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Saliva is essential for oral health and influences all events in the mouth. In 1850 Ludwig discovered that autonomic nerve impulses evoke salivary secretion and all work since has shown that the nerves normally control the flow and protein output of saliva. This publication, written by international experts, is the first one devoted to the neuroglandular mechanisms of this control. The book lays a sound platform of knowledge to all with an interest in and around the mouth including dentists, doctors, pharmacologists, biochemists and cell biologists as well as neurobiologists working on autonomic nerve activities.
This volume aims to give a comprehensive overview of the cellular mechanisms underlying the process of secretion in vertebrate, particularly mammalian, exocrine glands. The subject matter is divided into two sections. The first section deals with general aspects of secretion, including chapters on the roles of ion channels in secretion. Signal transduction is also covered, and several chapters deal with recently developed investigative techniques that offer promise as tools for the further investigation of exocrine secretory processes. The second section deals with secretion in a selection of exocrine organs: salivary glands, lacrimal glands, the pancreas, gastric mucosa, liver, epididymis, and vertebrate salt glands. A final chapter deals with cystic fibrosis, the common, fatal, inherited disease, which affects exocrine glands particularly severely.
Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choic
Saliva is essential for oral health and influences all events in the mouth. A deficiency of saliva can have devastating consequences. Therefore, it is important to have a book about the basic tissue mechanisms involved in the secretion of saliva, based on an holistic approach. With such an aim in mind, this book contains chapters covering the histological basis for secretion, electrophysiological events, electrolyte and water secretion, protein synthesis and secretion, bloodflow, capillary dynamics, myoepithelial activity, glandular permeability, hormonal influences, including the effects of diabetes, and the synthesis and secretion of IgA in man. The chapters have been written by international experts in the field, who present balanced accounts of their subjects. The secretory mechanisms described in this book have a far-reaching impact beyond the salivary field and have applicability to all forms of exocrine secretion. Salivary glands offer many advantages for experimental study of these phenomena since they can be tested more precisely than most other glands, having ducts that can readily be cannulated for assessing the secretion. As a single-source of up-to-date data, this book will benefit doctors and dentists, and anyone interested in secretory phenomena, including physiologists, biochemists and cell biologists. It not only brings together all available data on this subject, as it stands at the turn of the century, but also lays down a sound platform of knowledge on which further investigations can be based.
Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.
Eating is defined as the act of taking food into the mouth, chewing and then swallowing it for nourishment. The purpose of this volume is to present a number of up-to-date scientific reviews on the mechanisms involved in the process of eating and to introduce the reader to some of the problems encountered when these complex processes malfunction. Topics include a discussion on the peripheral mechanisms of taste and smell, taste and olfactory processing in the brain and its relation to the control of eating, and a section on mastication with an account of the scientific basis of masticatory disorders. The control mechanisms involved in salivation and swallowing are also extensively reviewed. Because this book reviews the fundamental understanding of the physiological mechanisms involved in eating and includes an insight into the scientific basis of the malfunction of these mechanisms, it will be of equal value to both clinical and basic scientists. In particular, basic and clinical oral biologists and neurophysiologists, dental and medical researchers and postgraduate students will find it a valuable source of information.
This overview of autonomic pharmacology describes the anatomy, physiology and pharmacology of the autonomic involuntary nervous system. Covering the diverse group of drugs acting on the autonomous nervous system, their actions are reviewed together with their clinical uses, side effects, interactions and subcellular mechanisms of action. Information is organized in a logical flow, bringing together the latest advances in an integrated form on topics usually found only in a fragmented form.; This work is intended for all those researching in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry and molecular biology.