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A leading bioethicist offers critical insights into the scientific, ethical, and political implications of human genome editing. Designer babies, once found only in science fiction, have become a reality. We are entering a new era of human evolution with the advent of a technology called CRISPR, which allows scientists to modify our genes. Although CRISPR shows great promise for therapeutic use, it raises thorny ethical, legal, political, and societal concerns because it can be used to make permanent changes to future generations. What if changes intended for the good turn out to have unforeseen negative effects? What if the divide between the haves and have-nots widens as a result? Who decides whether we genetically modify human beings and, if so, how? Françoise Baylis insists that we must all have a role in determining our future as a species. The scientists who develop and use genome-editing tools should not be the only ones making decisions about future uses of the technology. Such decisions must be the fruit of a broad societal consensus. Baylis argues that it is in our collective interest to assess and steer the development and implementation of biomedical technologies. Members of the public with different interests and diverse perspectives must be among the decision makers; only in this way can we ensure that societal concerns are taken into account and that responsible decisions are made. We must be engaged and informed, think critically, and raise our voices as we create our future together. Sharp, rousing, timely, and thought-provoking, Altered Inheritance is essential reading. The future of humanity is in our hands.
Drawing on startling new evidence from the mapping of the genome, an explosive new account of the genetic basis of race and its role in the human story Fewer ideas have been more toxic or harmful than the idea of the biological reality of race, and with it the idea that humans of different races are biologically different from one another. For this understandable reason, the idea has been banished from polite academic conversation. Arguing that race is more than just a social construct can get a scholar run out of town, or at least off campus, on a rail. Human evolution, the consensus view insists, ended in prehistory. Inconveniently, as Nicholas Wade argues in A Troublesome Inheritance, the consensus view cannot be right. And in fact, we know that populations have changed in the past few thousand years—to be lactose tolerant, for example, and to survive at high altitudes. Race is not a bright-line distinction; by definition it means that the more human populations are kept apart, the more they evolve their own distinct traits under the selective pressure known as Darwinian evolution. For many thousands of years, most human populations stayed where they were and grew distinct, not just in outward appearance but in deeper senses as well. Wade, the longtime journalist covering genetic advances for The New York Times, draws widely on the work of scientists who have made crucial breakthroughs in establishing the reality of recent human evolution. The most provocative claims in this book involve the genetic basis of human social habits. What we might call middle-class social traits—thrift, docility, nonviolence—have been slowly but surely inculcated genetically within agrarian societies, Wade argues. These “values” obviously had a strong cultural component, but Wade points to evidence that agrarian societies evolved away from hunter-gatherer societies in some crucial respects. Also controversial are his findings regarding the genetic basis of traits we associate with intelligence, such as literacy and numeracy, in certain ethnic populations, including the Chinese and Ashkenazi Jews. Wade believes deeply in the fundamental equality of all human peoples. He also believes that science is best served by pursuing the truth without fear, and if his mission to arrive at a coherent summa of what the new genetic science does and does not tell us about race and human history leads straight into a minefield, then so be it. This will not be the last word on the subject, but it will begin a powerful and overdue conversation.
Every family has secrets; only some secrets are lethal. In Victoria Costello’s family mental illness had been given many names over at least four generations until this inherited conspiracy of silence finally endangered the youngest members of the family, her children. In this riveting story—part memoir, detective story, and scientific investigation—the author recounts how the mental unraveling of her seventeen-year-old son Alex compelled her to look back into family history for clues to his condition. Eventually she tied Alex’s descent into hallucinations and months of shoeless wandering on the streets of Los Angeles to his great grandfather’s suicide on a New York City railroad track in 1913. But this insight brought no quick relief. Within two years of Alex’s diagnosis of paranoid schizophrenia, both she and her youngest son succumbed to two different mental disorders: major depression and anxiety disorder. Costello depicts her struggle to get the best possible mental health care for her sons and herself, treatment that ultimately brings each of them to full recovery. In the process, she discovers new science that explains how clusters of mental illness traverse family generations. Artfully weaving the scientific into the personal, Costello takes a journey to the far reaches of neuroscience and reports back on the startling findings it is yielding about the complex interplay between genes and environment that drives mental illness, and what it now tells us about how parents can trump a lethal inheritance. She shares the results of long-term U.K. and European family studies identifying the earliest signs of mental illnesses that can be passed on from grandparents to parents and grandchildren. She tracks ongoing clinical trials to reverse the courses of these diseases through early intervention with the latest evidence-based treatments and offers brain-healthy choices individuals and families can make to prevent mental illness—freeing future generations to live healthier, happier lives.
Bonduriansky and Day challenge the premise that genes alone mediate the transmission of biological information across generations and provide the raw material for natural selection. They explore the latest research showing that what happens during our lifetimes--and even our parents' and grandparents' lifetimes--can influence the features of our descendants. Based on this evidence, Bonduriansky and Day develop an extended concept of heredity that upends ideas about how traits can and cannot be transmitted across generations, opening the door to a new understanding of inheritance, evolution, and even human health. --Adapted from publisher description.
In Inheritance of Loss, anthropologist Yukiko Koga tackles complex questions of how two nations previously at war come to terms with their troubled past. Her site is Northeast China, where Japan s imperial ambitions were pursued to devastating and murderous ends in the twentieth century. There the landscape, which is still peppered with missiles and unexploded chemical weapons from the war, is the backdrop for refurbished imperial architecture and revived Japanese businesses. But the national wounds of China and Japan s history problem cannot be stitched together solely through international trade. The author shows why mutual recognition of wartime atrocities is the only thing that can allay the persistent and sporadically explosive tensions between two of the most powerful countries in the Eastern hemisphere. A milestone in memory studies that incorporates sorely needed attention to materiality and political economy, Inheritance of Loss shows just how crucial imperial legacies will continue to be despite China s and Japan s attempts to leave the past behind in pursuit of a more prosperous future."
This award winning book offers kids an authentic depiction of selective mutism and a story of the experience of middle school interactions and mental illness. Elise carries a notebook full of tallies, each page marking a day spent at her new public school, each stroke of her pencil marking a word spoken. A word that can't be taken back. Five tally marks isn't so bad. Two is pretty good. But zero? Zero is perfect. Zero means no wrong answers called out in class, no secrets accidentally spilled, no conversations to agonize over at night when sleep is far away. But now months have passed, and Elise isn't sure she could speak even if she wanted to—not to keep her only friend, Mel, from drifting further away—or to ask if anyone else has seen her English teacher's stuffed raven come to life. Then, the discovery of a shocking family secret helps Elise realize that her silence might just be the key to unlocking everything she's ever hoped for... A 2019 Notable Children's Books in the Language Arts (NCTE) A 2018 Cybils Nominee A Texas Lone Star Reading List title "Powerful and poetic."—John David Anderson, author of Posted and Ms. Bixby's Last Day "This tender and truthful book stays with you long after the words have gone."—Patricia Forde, author of The List "A must read. After Zero reminds us of so many loved ones of those suffering from anxiety or depressive disorders. It is a story that will hopefully foster empathy and maybe even communication with our 'quiet' peers."—Wesley King, author of OCDaniel Age Level: 8 and up | Grade Level: 3 to 7 Great for parents and educators looking for: A story that addresses middle school social interactions, grief, loss and mental illness A story that depicts selective mutism authentically
Eileen Spring presents a fresh interpretation of the history of inheritance among the English gentry and aristocracy. In a work that recasts both the history of real property law and the history of the family, she finds that one of the principal and determinative features of upper-class real property inheritance was the exclusion of females. This exclusion was accomplished by a series of legal devices designed to nullify the common-law rules of inheritance under which--had they prevailed--40 percent of English land would have been inherited or held by women. Current ideas of family development portray female inheritance as increasing in the seventeenth and eighteenth centuries, but Spring argues that this is a misperception, resulting from an incomplete consideration of the common-law rules. Female rights actually declined, reaching their nadir in the eighteenth century. Spring shows that there was a centuries-long conflict between male and female heirs, a conflict that has not been adequately recognized until now.
The law of succession rests on a single brute fact: you can't take it with you. The stock of wealth that turns over as people die is staggeringly large. In the United States alone, some $41 trillion will pass from the dead to the living in the first half of the 21st century. But the social impact of inheritance is more than a matter of money; it is also a matter of what money buys and brings about. Law and custom allow people many ways to pass on their property. As Friedman's enlightening social history reveals, a decline in formal rules, the ascendancy of will substitutes over classic wills, social changes like the rise of the family of affection, changing ideas of acceptable heirs, and the potential disappearance of the estate tax all play a large role in the balance of wealth. Dead Hands uncovers the tremendous social and legal importance of this rite of passage, and how it reflects changing values and priorities in American families and society.
This gripping story of the doctors at the forefront of Alzheimer’s research and the courageous North Dakota family whose rare genetic code is helping to understand our most feared diseases is “excellent, accessible...A science text that reads like a mystery and treats its subjects with humanity and sympathy” (Library Journal, starred review). Every sixty-nine seconds, someone is diagnosed with Alzheimer’s disease. Of the top ten killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer’s, an inherited genetic mutation that causes the disease in one hundred percent of cases, and has a fifty percent chance of being passed onto the next generation. Of the six DeMoe children whose father had it, five have inherited the gene; the sixth, daughter Karla, has inherited responsibility for all of them. But rather than give up in the face of such news, the DeMoes have agreed to spend their precious, abbreviated years as part of a worldwide study that could utterly change the landscape of Alzheimer’s research and offers the brightest hope for future treatments—and possibly a cure. Drawing from several years of in-depth research with this charming and upbeat family, journalist Niki Kapsambelis tells the story of Alzheimer’s through the humanizing lens of these ordinary people made extraordinary by both their terrible circumstances and their bravery. “A compelling narrative…and an educational and emotional chronicle” (Kirkus Reviews, starred review), their tale is intertwined with the dramatic narrative history of the disease, the cutting-edge research that brings us ever closer to a possible cure, and the accounts of the extraordinary doctors spearheading these groundbreaking studies. From the oil fields of North Dakota to the jungles of Colombia, this inspiring race against time redefines courage in the face of this most pervasive and mysterious disease.
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