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In recent years, the near-infrared spectroscopy (NIRS) technique has revolutionised the way in which muscle oxidative metabolism is non-invasively measured during the natural execution of movements. Therefore, the NIRS technique has been increasingly utilised in research and clinical laboratories around the world to investigate the dynamic changes in muscle oxygenation during exercise. The book presents a comprehensive understanding of the NIRS technique, research applications, and advanced analysis methods used to measure muscle oxygenation during voluntary and electrically evoked exercise. The book should be especially useful to exercise physiologists and clinicians, or anyone else who may be considering utilizing NIRS to better understand the physiology of skeletal muscle during exercise.
From the 39th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Washington, DC, USA in July 2011, this volume covers aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence. Oxygen Transport to Tissue XXXIV includes contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians.
117 million people in the United States today suffers from a chronic disease associated with an insufficient oxygen delivery to muscle. Clinicians need a fast, easy, non-invasive way to measure oxygen saturation. Near-Infrared Spectroscopy (NIRS) is a non-invasive procedure whose signal reflects tissue oxygenation. We hypothesized however that near-infrared spectroscopy (NIRS) measures of hemoglobin and/or myoglobin 02 saturation do not reflect the venous oxygen saturation because of the Hb and Mb contributions to the NIRS signal. A computational model previously developed to describe the dynamic and spatial changes of O2 concentration in blood and tissue domains of contracting skeletal muscle was modified to quantify Hb and Mb contributions to the NIRS signal. In addition, the effect of blood flow kinetics in a normal and disease state with corresponding NIRS signals were also analyzed.
Near-infrared spectroscopy (NIRS) is a very useful technique for noninvasive measurement of tissue oxygenation Among various methods of NIRS, continuous wave near-infrared spectroscopy (CW-NIRS) is especially suitable for real-time measurement and for practical use. CW-NIRS has recently been applied to in vivo reflectance imaging of muscle oxygenation and brain activity. However, conventional mapping systems do not have a sufficient mapping area at present. Moreover; they do not enable quantitative measurement of tissue oxygenation because conventional NIRS is based on the inappropriate assumption that tissue is homogeneous. In this study, we developed a 200- channel mapping system that enables measurement of changes in oxygenation and blood volume and that covers a wider area (30 cm x 20 cm) than do conventional systems. The spatial resolution (source-detector separation) of this system is 15 mm. As for the effects of tissue inhomogeneity on muscle oxygenation measurement, subcutaneous adipose tissue greatly reduces measurement sensitivity. Therefore, we also used a correction method for the influence of the subcutaneous fat layer so that we could obtain quantitative changes in concentrations of oxy- and deoxy-hemoglobin. We conducted exercise tests and measured the changes in hemoglobin concentration in the thigh using the new system. The working muscles in the exercises could be imaged, and the heterogeneity of the muscles was shown. These results demonstrated the new 2O0-channel mapping system enables observation of the distribution of muscle metabolism and localization of muscle function.
This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.
The purpose of this dissertation series was to examine oxygen uptake kinetics in skeletal muscle by evaluating responses of local muscle deoxygenation during incremental exercise in healthy individuals using near-infrared spectroscopy (NIRS). Metabolic activity in skeletal muscle, as part of the integrative responses of the cardiovascular, respiratory and neuromuscular systems, are major determinants of an individual's physical capacity and function. The workings of these systems, called whole-body metabolism, affect the capability of an individual to engage in activities of daily living, to exercise, and participate in athletic performance. Thus, they have a strong impact on health as engagement in physical activity is well known to be effective in improving cardiorespiratory fitness and reducing the risks of chronic disease. At this time, the in vivo relationships between whole-body metabolism and local muscle metabolic activity are not well understood, but with the availability of NIRS technology this is possible.
Regular physical activity can help people improve both physical and mental health. As people pay more attention on their health, fitness has become a popular activity. For individuals who have specific training goals, such as losing fat, gaining weight, and preparing to participate in competitions, it is important to avoid injury during exercise and improve the efficiency of training. Physiological monitoring during exercise, such as heart rate, blood lactate, oxygen uptake, and tissue oxygenation, is helpful for improve the effectiveness and safety of training. Many researchers are devoting their efforts to propose methodology and invent instruments of measuring these metrics. It is well known that heart rate is a commonly used measurement indicator, which can be measured on many fitness equipment and wearable devices. However, heart rate is a global parameter of the trainer's body and cannot represent the training intensity of a specific muscle. Because the muscles are directly affected by the exercise, it is necessary to measure the metrics of muscles to determine whether a specific muscle can tolerate the exercise load or not. If the muscles are overworked, there is a high probability of injury, which must be avoided. Hence, it is imperative to measure local muscles. Muscle oxygen saturation (SmO2) is an indicator of the altering between oxygen delivery and consumption in the muscles. The more intense the exercise, the more oxygen is consumed by the muscles. So SmO2 is a good indicator to assess how fatigued a specific muscle is. In sports science, it is usually measured non-invasively by near-infrared spectroscopy (NIRS). Many instruments were developed by researchers previously based on different NIRS techniques and algorithms. In this thesis, a methodology of measuring absolue value of SmO2 was proposed for a wearable measurement device with one source and two detectors using 5-wavelength NIRS. The algorithm of fitting the light attenuation to the Taylor expansion model by bound-constrained non-linear least squares fitting was evaluated with simulated tissues. For in vivo measurement, an orthogonalization technique was introduced to reduce the effect of the absorption and scattering of overlying tissues. With comparison and analysis, the measuring SmO2 values of two designed running procedures were reasonable. During exercise, the trainer may not always wear the device correctly and the device may move or fall off. And some of the individuals may not exercise as the designed training procedures. So the measured data will be unreliable in these cases. In order to remind users to wear the device properly and to train as the designed procedures, a fault diagnostic method was proposed by machine learning approach in this thesis. With labelling data by its reliability and splitting data into different training status, a support vector machines (SVM) model with Gaussian radial basis function kernel was trained. According to two evaluation curves, ROC curve and cross-validation learning curve, the SVM classifiers in both training states can achieve an accuracy of over 97%. These trained models can be applied as a fault diagnostic for the measurement device. There is no screen on the device, so the results need to be displayed on a computer or mobile phone. In this thesis, an application that integrated the SmO2 calculation and fault diagnostic was developed in Matlab App Designer. With this application, after three clicks by users, the SmO2 curve during training and the absolute values could be displayed in the interface. Since the device didn't have the feature of real-time wireless transmission, a simulation of real-time mode was done to show the possibility of real-time measurement in the future.
Photoplethysmography: Technology, Signal Analysis, and Applications is the first comprehensive volume on the theory, principles, and technology (sensors and electronics) of photoplethysmography (PPG). It provides a detailed description of the current state-of-the-art technologies/optical components enabling the extreme miniaturization of such sensors, as well as comprehensive coverage of PPG signal analysis techniques including machine learning and artificial intelligence. The book also outlines the huge range of PPG applications in healthcare, with a strong focus on the contribution of PPG in wearable sensors and PPG for cardiovascular assessment. - Presents the underlying principles and technology surrounding PPG - Includes applications for healthcare and wellbeing - Focuses on PPG in wearable sensors and devices - Presents advanced signal analysis techniques - Includes cutting-edge research, applications and future directions