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It has been over 40 years since Congress and the President have considered significant reforms to the IRS. With this report, once again there is an opportunity to overhaul the IRS and transform it into an efficient, modern, and responsive agency. Presents an integrated approach to changes geared toward making the IRS more user friendly by addressing: congressional oversight, executive branch governance, IRS management and budget; workforce and culture; IRS strategic objectives: customer service, compliance, and efficiency gains; modernization; electronic filing; tax law simplification; taxpayer rights; and financial accountability.
Medical X-rays, including fluoroscopy and CT scans, are a major cause of both cancer and coronary heart disease, according to this new study. This reader-friendly work uses no complex statistical operations. It shows each step between raw data and conclusions, and defines basic terms and concepts. Startling conclusions are supported by detailed reviews of medical studies from the 1940s through the 1990s. The author recommends X-ray procedures at much lower dosage levels. Includes a booklet summarizing conclusions of the study. The author is a professor of molecular and cell biology at the University of California-Berkeley, and has investigated the effects of medical X- rays since the 1960s. Paper edition (unseen), $27. Annotation copyrighted by Book News, Inc., Portland, OR
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.