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This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.
This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.
This dense study conducted by Prof. Dr. Mike K.S. Chan and Prof. Dr. Michelle B.F. Wong, with the support of a professional team of researchers, highlights how important is to delve deeper into the study of the thymus gland which plays a crucial role in immune system health. As we read in the forewords the topics presented are the results of a collaboration between experts coming from various fields such as immunology, gerontology, regenerative medicine, and clinical practice. This comprehensive book can strengthen the communication and collaboration among these disciplines, fostering a more holistic approach to addressing age-related health challenges. Bioregenerative medicine in general, and Thymic regeneration therapies are an important part of the daily medical practice. THYMUS THERAPY represents a pivotal study and another scientific milestone that puts once again Prof. Chan and his Team at the forefront worldwide. Prof. Dato Sri Dr. Mike K.S. Chan, is a pioneer of Cellular, Organo and Cell Membrane Therapies in Europe and Asia since the early 1980’s. He founded one of the world’s largest research groups of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, bio-regenerative medicine, and stemcell therapies. Author & co-author of numerous books and articles in the fields of cell therapy, immunology, bio-regenerative sciences, nutrition, and innovator of cellular based nutraceuticals & cosmeceuticals, Prof. Mike Chan is also the founder of European Wellness Biomedical Group—an International chain of research and treatment facilities (European Wellness Centers & Retreats) involved in anti-aging, longevity and education (European Wellness Academy). He chairs and also sits on board on numerous prominent antiaging and cell therapy associations of the world. Prof. Dato Sri Dr. Michelle Wong Bi Fah, ND, PhD is a scientist, researcher and educator actively involved in research and development (R&D) work on stem cells focusing on Fetal Precursor Stem-Cell Therapy. She is the Co-Founder/Senior Technical Advisor and Researcher in FCTI Inc., specialising in Stem cell Research and Bio-Regenerative Medicine for more than three decades. A prominent speaker, Michelle Wong presents at educational programs and global conferences on stem cells, cell therapy and biological medicine for physicians and healthcare practitioners worldwide.
Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. - Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others - Includes full color figures, photos, tables, graphs and radioimaging - Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors - Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment
Written by NPs and PAs who have a wealth of experience in the care of older adults across all practice settings, Gerontology and Geriatrics for NPs and PAs takes an evidence-based approach to both gerontology and geriatrics, incorporating the latest national and international guidelines and standards of care. This first-of-its-kind text takes an interprofessional, teamwork-based approach that reflects Interprofessional Education Collaborative (IPEC) core competencies, as well as the unique perspectives that NPs and PAs each bring to the collaborative care of older adults. - Covers both primary care and acute care of older adults and fully addresses both graduate-level and practitioner core competencies necessary for optimal care of older adults. - Places a strong emphasis on wellness (including nutrition and the Healthy People 2020 targets), normal aging, common syndromes of aging, disease management, patient safety (particularly in acute care settings), and a patient-centered care approach. - Features vibrant, full-color illustrations, a full-color design for ease of navigation, and graduate-level learning features that include Key Points at the end of each chapter for quick reference and exam preparation. - Addresses a wide range of topics specifically focused on the common medical problems of older adults, with chapters logically organized for efficient study and quick clinical reference. Evolve Instructor site with an image collection and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.
Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. - Covers the role of mTOR by internationally recognized expert contributors in the field. - Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. - Includes analysis of the role of mTOR and in both health and disease. - Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.
Demystifying the science behind new cancer treatments A clear and accessible guide written in everyday language for nurses and other healthcare professionals A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy helps readers understand the science behind many of the newer drug treatments for cancer. Assuming only a basic familiarity with cell biology, this easy-to-digest guide describes how our increased understanding of cancer has been translated into the creation of new cancer treatments with a wide range of targets. Gifted communicator and educator Dr. Elaine Vickers helps you understand the mechanisms of a wide range of individual targeted therapies and immunotherapies — enabling you to communicate effectively with your colleagues and patients. Concise chapters explain how new cancer drugs and immunotherapies work, discuss their benefits, identify their limitations, and more. Now in its second edition, this popular handbook is fully revised to reflect the latest developments in targeted drug therapies and immunotherapies. Entirely new chapters on advancements in various immunotherapies are accompanied by more than 100 new and updated color illustrations. Provides an up-to-date overview of relevant treatment targets for all major cancer types, including hematological cancers Describes cancer biology and the relationship between cancer and the immune system Offers valuable insights into cell communication pathways as a common target Covers small molecule drugs, antibody-based treatments, and cellular therapies, including novel immunotherapies A Beginner’s Guide to Targeted Cancer Treatments and Cancer Immunotherapy is a must-have resource for trainees, practicing nurses, and other healthcare professionals involved in the care of cancer patients, as well as non-specialists who encounter cancer data or cancer terminology in their field.
The Chemotherapy Source Book, Fourth Edition pulls together all the current information on the chemotherapeutic management of cancer patients, including choice of chemotherapeutic agents, use of combinations, and toxicity of individual drugs. Organized by disease site, the book brings together pharmacologic and patient management information in one source that clinicians can consult for any question encountered in the delivery of chemotherapy. This updated Fourth Edition includes new drugs as well as new indications for older drugs. Content has been streamlined to provide essential information more quickly for the busy practitioner. Plus, this edition is softcover for greater portability and convenience.
The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.
Cancer research is now an interdisciplinary effort requiring a basic knowledge of commonly used terms, facts, issues, and concepts. This interdisciplinary book meets this need, providing an authoritative overview to the field. It presents many of the molecules and mechanisms generally important in human cancers and examines a broad, but exemplary, selection of cancers. In addition, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. This book summarizes the state, pitfalls, and potential of these efforts.