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Clinical chemistry is a science that requires specific knowledge and teaching. The e-book covers several topics in clinical nephrology. Patients suffering from severe chronic kidney disease may be quasi asymptomatic. This lack of overt symptomatology sugg
Volume 68 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory. - Expertise of international contributors - Latest cutting-edge technologies - Comprehensive in scope
This textbook on renal medicine is the first local book on the subject. The second, revised edition of the book first published in 1991, provides a broad review of kidney diseases with regard to symptoms, investigation and treatment. It deals with a variety of clinical entities such as glomerulonephritis, renal stones, hypertension, urinary infection and renal failure. Chapters on dialysis and transplantation highlighting local incidence and statistics have been included. Also included are current concepts and therapies of kidney diseases and latest statistics on kidney diseases. Written in a clear and concise style, this textbook should serve as a useful and practical guide for medical students and doctors preparing for their higher examinations.
Despite constant significant advances, cardiovascular as well as more general outcomes of hemodialysis treatment remain unsatisfactory. The introduction of innovative 'high retention onset' membranes has led to the development of a new treatment modality called 'expanded hemodialysis' (HDx), which is the focus of this book. This new therapy is likely to benefit end-stage kidney disease patients, thanks to enhanced removal of molecules retained by current dialysis techniques. HDx is simple to set up and application does not require special hardware or specific nursing skills. This book contains emerging evidence and fascinating new hypotheses on HDx. It is highly recommended for all physicians and healthcare professionals who are caring for dialysis patients and are seeking innovation and improved care solutions. It will also be of considerable interest to students and fellows.
Acute kidney injury (AKI) is a common diagnosis in daily clinical practice, occuring in virtually all fields of medicine. Critically ill patients are especially prone to the development of AKI due to frequent haemodynamic instability, multiple risk factors and, diagnostic and/or treatment complications. Severe AKI substantially prolongs the intensive care unit (ICU) length of stay, with increased risk of death. AKI is also a predisposing factor for multiple organ dysfunction syndrome and is usually a part of it. For these and other reasons, critical care nephrology plays an irreplaceable role in treating critically ill patients in ICUs. The current trend in medicine generally not only in critical care nephrology is to gather as much scientific knowledge as possible and in medicine, everything is interrelated. Further, knowledge of pathophysiology and understanding the causes of illness come in an era of increasing polypharmacy and the escalating side effects of drugs. The latter can cause conditions with the same clinical picture as immune system disorders, viruses and bacteria. Another issue is poisonings and drug intoxications, which are a daily issue in ICU settings. In short, the aetiological spectrum of disease has expanded. This book presents the basic principles in critical care nephrology and covers the epidemiology, pathophysiology, the most frequent syndromes, poisonings and conservative or invasive treatment options. The aim is to present an easily understandable overview using relevant scientific research results, along with the authors own practical clinical experience from the University Hospital of Ostrava in the Czech Republic. The authors believe that this textbook will be useful to physicians who have to make rapid diagnoses and decision making in daily ICU practice.
Landmarks in Nephrology points the reader to some of the seminal observations which have led to the practice of nephrology as we know it today.Twenty areas of nephrology are covered by discrete chapters, with the editors selecting the ten most important papers ever published in that field. These range from observational and experimental studies from the 18th century, which laid the groundwork for our current understanding of the kidney, through to recent randomized controlled clinical trials. The papers also reflect the emergence of nephrology as a speciality in the last fifty years, stimulated particularly by the introduction ofrenal biopsy and the development of dialysis and transplantation as effective forms of renal replacement therapy. For each paper, there is a succinct commentary which highlights the importance of the work in its historical context, as well as a recommended reading section to encourage the interestedreader to explore further.It is of course a near-impossible task to choose only two hundred papers from the whole oeuvre of nephrology. However, these chosen few are undoubtedly among the great landmarks of nephrology, reflecting the varying coincidences of brilliance, persistence, and good fortune which are necessary for progress in medical science. Encompassing the breadth, range and depth of the intellectual journey which precedes us in the development of nephrology, they provide a telling illustration of Sir IsaacNewtons words to Robert Hooke in 1675: If I have seen further, it is by standing on the shoulders of giants.
Kidney disease touches nearly 14% of the population. Of the 661,000 Americans at the end stage of chronic kidney disease, 468,000 require dialysis and 193,000 have an effective kidney transplant. Both are miracles and have reshaped an illness once universally fatal into one of expectation and life. (Source: NIDDK) However, Medicare payments for dialysis alone are 34 billion dollars a year; it is among their foremost expenditures. (Source: USRDS). As both a life-saving procedure and a costly enterprise, the management of kidney disease commands the attention of care givers, providers and patients. Our understanding of the nuances of care make a difference, not just in the quality and betterment of the lives of patients, but in reducing the cost burdens we as a society must bear.Within this context, the intent of this book is to anticipate what the practicing nephrologist or internist needs to know when approaching, diagnosing and managing a patient with kidney disease. It is also designed to inspire the reader to seek a deeper understanding of the subject that pertains to the patient being treated.It is also ideal to use as a reference, as it is packed full of knowledge that will be most useful at the point of care. Thus, it is to be kept on the desk or a convenient shelf in a doctor's office, or in the house staff or clinic break room, so that it is easily accessible for everyday use.The book is divided into five sections. The first section, "The Approach to Chronic Kidney Disease", consists of eleven chapters. Each chapter is designed to help the clinician gain perspective in caring for kidney patients, and taken together, will help create the foundation on which to build a well-rounded approach to CKD patients. In the second section, "Major Medical Conditions and Management", an additional eleven chapters each focus on a specific disorder and how it can be best approached. These disorders range from everyday conditions like hypertension and diabetes to those that are rarely seen. The seven chapters of the third section, "Management Principles in CKD", focus on specific conditions and complications that result from an impairment in kidney function.Once a patient has reached the point where renal replacement therapy is necessary, there are several options and modalities that are available. The nine chapters of the next section, "ESRD Replacement Therapy", will discuss modalities and the approaches taken to optimize the patient's quality of life and well-being. The final section, "Innovations and Updates in Kidney Disease", includes two chapters that will give the reader a glimpse of what is on the horizon.
This book is a wide-ranging guide to current and emerging applications of ultrasonography within nephrology that aims to provide readers with a sound understanding of the rationale for the use of ultrasound techniques in various disease settings, for example, complications following renal transplantation, arteriovenous fistulas, renal artery stenosis, nonstenotic renal artery pathology, renal vein pathology, aortic disease, and acute renal failure. Particular emphasis is placed on newer applications, such as those involving elastosonography, contrast-enhanced ultrasonography, and color Doppler imaging. There is no doubt that ultrasound techniques can improve the standard of care in nephrology, from vascular access planning to management of uremic complications. Nevertheless, many nephrologists continue to delegate the performance of ultrasonography to radiologists or other colleagues, which is especially regrettable given the advent of affordable, portable ultrasound scanners. This book will be of value for all clinicians interested in the role of ultrasound techniques in nephrology and will be especially useful for nephrologists seeking to incorporate ultrasonography into their practice.
Clinical Chemistry considers what happens to the body’s chemistry when affected by disease. It provides introductory coverage of the scientific basis for biochemistry tests routinely used in medicine - including tests for the assessment of organ function, diagnosis and monitoring disease activity and therapy efficacy. Each topic area begins with a concise description of the underlying physiological and biochemical principles and then applies them to patient investigation and management. The regular use of case histories helps further emphasise clinical relevance and chapter key points, as well as provide a useful starting point for examination revision. The clear and engaging writing style appreciated by generations of readers has been retained in this ninth edition, while the content has been thoroughly updated throughout. The approach and scope of this trusted text makes it ideal for integrated medical curricula, for medical training and for students and practitioners of clinical and biomedical science. The complementary eBook version, including additional cases and self-assessment material, completes this superb learning package. Updated to incorporate the latest changes in practice – including new tests and the most recent evidence-based guidance – plus a new chapter on clinical chemistry in pediatrics. Figures, tables, boxes, and case studies aid understanding and learning. ‘Light bulb’ sections give practical advice and clarify difficult concepts or potential pitfalls. New ‘Red flag’ boxes highlight the results which should cause immediate concern to clinicians. Updated references to core guidelines reflect latest best practice.