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An estimated 11,000 spinal cord injuries occur each year in the United States and more than 200,000 Americans suffer from maladies associated with spinal cord injury. This includes paralysis, bowel and bladder dysfunction, sexual dysfunction, respiratory impairment, temperature regulation problems, and chronic pain. During the last two decades, longstanding beliefs about the inability of the adult central nervous system to heal itself have been eroded by the flood of new information from research in the neurosciences and related fields. However, there are still no cures and the challenge of restoring function in the wake of spinal cord injuries remains extremely complex. Spinal Cord Injury examines the future directions for research with the goal to accelerate the development of cures for spinal cord injuries. While many of the recommendations are framed within the context of the specific needs articulated by the New York Spinal Cord Injury Research Board, the Institute of Medicine's panel of experts looked very broadly at research priorities relating to future directions for the field in general and make recommendations to strengthen and coordinate the existing infrastructure. Funders at federal and state agencies, academic organizations, pharmaceutical and device companies, and non-profit organizations will all find this book to be an essential resource as they examine their opportunities.
Brain Protection Strategies and Nanomedicine, Volume 266 in the Progress in Brain Research serial highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Histamine H3 and H4 receptors modulate Parkinson’s disease induced brain pathology: Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy, Ultra Early Molecular Biologic Diagnosis Of Malignant And Neurodegenerative Diseases By The Immunospecific Profiles Of The Proteins Markers Of The Surface Of The Mobilized Autologous Hematopoietic Stem Cells, Neuroprotective effects of Insulin like growth factor-1 on Engineered metal Nanoparticles Ag, Cu and Al induced blood-brain barrier breakdown, and more. Other chapters cover how Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude: Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51, Effectiveness of bortezomib and temozolomide for eradication of recurrent human glioblastoma cells, resistant to radiation, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research serials Includes the latest information on brain protection strategies and nanomedicine
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment
Presents the most up-to-date clinical and experimental research in neurotrauma in an illustrated, accessible, comprehensive volume.
Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the field of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for the TBI, clinical research professionals, researchers, medical and graduate students, and nurse specialists.
The spinal cord is comprised of four types of neurons: motor neurons, pre-ganglionic neurons, ascending projection neurons, and spinal interneurons. Interneurons are neurons that process information within local circuits, and have an incredible ability for neuroplasticity, whether due to persistent activity, neural injury, or in response to disease. Although, by definition, their axons are restricted to the same structure as the soma (in this case the spinal cord), spinal interneurons are capable of sprouting and rewiring entire neural circuits, and contribute to some restoration of disrupted neural communication after injury to the spinal cord (i.e., "bypassing the lesion site). Spinal Interneurons provides a focused overview of how scientists classify interneurons in general, the techniques used to identify subsets of interneurons, their roles in specific neural circuits, and the scientific evidence for their neuroplasticity. Understanding the capacity for neuroplasticity and identity of specific spinal interneurons that are optimal for recovery, may help determine cellular candidates for developing therapies. Spinal Interneurons provides neuroscientists, clinicians, and trainees a reference book exclusively concentrating on spinal interneurons, the techniques and experiments employed to identify and study these cells as part of normal and compromised neural circuits, and highlights the therapeutic potential of these cells by presenting the relevant pre-clinical and clinical work to date. People in industry will also benefit from this book, which compiles the latest in therapeutic strategies for targeting spinal interneurons, what considerations there are for the development and use of treatments, and how such treatments can not only be translated to the clinic, but how existing treatments should be appropriately reverse-translated to the bench. - Comprehensive overview of techniques used to identify, characterize, and classify spinal interneurons and their role in neural circuits - Description of the role that spinal interneurons play in mediating plasticity after compromise to spinal neural networks - In-depth discussion of therapeutic potential of spinal interneurons for spinal cord injury and/or disease