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The interaction between new forms of biological life and new forms of social life in modern democracies. The molecular life sciences are making visible what was once invisible. Yet the more we learn about our own biology, the less we are able to fit this knowledge into an integrated whole. Life is divided into new sub-units and reassembled into new forms: from genes to clones, from embryonic stages to the building-blocks of synthetic biology. Extracted from their scientific and social contexts, these new entities become not only visible but indeed “naked”: ready to assume an essential status of their own and take on multiple values and meanings as they pass from labs to courts, from patent offices to parliaments and back. In Naked Genes, leading science scholar Helga Nowotny and molecular biologist Giuseppe Testa examine the interaction between these dramatic advances in the life sciences and equally dramatic political reconfigurations of our societies. Considering topics ranging from assisted reproduction and personalized medicine to genetic sports doping, they reveal both surprising continuities and radical discontinuities between the latest advances in the life sciences and long-standing human traditions.
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.
Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Memetics is the name commonly given to the study of memes - a term originally coined by Richard Dawkins to describe small inherited elements of human culture. Memes are the cultural equivalent of DNA genes - and memetics is the cultural equivalent of genetics. Memes have become ubiquitous in the modern world - but there has been relatively little proper scientific study of how they arise, spread and change - apparently due to turf wars within the social sciences and misguided resistance to Darwinian explanations being applied to human behaviour. However, with the modern explosion of internet memes, I think this is bound to change. With memes penetrating into every mass media channel, and with major companies riding on their coat tails for marketing purposes, social scientists will surely not be able to keep the subject at arm's length for much longer. This will be good - because an understanding of memes is important. Memes are important for marketing and advertising. They are important for defending against marketing and advertising. They are important for understanding and managing your own mind. They are important for understanding science, politics, religion, causes, propaganda and popular culture. Memetics is important for understanding the origin and evolution of modern humans. It provides insight into the rise of farming, science, industry, technology and machines. It is important for understanding the future of technological change and human evolution. This book covers the basic concepts of memetics, giving an overview of its history, development, applications and the controversy that has been associated with it.
Harnessing the Power of Viruses explores the application of scientific knowledge about viruses and their lives to solve practical challenges and further advance molecular sciences, medicine and agriculture. The book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are discussed. It steers away from traditional views of viruses and technology, focusing instead on viral molecules and molecular processes that enable science to better understand life and offer means for addressing complex biological phenomena that positively influence everyday life. The book is written at an intermediate level and is accessible to novices who are willing to acquire a basic level of understanding of key principles in molecular biology, but is also ideal for advanced readers interested in expanding their biological knowledge to include practical applications of molecular tools derived from viruses. - Explores virus-based tools and approaches in DNA manipulation, protein expression and characterization and virus-host interactions - Provides a dedicated focus on viral molecules and molecular processes that enable science to better understand life and address complex biological phenomena - Includes an overview of modern technologies in biology that were developed using viral components/elements and knowledge about viral processes
Hermann Joseph Muller (1890-1967) was a member of the early genetics group at Columbia University that developed the chromosome theory of inheritance. T. H. Morgan received the Nobel Prize in Medicine and Physiology for this work in 1934, and Muller, his student, received the Nobel Prize in 1946 for his discovery of radiation-induced mutation. The Modern Concept of Nature: Essays on Theoretical Biology by H. J. Muller, deals with Muller's major contributions to the theory of the gene, the induction of mutations, the principles of genetic load, and the neo-Darwinian theory of evolution. These essays contributed to the modern outlook of biology, and they are important to the historian and the biologist who wish to trace the evolution of scientific concepts or to read, first hand, the papers which laid the basis for the major portion of our genetic knowledge. Muller's writings extended beyond contributions to technical journals. He was an active critic of social abuse of science; he advocated eugenic programs based on free choice; and he played a major role in the reform of high school biology. Muller's social views were published in magazines and journals which are accessible to scholars more than to the lay reader or student. They have been collected in a companion volume, Man's Future Birthright: Essays in Science and Humanity by H. J. Muller, also published by State University of New York Press, to show how extensively he thought our lives are affected by radiation, evolution, modern medicine, and gene theory. He attempted to alert humanity to the dangers of neglect and abuse of their genetic heritage. He also used humanistic values to urge mankind to improve itself, to foster cooperativeness, to increase health and intelligence, and to adopt an evolutionary outlook. The relation of science to values is often neglected because of the inaccessibility of the written contributions of important scientists. To read Muller's major essays in these two areas is an important way to evaluate a scientist's career, his maturation of ideas, and his developing application of science to society.
Mankind is defined not as the animals that have souls, but as the animals that can INVENT ideas, and then TALK about them, (inventiveness and language). Signs of these two momentous abilities are documented to have SUDDENLY started only about 30,000 years ago. The G-SAT Theory, detailed in this book, offers a SCIENTIFIC frame, for a master-planned, purely physical process, that initiated Mankind. DNA is NOT synonymous with 'GENES'. DNA is the ink and paper on which the encoded messages of the genes get recorded. Every year, we come closer to deciphering how these messages work. With this rapidly progressing scientific discipline, we are getting closer, by the day, to scientifically proving my pre-determined-encoded theory.