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This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.
In the current resurgence of interest in Heidegger, an important aspect of his thought has been neglected--namely, his long-standing interest in Asian philosophy. Heidegger and Asian Thought is the first book devoted to exploring this fascinating topic. It brings together essays twelve scholars from India, China, Japan, Germany, and the United States, most of which were written especially for this volume. The essays discuss Heidegger`s thinking in relation to Vedanta, Taoism, Zen, and Tibetan Buddhist philosophy. Heidegger`s acquaintance with Asian thought--beginning from his familiarity with the Chuang-tzu as early as 1930--is fully documented, including an account of his work on a partial translation of the Tao Te` Ching into German. This book will be of interest not only to Heidegger scholars but also to students of Asian and comparative philosophy and religion.
The common cold is unlike any other human disease because of two f- tors: firstly, it is arguably the most common human disease and, secondly, it is one of the most complex diseases because of the number of viruses that cause the familiar syndrome of sneezing, sore throat, runny nose and nasal congestion. These two factors have made a ‘cure’ for the common cold one of the most difficult scientific and clinical endeavours (a topic often d- cussed in the popular media, where comparisons are made with the ease of putting a man on the moon). The present book brings together a wide range of experts from epidemiologists to virologists and pharmacologists to look at recent advances in our knowledge of the common cold. In some respects the book is unique, as it focuses on the common cold, a syndrome so familiar to the layperson but one that receives little attention from the scientist and clinician. The common cold can be viewed from many different aspects as illustrated in Figure 1. The core knowledge for understanding the common cold must first come from virology and this is discussed in several chapters of the book. There have been major advances in this field because of the use of new methods of detecting viruses such as polymerase chain reaction techniques that have greatly aided our understanding of the epidemiology of viruses associated with common cold.