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This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.
Supramolecular chemistry is the outburst topic of the next generation of science. While the majority of biomedical research efforts to date have centered on utilizing well-known polymeric materials, the recent progress in supramolecular chemistry has introduced a fascinating new field of macromolecular architecture. Supramolecular Design for Biological Applications focuses on modulating, altering, and mimicking biological functions with a new family of molecular assemblies. The authors provide innovative ideas and concepts for developing novel biomaterials that could be applied in diagnosis, drug carrier operations, and environmental protection. This reference is comprehensive, presenting principles, applications, recent advances, and future directions. Each chapter includes clear and informative illustrations of molecular architectures. The writing is scientific but allows for easy comprehension of the differences in molecular interactions, dimensions, and supramolecular architecture. Supramolecular Design for Biological Applications will advance the understanding of supramolecular-structured biomaterials and associated issues regarding biological functions. By explaining recent trends and molecular interactions, this book will enable you to initiate new research for nano-scale science and technology in the 21st century.
Supramolecular chemistry is ‘chemistry beyond the molecule’ - the chemistry of molecular assemblies and intermolecular bonds. It is one of today’s fastest growing disciplines, crossing a range of subjects from biological chemistry to materials science; and from synthesis to spectroscopy. Supramolecular Chemistry is an up-to-date, integrated textbook that tells the newcomer to the field everything they need to know to get started. Assuming little in the way of prior knowledge, the book covers the concepts behind the subject, its breadth, applications and the latest contemporary thinking in the area. It also includes coverage of the more important experimental and instrumental techniques needed by supramolecular chemists. The book has been thoroughly updated for this second edition. In addition to the strengths of the very popular first edition, this comprehensive new version expands coverage into a broad range of emerging areas. Clear explanations of both fundamental and nascent concepts are supplemented by up-to-date coverage of exciting emerging trends in the literature. Numerous examples and problems are included throughout the book. A system of “key references” allows rapid access to the secondary literature, and of course comprehensive primary literature citations are provided. A selection of the topics covered is listed below. Cation, anion, ion-pair and molecular host-guest chemistry Crystal engineering Topological entanglement Clathrates Self-assembly Molecular devices Dendrimers Supramolecular polymers Microfabrication Nanoparticles Chemical emergence Metal-organic frameworks Gels Ionic liquids Supramolecular catalysis Molecular electronics Polymorphism Gas sorption Anion-pinteractions Nanochemistry Supramolecular Chemistry is a must for both students new to the field and for experienced researchers wanting to explore the origins and wider context of their work. Review: "At just under 1000 pages, the second edition of Steed and Atwood's Supramolecular Chemistry is the most comprehensive overview of the area available in textbook form...highly recommended." —Chemistry World, August 2009
Perspectives in Supramolecular Chemistry relates recent developments and new exciting approaches in supramolecular chemistry. The series covers all areas from theoretical and modelling aspects through organic and inorganic chemistry and biochemistry to materials, solid-state and polymer sciences reflecting the many and varied applications of supramolecular structures in modern chemistry. From the early days of supramolecular chemistry the field has been associated with possible applications. This is not surprising as the design of new molecules, and later of assemblies of molecules, is often function-driven. Now, after three decades of supramolecular chemistry, David Reinhoudt has brought together a collection of reviews to reflect on the applications that have actually been achieved. The first applications in molecular recognition are now established technologies in analytical chemistry, separation science and medicine. More recently, developments have taken place in material design and these concepts are also discussed here. Contents * Self-Assembling Systems on Scales from Nanometers to Millimeters: Design and Discovery * Dendritic Architectures * Supramolecular Structures with Macromolecules * Chemosensors: Synthetic Receptors in Analytical Sensing Applications * Selective Ion Recognition with Durable Sensors * Ion Separations in Membrane and Solid Phase Extraction Systems * Porphyrin- and Expanded Pophyrin-Based Diagnostic and Therapeutic Agents Supramolecular Materials and Technologies illustrates the achievements and advances that supramolecular chemistry has made in many fields from organic chemistry to materials science and from analytical chemistry to molecular biology.
The aim of this book is to return to the biomimicry and medicinal potential that inspired many of the early supramolecular chemists and to set it in the context of current advances in the field. Following an overview of supramolecular chemistry, the first section considers the efforts made to synthesize artificial systems that mimic biological entities. The second section addresses the application of supramolecular principles to molecular diagnostics with a particular emphasis on the ‘receptor-relayreporter’ motif. Many of the examples chosen have clinical importance. The third section takes the clinical diagnostic theme further and demonstrates the therapeutic applications of supramolecular chemistry through photodynamic therapy, drug delivery, and the potential for synthetic peptides to form antibiotic tubes. The short epilogue considers the potential for supramolecular solutions to be found for further challenges in biomimetic and therapeutic chemistry.
The fundamentals of "supramolecular chemistry" to the latest developments on the subject are covered by this book. It sets out to explain the topic in a relatively easy way. The basic concepts of molecular recognition chemistry are included. Molecules with fascinating shapes and functions such as fullerenes, carbon nanotubes, dendrimers, rotaxane, and catenane, and molecular assemblies are also explained. Thereafter applications of supermolecules to nanotechnology are introduced with many examples of molecular devices. The last part of the book describes biological supermolecules and their mimics. Though simply explained undergraduate and graduate students in Chemistry will be able to use aspects of this work as an advanced textbook.
Supramolecular Chemistry: From Molecules to Nanomaterials is a new major reference work which links supramolecular chemistry and nanomaterials. Presenting over 150 tutorial articles and spanning over 10 comprehensive sections, this new resource covers: Concepts Techniques Molecular recognition Supramolecular reactivity Supramolecular aspects of chemical biology Self processes Supramolecular devices Supramolecular materials chemistry Soft matter Nanotechnology Supramolecular chemistry is 'chemistry beyond the molecule'. While traditional chemistry focuses on the bonds that hold atoms together in a molecule, supramolecular chemistry examines the weaker interactions that hold groups of molecules together. Important concepts that have been demonstrated by supramolecular chemistry include molecular self-assembly, folding, molecular recognition, host-guest chemistry, mechanically-interlocked molecular architectures, and dynamic covalent chemistry. The importance of supramolecular chemistry was established by the 1987 Nobel Prize for Chemistry, which was awarded to Donald J. Cram, Jean-Marie Lehn, and Charles J. Pedersen in recognition of their work in the field. The past decade has seen dramatic developments in the field, with supramolecular chemistry leaving its roots in classical host guest chemistry and expanding into exciting areas of materials chemistry and nanoscience with many real and potential applications. Supramolecular findings are evolving our understanding of the way chemical concepts at the molecular level build up into materials and systems with fascinating, emergent properties on the nanoscale. Supramolecular chemistry: the biggest challenge yet! "Creating that link between the chemist's understanding of the way in which molecules interact with one another, and the understanding a materials scientist, engineer or biologist has of the resulting properties of a material or system comprised of those molecules is one of the huge grand challenges facing modern molecular science." —Philip A. Gale and Jonathan W. Steed, Editors-in-Chief Linking supramolecular chemistry and nanotechnology to define the field in the 21st Century… Supramolecular Chemistry: From Molecules to Nanomaterials is the first major reference to link supramolecular chemistry and nanotechnology. A global team of experts present an overview of the concepts and techniques of modern supramolecular chemistry, demonstrating how these paradigms evolve into nanoscale systems chemistry, nanotechnology, materials science and beyond. Breaking down the barriers between synthetic chemistry and materials science, the authors demonstrate how modern techniques allow access increasingly far along the 'synthesising-up' pathway. Supramolecular Chemistry: From Molecules to Nanomaterials explains the fundamental concepts and provides invaluable practical guidance on the applications and limitations of modern instrumental techniques for addressing molecular and materials-based problems. The printed edition of Supramolecular Chemistry: From Molecules to Nanomaterials is available as an eight-volume set. Publishing in full colour to enhance the interpretation of complex supramolecular structures the printed edition is highly illustrated with an average of three images per page features fully indexed articles with cross-references integrated into the text includes a glossary of key terms Online Edition Supramolecular Chemistry: From Molecules to Nanomaterials is now available online. For further information visit WileyOnlineLibrary.com/ref/smc
This book investigates the latest developments in supramolecular assembly systems for mimicking biological structures and functions. Consisting of 14 chapters, it covers various assembly systems, such as polysaccharides, peptides, proteins, biopolymers, natural materials and various hybrid systems. Further, it focuses on different types of supramolecular systems with particular functions or structures that are relevant to living systems. A number of modern techniques used to study the supramolecular systems, such as total internal reflection fluorescence microscopy (TIRFM) and two-photon confocal microscopy, are also introduced in detail. Unlike conventional books on supramolecular assemblies, this book highlights the functions of the assembly systems, particularly their biological applications. As such, it offers a valuable resource for experienced researchers, as well as graduate students working in the field of supramolecular chemistry and biomimetic systems.
This first volume in the new Springer Series on Fluorescence brings together fundamental and applied research from this highly interdisciplinary and field, ranging from chemistry and physics to biology and medicine. Special attention is given to supramolecular systems, sensor applications, confocal microscopy and protein-protein interactions. This carefully edited collection of articles is an invaluable tool for practitioners and novices.