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Generalized hypermobility has been known since ancient times, and a clinical description of Ehlers-Danlos syndrome (EDS) is said to have first been recorded by Hippocrates in 400 BC. Hypermobility syndromes occur frequently, but the wide spectrum of possible symptoms, coupled with a relative lack of awareness and recognition, are the reason that they are frequently not recognized, or remain undiagnosed. This book is an international, multidisciplinary guide to hypermobility syndromes, and EDS in particular. It aims to create better awareness of hypermobility syndromes among health professionals, including medical specialists, and to be a guide to the management of such syndromes for patients and practitioners. It is intended for use in daily clinical practice rather than as a reference book for research or the latest developments, and has been written to be understandable for any healthcare worker or educated patient without compromise to the scientific content. The book is organized as follows: chapters on classifications and genetics are followed by chapters on individual types, organ (system) manifestations and complications, and finally ethics and therapeutic strategies, with an appendix on surgery and the precautions which should attend it. A special effort has been made to take account of the perspective of the patient; two of the editors have EDS. The book will be of interest to patients with hypermobility syndromes and their families, as well as to all those healthcare practitioners who may encounter such syndromes in the course of their work.
An Instant #1 New York Times Bestseller! A Publishers Weekly Bestseller! Leading actor, producer and director Channing Tatum's picture book debut, The One and Only Sparkella is a charming ode to self-esteem and the love between a father and daughter—illustrated by Kim Barnes. Ella is excited for her first day at a new school. Glimmering pencil case? Check! Shimmering backpack? Check! Glittery ribbons in her hair? Check! She can't wait to meet the other kids and share her sparkly personality. But her first day doesn't go quite as planned: Her new classmates don't like her disco-ball shoes, her PB&J-with-sprinkles sandwich, or her rainbow-y unicorn painting. Ella decides to try to be less sparkly at school the next day so the other kids won't make fun of her. But with a little help from her dad, she soon learns the importance of just being herself, no matter what other people say.
Selma Blair has played many roles: Ingenue in Cruel Intentions. Preppy ice queen in Legally Blonde. Muse to Karl Lagerfeld. Advocate for the multiple sclerosis community. But before all of that, Selma was known best as … a mean baby. In a memoir that is as wildly funny as it is emotionally shattering, Blair tells the captivating story of growing up and finding her truth. "Blair is a rebel, an artist, and it turns out: a writer."—Glennon Doyle, Author of the #1 New York Times Bestseller Untamed and Founder of Together Rising The first story Selma Blair Beitner ever heard about herself is that she was a mean, mean baby. With her mouth pulled in a perpetual snarl and a head so furry it had to be rubbed to make way for her forehead, Selma spent years living up to her terrible reputation: biting her sisters, lying spontaneously, getting drunk from Passover wine at the age of seven, and behaving dramatically so that she would be the center of attention. Although Selma went on to become a celebrated Hollywood actress and model, she could never quite shake the periods of darkness that overtook her, the certainty that there was a great mystery at the heart of her life. She often felt like her arms might be on fire, a sensation not unlike electric shocks, and she secretly drank to escape. Over the course of this beautiful and, at times, devasting memoir, Selma lays bare her addiction to alcohol, her devotion to her brilliant and complicated mother, and the moments she flirted with death. There is brutal violence, passionate love, true friendship, the gift of motherhood, and, finally, the surprising salvation of a multiple sclerosis diagnosis. In a voice that is powerfully original, fiercely intelligent, and full of hard-won wisdom, Selma Blair’s Mean Baby is a deeply human memoir and a true literary achievement.
In the late 1970s, Barbara Taylor, then an acclaimed young historian, began to suffer from severe anxiety. In the years that followed, Taylor's world contracted around her illness. Eventually, she was admitted to what had once been England's largest psychiatric institutions, the infamous Friern Mental Hospital in London
A 60-minute devised romp through the ins and outs of those excellently awkward first sexual encounters.
The invention of mass marketing led to cigarettes being emblazoned in advertising and film, deeply tied to modern notions of glamour and sex appeal. It is hard to find a photo of Humphrey Bogart or Lauren Bacall without a cigarette. No product has been so heavily promoted or has become so deeply entrenched in American consciousness. And no product has received such sustained scientific scrutiny. The development of new medical knowledge demonstrating the dire harms of smoking ultimately shaped the evolution of evidence-based medicine. In response, the tobacco industry engineered a campaign of scientific disinformation seeking to delay, disrupt, and suppress these studies. Using a massive archive of previously secret documents, historian Allan Brandt shows how the industry pioneered these campaigns, particularly using special interest lobbying and largesse to elude regulation. But even as the cultural dominance of the cigarette has waned and consumption has fallen dramatically in the U.S., Big Tobacco remains securely positioned to expand into new global markets. The implications for the future are vast: 100 million people died of smoking-related diseases in the 20th century; in the next 100 years, we expect 1 billion deaths worldwide.