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Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.
In Fragile Brains Kathleen Taylor looks at the genetic and lifestyle factors currently linked to the development of dementia, focusing on important new research on how the immune system operates in the brain.
In step with our growing lifespan, dementia is becoming a widespread handicap to the health and well-being of individuals and a burden on human society world-wide. The increasing prevalence of this tragic condition has stimulated an explosion of scientific research in the last ten years, which resulted in numerous profound insights and technical innovations. This timely volume presents both an overall and a detailed overview of the current worldwide knowledge about the neuroscientific basis of dementia. Leading authorities in their fields provide a far-reaching synthesis of all topics in dementia research, including pathogenesis of dementia, neuroimaging of the earliest alterations, potential biological and genetic markers for Alzheimer`s Disease and new therapeutic strategies. Each chapter discusses clinical implications and areas of controversy, highlights the wide range of current and future therapeutic possibilities and indicates promising directions for further research...
This care manual covers a wide range of information in a short, easily accessible handbook format. It follows the pathway of dementia, from first presentation through to final stages of the illness, and is aimed at the multipdisciplinary care team.
Possible new breakthroughs in understanding the aging mind that can be used to benefit older people are now emerging from research. This volume identifies the key scientific advances and the opportunities they bring. For example, science has learned that among older adults who do not suffer from Alzheimer's disease or other dementias, cognitive decline may depend less on loss of brain cells than on changes in the health of neurons and neural networks. Research on the processes that maintain neural health shows promise of revealing new ways to promote cognitive functioning in older people. Research is also showing how cognitive functioning depends on the conjunction of biology and culture. The ways older people adapt to changes in their nervous systems, and perhaps the changes themselves, are shaped by past life experiences, present living situations, changing motives, cultural expectations, and emerging technology, as well as by their physical health status and sensory-motor capabilities. Improved understanding of how physical and contextual factors interact can help explain why some cognitive functions are impaired in aging while others are spared and why cognitive capability is impaired in some older adults and spared in others. On the basis of these exciting findings, the report makes specific recommends that the U.S. government support three major new initiatives as the next steps for research.
Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or delay these conditions has been limited at best, despite the many claims of success made in popular media and advertising. Today, however, a growing body of prevention research is emerging. Preventing Cognitive Decline and Dementia: A Way Forward assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. This report provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging.
This thoroughly revised new edition of a classic book provides a clinically inspired but scientifically guided approach to the biological foundations of human mental function in health and disease. It includes authoritative coverage of all the major areas related to behavioral neurology, neuropsychology, and neuropsychiatry. Each chapter, written by a world-renowned expert in the relevant area, provides an introductory background as well as an up-to-date review of the most recent developments. Clinical relevance is emphasized but is placed in the context of cognitive neuroscience, basic neuroscience, and functional imaging. Major cognitive domains such as frontal lobe function, attention and neglect, memory, language, prosody, complex visual processing, and object identification are reviewed in detail. A comprehensive chapter on behavioral neuroanatomy provides a background for brain-behavior interactions in the cerebral cortex, limbic system, basal ganglia, thalamus, and cerebullum. Chapters on temperolimbic epilepsy, major psychiatric syndromes, and dementia provide in-depth analyses of these neurobehavioral entities and their neurobiological coordinates. Changes for this second edition include the reflection throughout the book of the new and flourishing alliance of behavioral neurology, neuropsychology, and neuropsychiatry with cognitive science;major revision of all chapters; new authorship of those on language and memory; and the inclusion of entirely new chapters on psychiatric syndromes and the dementias. Both as a textbook and a reference work, the second edition of Principles of Behavioral and Cognitive Neurology represents an invaluable resource for behavioral neurologists, neuropsychologists, neuropsychiatrists, cognitive and basic neuroscientists, geriatricians, physiatrists, and their students and trainees.
New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.
Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. - Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics - Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology - Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications
Distils the most valuable discoveries in dementia research into clear, insightful chapters written by international experts.