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Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.
An edited collection from some of the most influential writers in mental health. Books in the Norton Series on Interpersonal Neurobiology have collectively sold close to 1 million copies and contributed to a revolution in cutting-edge mental health care. An interpersonal neurobiology of human development enables us to understand that the structure and function of the mind and brain are shaped by experiences, especially those involving emotional relationships. Here, the three series editors have enlisted some of the most widely read IPNB authors to reflect on the impact of IPNB on their clinical practice and offer words of wisdom to the hundreds of thousands of IPNB-informed clinicians around the world. Topics include: Dan Hill on dysregulation and impaired states of consciousness; Bonnie Badenoch on therapeutic presence; Kathy Steele on motivational systems in complex trauma.
As scientific knowledge grows about the role of the brain in mental disorder, no clinician can afford to be uninformed about neurobiology. This accessible primer provides the basic grounding in neuroscience that all contemporary mental health professionals need. Readers are first guided through the fundamentals of neuroanatomy, neurochemistry, and psychiatric genetics. Chapters then illuminate the neurobiological underpinnings of a range of frequently encountered disorders--including ADHD, substance abuse, mood and anxiety disorders, schizophrenia, and learning and cognitive problems--giving particular attention to the impact of psychosocial risk factors on the brain. Also examined are ways that both pharmacological and psychological interventions have been shown to alter brain chemistry as they bring about a reduction in symptoms.
Bringing the latest breakthroughs in neuroscience to the clinician, this text provides resident and practicing psychiatrists with a comprehensive, clinically relevant overview of the brain mechanisms underlying behavior and mental illness. The book presents an integrated perspective on the structures and workings of the brain, the mechanisms governing behaviors such as pleasure, aggression, and intelligence, and the pathophysiology of mental disorders. More than 200 two-color illustrations clarify key concepts. Questions and answers at the end of each chapter facilitate review and board preparation. Readers will also have online access to the complete, fully searchable text and a quiz bank of over 150 questions at www.neuroscienceofclinicalpsychiatry.com.
This book illustrates the current findings of interpersonal neurobiology that inform knowledge building and clinical practice. Contributions cover an impressive range of material including how neurobiology interfaces with clinical work with children, individuals with substance abuse issues, couples and clients with trauma histories. Leading mental health clinician-scholars describe path-breaking explorations at the neurobiological frontiers of 21st century clinical theory and practice. Representing the fields of social work, psychology and psychiatry, these authors creatively apply research findings from the ongoing revolution in social and behaviour neuroscience to a diverse array of clinical issues. Contributions include elaborations of theory (the evolving social brain; new directions in attachment, affect regulation and trauma studies); practice (neurobiologically informed work with children, adults, couples and in the conduct of supervision); and emerging neuroscientific perspectives on broader mental health issues and concerns (substance abuse; psychotropic medications; secondary traumatic stress in clinicians; the neurodynamics of racial prejudice; the dangers of forfeiting humanism to our current romance with the biological). Together, these chapters equip readers with state-of-the-art knowledge of the manner in which new understandings of the brain inform and shape today’s professional efforts to heal the troubled mind. This book was originally published as a special issue of Smith College Studies in Social Work.
In the years following publication of the DSM-5(R), the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text. In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit. Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress. The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5(R), which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.
Current brain research bears on all of the helping professions. This book informs clinical social workers and social work educators about new findings from research on attachment and neurobiology. Topics include brain structure and organization, brain plasticity, normal and abnormal attachment, early trauma, adolescent mothers, parental depression, child abuse and neglect, and assessment and intervention strategies.
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Bridge the gap between the physical foundations of substance abuse and the psychosocial approaches that can treat it!This groundbreaking book offers helping professionals a thorough introduction to the neurobiological aspects of substance abuse. It presents the basic information on the subject, including the various neurobiological theories of addiction, and places them in a psychosocial context. Its clear and straightforward style connects the theoretical information with practical applications. This is an essential resource for substance abuse counselors, researchers, therapists, and social workers. Neurobiology of Addictions offers sound, tested information on substance abuse issues, including: neurobiological theories of addiction integrating drug treatments and therapeutic interventions using neurobiology to discover substance abuse in clients of various ages perspectives from social work, pharmacology, biology, and neuroscience
This book provides an overview of theoretical, empirical, and clinical conceptualizations of mental health following exposure to human rights violations (HRV). There are currently hundreds of millions of individuals affected by war and conflict across the globe, and over 68 million people who are forcibly displaced. The field of refugee and post-conflict mental health is growing exponentially, as researchers investigate the factors that impact on psychological disorders in these populations, and design and evaluate new treatments to reduce psychological distress. This volume will be a substantial contribution to the literature on mental health in refugee and post-conflict populations, as it details the state of the evidence regarding the mental health of war survivors living in areas of former conflict as well as refugees and asylum-seekers.