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A modern retelling of Hamlet, except with a few twists. It's seventies Vegas. Amid the glitz, neon lights, poker players, and flood of cash, Jack Romano, a well-respected self-made casino owner and patriarch, has died. His only son, Nick, arrives home for the funeral and discovers that the death may not have been so accidental. Now he must decide what to do about Claudio, an ambitious, seasoned mobster who is also his dad's so-called business partner. Complications arise as Nick finds himself falling in love with Rosalie, the daughter of one of Claudio's crew. Nick must not only save his family's casino business, but also his dad's hoard of silver, amassed over decades, and stashed in the casino's basement vaults. "The only thing missing are the cement shoes. Malanaphy's tumultuous and thrilling ride through the wise-guy back rooms of not-so-old Las Vegas is a sometimes funny, sometimes not, but always captivating whodunnit that'll keep you turning the pages. The Prince of Las Vegas has it all: Romance, mystery and a fresh take on a Cosa Nostra-esque underworld where behind every poker table there's a mobster looking to grab the great, late Jack Romano's loot. If you can't read this well-honed mobster thriller without cheering on the good guys and boo-hissing the bad ones, well ... fuhgeddaboudit!" - Andy Scontras, author of When You Are Strange "A well written, nostalgic and fun, Vegas crime thriller. Malanaphy's novel does not disappoint!" - Gary Braver, author of Tunnel Vision "Would make a great Scorsese or Tarantino movie." - Douglas Corleone, author of Good As Gone.
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Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.
This volume comprehensively reviews oncology in the precision medicine era of personalized care, latest developments in the field, and indications and clinical trials for the treatment of cancer with targeted therapies, immunotherapy, and epigenetic modulators. It thoroughly addresses concerns of various types of cancers including cancers of the head and neck, lung, colon, esophagus, bladder, pancreas, and breast; melanoma; multiple myeloma; hepatocellular carcinoma; renal cell carcinoma; and sarcomas. It is organized and written in a format that is easy to follow for both clinicians and non-clinical scientists interested in personalized medicine. Chapters cover the identification of the clinical problem and summary of recent findings, tumor biology and heterogeneity, genomics, examples of simple and complex cases, biological pathways, future clinical trials, and financial considerations. Oncology in the Precision Medicine Era: Value-Based Medicine will serve as a useful resource for medical oncologists and healthcare providers tailoring medicine to the needs of the individual patient, from prevention and diagnosis to treatment and follow up.