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Negative Affective States and Cognitive Impairments in Nicotine Dependence is the only book of its kind that addresses nicotine use and abuse in the context of negative reinforcement mechanisms. Written and edited by leading investigators in addiction, affective, genetic, and cognitive research, it provides researchers and advanced students with an overview of the clinical bases of these effects, allowing them to fully understand the various underlying dysfunctions that drive nicotine use in different individuals. In addition, this book examines animal models that researchers have utilized to investigate the biological bases of these dysfunctions. The combination of clinical and preclinical approaches to understanding nicotine dependence makes this book an invaluable resource for researchers and practitioners seeking to develop targeted treatments aimed at ameliorating symptoms of nicotine dependence, as well as identifying premorbid differences in affective or cognitive function. - Provides a unique perspective on nicotine dependence that emphasizes negative reinforcement rather than positive reinforcement - Examines psychiatric comorbidities and alleviation of withdrawal states as motivation for continued tobacco use - Includes both clinical and preclinical perspectives - Includes genetic and multi-neurotransmitter perspectives on nicotine use and withdrawal - Emphasizes heterogeneity of underlying reasons for smoking, the need for multiple animal models to understand this heterogeneity, and the expectation of heterogeneous responses to potential treatments, underscoring the need for personalized therapeutics
This booklet for schools, medical personnel, and parents contains highlights from the 2012 Surgeon General's report on tobacco use among youth and teens (ages 12 through 17) and young adults (ages 18 through 25). The report details the causes and the consequences of tobacco use among youth and young adults by focusing on the social, environmental, advertising, and marketing influences that encourage youth and young adults to initiate and sustain tobacco use. This is the first time tobacco data on young adults as a discrete population have been explored in detail. The report also highlights successful strategies to prevent young people from using tobacco.
The book includes an examination of sources of law important to addiction and its treatment. The foundations for forensic work in professional legal testimony is explored (e.g., legal system, case law precedent, statutes governing addictions, civil and criminal procedures). The science of addiction is featured including the biology of addiction, addiction as a brain disease, responsibility vs. loss of control, development of addictions, and the role of genetics and environment. Drug testing, its uses with forensic populations, what the tests show and do not show, controversies in using tests in the general population also receives extensive treatment. Addiction and mental illness in forensic populations is highlighted for addiction treatment and continuing care. Case studies and landmark cases illustrate the role of alcohol, drug use, and addictions in legal decisions. - Focused primarily on alcohol and drug addictions - Case studies and landmark cases are included to illustrate the role of alcohol/drugs in legal decisions (e.g., the Exxon Valdez case) - Brief overview of legal system and drug courts will be useful to clinicans, lawyers, administrators, and other professionals
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
The primary purpose of this book and its companion volume The Behavioral Genetics of Nicotine and Tobacco is to explore the ways in which recent studies on nicotine and its role in tobacco addiction have opened our eyes to the psychopharmacological properties of this unique and fascinating drug. While The Behavioral Genetics of Nicotine and Tobacco considers the molecular and genetic factors which influence behavioral responses to nicotine and how these may impact on the role of nicotine in tobacco dependence, the present book focuses on the complex neural and psychological mechanisms that mediate nicotine dependence in experimental animal models and their relationship to tobacco addiction in humans. These volumes will provide readers a contemporary overview of current research on nicotine psychopharmacology and its role in tobacco dependence from leaders in this field of researchand will hopefully prove valuable to those who are developing their own research programmes in this important topic.
Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.
Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to distinct neurobiological substrates that could underlie anhedonic phenotypes. Taking an integrative approach that emphasizes cross-species integration and dimensional conceptualization of mental illnesses (e.g., Research Domain Criteria (RDoC)), this book represents the most comprehensive evaluation, synthesis and integration of theories and empirical findings focused on anhedonia. Organized across five parts, the handbook starts with chapters on the history, etiology, and assessments of anhedonia (Part I), followed by a section on the role of anhedonia in psychiatric and neurological disorders (Part II). Using the RDoC Matrix as a guide, Part III presents chapters synthetizing preclinical and clinical findings on different reward processing subdomains (e.g., reward responsiveness, reward valuation, reward learning). Part IV is focused on selected special topics, including historical and current perspectives on the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, the use of computational modeling to “dissect” anhedonia and improve its understanding, and links between anhedonia and suicide. Finally, Part V includes chapters on pharmacological, psychological and neurostimulation treatments for anhedonia.
Based on the study of neuroscientific developments and innovations, examined from different angles, this Handbook provides a comprehensive overview of the international neuroethical debate, and offers unprecedented insights into the impact of neuroscientific research, diagnosis, and therapy. Neuroethics – as a multi-disciplinary and inter-disciplinary endeavor – examines the implications of the neurosciences for human beings in general and for their self-understanding and their social interactions in particular. The range of approaches adopted in neuroethics and thus in this handbook includes but is not limited to historical, anthropological, ethical, philosophical, theological, sociological and legal approaches. The Handbook deals with a plethora of topics, divided into in three parts: the first part contains discussions of theories of neuroethics and how neuroscience impacts on our understanding of personal identity, free will, and other philosophical concepts. The second part is dedicated to issues involved in current and future clinical applications of neurosciences, such as brain stimulation, brain imaging, prosthetics, addiction, and psychiatric ethics. The final part deals with neuroethics and society and includes chapters on neurolaw, neurotheology, neuromarketing, and enhancement.
Emotions are complex and multifaceted phenomena. Although they have been examined from a variety of perspectives, the study of the interaction between cognition and emotion has always occupied a unique position within emotion research. Many philosophers and psychologists have been fascinated by the relationship between thinking and feeling. During the past 30 years, research on the relationship between cognition and emotion has boomed and so many studies on this topic have been published that it is difficult to keep track of the evidence. This book fulfils the need for a review of the existing evidence on particular aspects of the interplay between cognition and emotion. The book assembles a collection of state-of-the-art reviews of the most important topics in cognition and emotion research: emotion theories, feeling and thinking, the perception of emotion, the expression of emotion, emotion regulation, emotion and memory, and emotion and attention. By bringing these reviews together, this book presents a unique overview of the knowledge that has been generated in the past decades about the many and complex ways in which cognition and emotion interact. As such, it provides a useful tool for both students and researchers alike, in the fields of social, clinical and cognitive psychology.
Practitioners helping smokers to quit can be more effective by learning key therapeutic techniques aimed at increasing any smoker’s chances of success. Cognitive-Behavioral Therapy for Smoking Cessation is a valuable guidebook to an empirically based CBT approach to smoking cessation that has been shown to be effective with or without the use of medications. This approach emphasizes techniques for enhancing the smoker’s motivation and confidence to quit, and teaching the smoker steps for preparing to quit, coping with the difficulties that emerge after quitting, and transitioning to become a long term nonsmoker. Cognitive-Behavioral Therapy for Smoking Cessation offers the fundamental counseling strategies and interventions that have been established, researched, and refined over the past decade. This program outlines essential components that should be included in the treatment of any smoker, as well as steps to take when faced with smokers likely to have particular difficulty quitting. Unique to this volume is the inclusion of a specifically tailored CBT model designed to address weight gain concerns in the smoker. Perkins, Conklin, and Levine are leading researchers on effective smoking cessation intervention for those concerned about the potential gain in weight that accompanies quitting, and offer a flexible approach that allows the practitioner to tailor interventions to each individual. An invaluable addition to any health professional’s repertoire, the treatment model presented in this book provides practitioners with the tools necessary to help their clients to quit smoking.