell, Einstein, and into the deep waters of twentieth-century physics. Wilczek brings us right to the edge of knowledge today, where the core insights of even the craziest quantum ideas apply principles we all understand. The equations for atoms and light are almost the same ones that govern musical instruments and sound; the subatomic particles that are responsible for most of our mass are determined by simple geometric symmetries. Gorgeously illustrated, A Beautiful Question is a mind-shifting book that braids the age-old quest for beauty and the age-old quest for truth into a thrilling synthesis. It is a dazzling and important work from one of our best thinkers, whose humor and infectious sense of wonder animate every page. Yes: The world is a work of art, and its deepest truths are ones we already feel, as if they were somehow written in our souls.
A refreshingly imaginative, daring debut collection of stories that illuminates with audacious wit the complexity of human behavior, and the veneer of civilization over our darkest urges. Told with perfect rhythm and unyielding brutality, these stories expose unsuspecting men and women to the realities of nature, the primal instincts of man, and the dark humor and heartbreak of our struggle to not only thrive, but survive. In "Girl on Girl," a high school freshman goes to disturbing lengths to help an old friend. An insatiable temptress pursues the one man she can't have in "Meteorologist Dave Santana." And in the title story, a long-fraught friendship comes undone when three buddies get impossibly lost on a lake it is impossible to get lost on. Below the quotidian surface of Diane Cook's worlds lurks an unexpected surreality that reveals our most curious, troubling, and bewildering behavior. Other stories explore situations pulled directly from the wild, imposing on human lives the danger, tension, and precariousness of the natural world: a pack of "not-needed" boys takes refuge in a murky forest where they compete against one another for their next meal; an alpha male is pursued through city streets by murderous rivals and desirous women; helpless newborns are snatched from their suburban yards by a man who stalks them. Through these characters Cook asks: What is at the root of our most heartless, selfish impulses? Why are people drawn together in such messy, needful ways? When the unexpected intrudes upon the routine, what do we discover about ourselves? As entertaining as it is dangerous, this accomplished collection explores the boundary between the wild and the civilized, where nature acts as a catalyst for human drama and lays bare our vulnerabilities, fears, and desires.
At the crossroads of philosophy and science, the sometimes-dry topics of evolution and ecology come alive in this new collection of essays--many never before anthologized. Learn how technology may be a sort of second nature, how the systemic human fungus Candida albicans can lead to cravings for carrot cake and beer, how the presence of life may be why there's water on Earth, and many other fascinating facts. The essay "Metametazoa" presents perspectives on biology in a philosophical context, demonstrating how the intellectual librarian, pornographer, and political agitator Georges Bataille was influenced by Russian mineralogist Vladimir Vernadsky and how this led to his notion of the absence of meaning in the face of the sun--which later influenced Jacques Derrida, thereby establishing a causal chain of influence from the hard sciences to topics as abstract as deconstruction and post-modernism. In "Spirochetes Awake" the bizarre connection between syphilis and genius in the life of Friedrich Nietzsche is traced. The astonishing similarities of the Acquired-Immune-Deficiency-Syndrome symptoms with those of chronic spirochete infection, it is argued, contrast sharply with the lack of evidence that "HIV is the cause of AIDS". Throughout these readings we are dazzled by the intimacy and necessity of relationships between us and our other planetmates. In our ignorance as "civilized" people we dismiss, disdain, and deny our kinship with the only productive life forms that sustain this living planet.