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This important subject of Diagnosis of and Treatment for Neurobehavioral manifestations of neurologic disease is directed by three leaders of this field - Dr. Alizeza Minagar, Dr. Glen Finney, and Dr. Kenneth Heilman. Topics include: Neurobehavioral testing for mental status; Behavioral neurology of vascular neurology; Alzheimer's disease; Frontotemporal dementia; Traumatic brain injury; Parkinsonian Syndromes (e.g., Parkinson's disease, Lewy body dementia, progressive supranuclear palsy, corticobasal disease, multisystem atrophy); Behavioral neurology of multiple sclerosis and autoimmune encephalopathies; Infectious Diseases (Neuro-AIDS, Neurosyphilis, HSV); Neurobehavioral aspects of systemic disease; Neurobehavioral aspects of epilepsy; Behavioral neurology aspects of nutritional deficiencies; Neurobehavioral aspects of mitochondrial disease; and Medicinal-induced behavioral disorders.
Dr. Richard Barohn and Dr. Mazen Dimachkie lead this publication on Motor Neuron Disease. Focus is on ALS, with inclusion of primary lateral sclerosis, primary muscular atrophy, leg amyotrophic diplegia, brachial amyotropic diplegia, and isolate bulbar ALS. Among the topics presented are. Patterns of weakness, classification of motor neuron disease & clinical diagnosis of sporadic ALS; Potential environmental factors in ALS; Neuropathology; Spinal muscular atrophy; Complementary and alternative therapies in ALS frontotemporal dysfunction and dementia in ALS; Symptoms management and end of life care; Research approaches to slowing progression of ALS; Familial ALS; Kennedy disease and more. Information in this issue presents: Description of the problem (Incidence, Prevalence, Severity, Natural history); 2. Review of pertinent data; Controversial areas discussing aspects such as areas of practice for which there are disagreements and why? What are the arguments and counter arguments and what data support them?; Conclusions using levels of clinical evidence that support or refute an intervention. Procedural steps are provided for diagnostic and treatment discussions along with clinical cases.
This issue of the Neurologic Clinics is being edited by the series Consulting Editor, Dr. Randolph Evans, and will be a special issue focusing on patient case studies of a board range of neurological diseases and disorders. Topics and cases covered include, but are not limited to: cerebrovascular disease, multiple sclerosis, syncope, epilepsy, tremor, dementia, neurologic issues in pregnancy, and medicolegal cases.
Cerebrovascular disease results in huge health expenditures, multiple recurring physician visits, and a great number of surgical and non-surgical treatments along with research into causes and prevention. This issue addresses therapies, early therapies, diagnoses, and prevention. Topics include: Endovascular Treatment of Acute Ischemic Stroke; Acute Treatment of Blood Pressure after Ischemic Stroke and Intracerebral Hemorrhage; Diagnostic Evaluation for Non-traumatic Intracerebral Hemorrhage; Prevention of Recurrent Stroke in Patients with Patent Foramen Ovale; Management of Asymptomatic Carotid Stenosis; Stenting or Endarterectomy for Patients with Symptomatic Carotid Stenosis; The Therapeutic Value of Laboratory Testing for Hypercoagulable States in Secondary Stroke Prevention; Diagnosis and Treatment of Carotid and Vertebral Artery Dissection; Recurrent Stroke while on Anti-platelet Therapy; Anti-platelet and Anti-coagulant Therapy after Intracerebral Hemorrhage; Diagnosis and Treatment of Isolated Central Nervous System Angiitis/Vasculitis; Statins for Aneurysmal Subarachnoid Hemorrhage; Expansion of IV-tPA eligibility beyond NINDS and ECASS III criteria; and Treatment of Unruptured Arteriovenous Malformations. William J Powers MD, renowned for his clinical work with Stroke and Research in Cerebral blood flow and metabolism, and stroke treatment and prevention, leads this issue of Neurologic Clinics, with authors renown in the field.
Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. - The first focused reference specifically on alcohol and the brain - Details our current understanding of how alcohol impacts the central nervous system - Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse - Includes section on neuroimaging of neurochemical markers and brain function
This common and very important disorder of Epilepsy is led by Dr. Steven Schachter in this issue of Neurologic Clinics. The majority of articles review methods for application of standards, guidelines, and consensus statement to clinical practice by Primary Care physicians and general Neurologists using validated and evidence-based tools such as screening instruments and algorithms for a number of critically important topics, ranging from initial evaluation to monitoring patients on treatment to counseling and educating patients on SUDEP and driving. Topics in this issue include: Guidelines and quality standards for adult epilepsy patients; Guidelines and quality standards in care of children with epilepsy; Initial evaluation of the patient with suspected epilepsy; Starting, choosing, changing, and discontinuing treatment; Methods for measuring seizure frequency and severity; Assessment of treatment side effects and quality of life; Screening for depression and anxiety; Counseling patients on driving and employment; Issues for women with epilepsy; Patient education (SUDEP - Sudden Unexpected Death in Epilepsy; Self-management; Adherence; Rescue medication); Optimizing the patient-physician therapeutic alliance.
The focus of this publication on Neuro-Otology in Neurologic Clinics is on the patient presenting for urgent or emergent care with a chief complaint of new, previously-undiagnosed dizziness or vertigo. Intent is to emphasize throughout the issue five primary components of initial diagnosis and management: (1) Epidemiology, differential diagnosis, and disease definitions; (2) Bedside clinical features that differentiate dangerous from benign causes; (3) Appropriate use of advanced diagnostic tests (including imaging, vestibular tests) and consultations; (4) Application of early treatments (manipulative, pharmacologic, rehabilitative); and (5) Acute disposition strategies, including determining need for admission and urgency of follow-up. Articles have a consistent architecture to highlight key points: 1) Case Scenario (with a representative case example; videos are presented with many of these); 2) Prevalence & Pathomechanisms; 3) Definitions & Diagnostic Criteria; 4) Bedside & Laboratory Diagnostic Tests; 5) Acute Treatment Options (including manipulative, pharmacologic, rehabilitative); and 6) Triage & Disposition (including referrals and follow-up). The articles are presented with four major parts: Overall approach to acute dizziness and vertigo; Episodic vertigo and dizziness; Acute, continuous vertigo and dizziness; and Case unknowns. Among the topics covered are: Bedside evaluation; Transient ischemic attacks; Vestibularl neuritis and labyrinthitis; Stroke; Novel approach to diagnosing the acutely dizzy patient. David Newman-Toker leads this publication with associate editors renown in their fields - Kevin Kerber, William J. Meurer, Rodney Omron, and Jonathan Edlow.
This issue of Neurologic Clinics, edited by Dr. David Younger, is focused on Global and Domestic Public Health and Neuroepidemeiology. Topics covered in the issue include, but are not limited to research methods; gene-environment interplay; Alzheimer disease; headache disorders; multiple sclerosis and related disorders; lyme neuroborreliosis; cerebrovascular disease; neuro-oncology; community health needs assessment; and neurologic public health in the BRICS.
Brain disordersâ€"neurological, psychiatric, and developmentalâ€"now affect at least 250 million people in the developing world, and this number is expected to rise as life expectancy increases. Yet public and private health systems in developing countries have paid relatively little attention to brain disorders. The negative attitudes, prejudice, and stigma that often surround many of these disorders have contributed to this neglect. Lacking proper diagnosis and treatment, millions of individual lives are lost to disability and death. Such conditions exact both personal and economic costs on families, communities, and nations. The report describes the causes and risk factors associated with brain disorders. It focuses on six representative brain disorders that are prevalent in developing countries: developmental disabilities, epilepsy, schizophrenia, bipolar disorder, depression, and stroke. The report makes detailed recommendations of ways to reduce the toll exacted by these six disorders. In broader strokes, the report also proposes six major strategies toward reducing the overall burden of brain disorders in the developing world.
This manual takes a multidisciplinary approach to neurological disorders in the elderly. Comprehensive and practical, it includes the most recent diagnostic criteria and immediately accessible visual care paths including the latest pharmacologic and non-pharmacologic interventions. Covering a range of modalities, from the importance and impact of each disease to diagnostic criteria, genetics, laboratory and imaging findings, treatment and care paths, this book focuses on neurological conditions that occur commonly in older persons or which have a striking effect on their lives. The common types of dementias, Parkinson’s disease and related disorders, rapidly progressive diseases, seizure disorders and multiple sclerosis are covered. Issues commonly affecting this population, such as neurobehavioral symptoms and caregiver issues, are discussed. Neuro-Geriatrics: A Clinical Manual is aimed at any physician who treats the elderly with neurological disorders: neurologists, geriatricians and geriatric psychiatrists, both specialists and general practitioners.