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How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation.Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.
Each year, child protective services receive reports of child abuse and neglect involving six million children, and many more go unreported. The long-term human and fiscal consequences of child abuse and neglect are not relegated to the victims themselves-they also impact their families, future relationships, and society. In 1993, the National Research Council (NRC) issued the report, Under-standing Child Abuse and Neglect, which provided an overview of the research on child abuse and neglect. New Directions in Child Abuse and Neglect Research updates the 1993 report and provides new recommendations to respond to this public health challenge. According to this report, while there has been great progress in child abuse and neglect research, a coordinated, national research infrastructure with high-level federal support needs to be established and implemented immediately. New Directions in Child Abuse and Neglect Research recommends an actionable framework to guide and support future child abuse and neglect research. This report calls for a comprehensive, multidisciplinary approach to child abuse and neglect research that examines factors related to both children and adults across physical, mental, and behavioral health domains-including those in child welfare, economic support, criminal justice, education, and health care systems-and assesses the needs of a variety of subpopulations. It should also clarify the causal pathways related to child abuse and neglect and, more importantly, assess efforts to interrupt these pathways. New Directions in Child Abuse and Neglect Research identifies four areas to look to in developing a coordinated research enterprise: a national strategic plan, a national surveillance system, a new generation of researchers, and changes in the federal and state programmatic and policy response.
Several excellent monographs exist which deal with axons. These, however, focus either on the cellular and molecular biology of axons proper or on network organization of connections, the latter with only an incidental or abstract reference to axons per se. Still relatively neglected, however, is the middle ground of terminations and trajectories of single axons in the mammalian central nervous system. This middle level of connectivity, between networks on the one hand and local, in vitro investigations on the other, is to some extent represented by retrograde tracer studies and labeled neurons, but there have so far been many fewer of the complementary anterograde studies, with total visualization of the axonal arborization. The present volume brings together in one source an interrelated treatment of single axons from the perspective of microcircuitry and as substrates of larger scale organization (tractography). Especially for the former area - axons in microcircuitry - an abundance of published data exists, but these are typically in specialty journals that are not often accessed by the broader community. By highlighting and unifying the span from microcircuitry to tractography, the proposed volume serves as a convenient reference source and in addition inspires further interactions between what currently tend to be separate communities. The volume also redresses the imbalance between in vitro/local connectivity and long-distance connections. Focusing on mammalian systems, Part 1 of this book is devoted to anatomical investigations of connections at the single axon level, drawing on modern techniques and classical methods from the 1990s. A particular emphasis is on broad coverage of cortical and subcortical connections from different species, so that common patterns of divergence, convergence, and collateralization can be easily appreciated. Part 2 addresses mechanisms of axon guidance, as these seem particularly relevant to pathways and branching patterns. Part 3 covers axon dynamics and functional aspects; and Part 4 focuses on tractography, notably including comparisons between histological substrates and imaging.
Spatial neglect is a disorder of space-related behaviour. It is characterized by failure to explore the side of space contralateral to a brain lesion, or to react or respond to stimuli or subjects located on this side. Research on spatial neglect and related disorders has developed rapidly in recent years. These advances have been made as a result of neuropsychological studies of patients with brain damage, behavioural studies of animal models, as well as through functional neurophysiological experiments and functional neuroimaging. The Cognitive and Neural Bases of Spatial Neglect provides an overview of this wide-ranging field of scientific endeavour, providing a cohesive synthesis of the most recent observations and results. As well as being a fascinating clinical phenomenon, the study of spatial neglect helps us to understand normal mechanisms of directing and maintaining spatial attention and is relevant to the contemporary search for the cerebral correlates of conscious experience, voluntary action and the nature of personal identity itself. The book is divided into seven sections covering the anatomical and neurophysiological bases of the disorder, frameworks of neglect, perceptual and motor factors, the relation to attention, the cognitive processes involved, and strategies for rehabilitation. Chapters have been written by a team of the leading international experts in this field. This will be essential reading for neuropsychologists, neurologists, neurophysiologists, cognitive neuroscientists and psychologists.
Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
Unilateral neglect is a fairly common disorder, usually associated with a stroke, which results in a neglect or lack of attention to one side of space usually, but not exclusively, the left. Theoretically, it is one of the most interesting and important areas in neuropsychology; practically, it is one of the greatest therapeutic problems facing therapists and rehabilitationists. This book covers all aspects of the disorder, from an historical survey of research to date, through the nature and anatomical bases of neglect, and on to review contemporary theories on the subject. The final section covers behavioural and physical remediation. A greater understanding of unilateral neglect will have important implications not just for this particular disorder but for the understanding of brain function as a whole.
Spatial Neglect is one of the few areas in Neuropsychology where clinicians, psychologists and animal experimenters have succeeded in adopting a common language. The result of interaction between these three approaches has been some important new advances, which are presented in this volume.Apart from its clinical significance in neuropsychology, Spatial Neglect raises important questions in the field of behavioral neurosciences. In this volume, three aspects are examined: a) normal subjects, where new findings on spatial behavior are described. b) brain-lesioned subjects, where the classical studies on neglect are reconsidered in the light of new findings. c) animals, where new experimental situations allow a deeper understanding of the neural substrate.
Until recently, neuroscientists thought glial cells did little more than hold your brain together. But in the past few years, they've discovered that glial cells are extraordinarily important. In fact, they may hold the key to understanding intelligence, treating psychiatric disorders and brain injuries and perhaps even curing fatal conditions like Alzheimer's, Parkinson's, and Lou Gehrig's Disease. In The Root of Thought, leading neuroscientist Dr. Andrew Koob reveals what we've learned about these remarkable cells, from their unexpected role in information storage to their function as adult stem cells that can keep your brain growing and adapting longer than scientists ever imagined possible. Ranging from fruit flies to Einstein, Koob reveals the surprising correlation between intelligence and the brain's percentage of glial cells - and why these cells' unique wavelike communications may be especially conducive to the fluid information processing human beings depend upon. You'll learn how crucial glial cells grow and develop... why almost all brain tumors are comprised of glial cells and the potential implications for treatment... even the apparent role of glial cells in your every thought and dream!