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Bladder cancer is a common cancer of the urinary tract. It is the fourth leading cause of cancer-related death among men and the seventh among women. Clinical management of bladder cancer is challenging because of the heterogeneity among bladder tumors with respect to invasion and metastasis, frequent occurrence of new tumors in the bladder among patients treated with bladder preservation treatments and poor prognosis of patients with tumors that invade the bladder muscle and beyond. Due to these factors it has been said that the cost per patient of bladder cancer, from diagnosis to death is the highest of all cancers. In addition to it being a significant health problem, bladder cancer is an interesting cancer to study in many ways than one. For example, Environmental factors such as cigarette smoking and other carcinogens play a major role in the development of transitional carcinoma of the bladder, whereas, schitosomasis, a protozoan infection results in squamous cell carcinoma of the bladder. Different molecular pathways with distinct molecular signatures appear to be involved in the development of low-grade versus high-grade bladder tumors. Currently being monitored by an invasive endoscopic procedure, cystectomy, with urine cytology as an adjunct, bladder cancer is at the forefront of developing cancer biomarkers for non-invasive detection. Due to the differences in the invasive and metastatic potential of bladder tumors, treatment options differ depending upon tumor grade and stage. New advances are being made in treatment options to improve the outcome and quality of life for patients with bladder cancer. Similarly, new molecular nomograms are being discovered to predict treatment outcome so that individualized treatment options can be offered to patients.
In 1994, more than 20 years after the military coup of 1973, I returned to Chile to speak with the arpilleristas. While the Chileans were electing the second president of a democratic regime (Eduardo Frei), I taped the testimonies of eight women whom I had not been able to forget during my years of exile in the United States. I recorded their stories so the pain and suffering of so many human beings would not be totally in vain and so that, upon reading their testimonies, we might learn the immeasurable worth of human rights and teach future generations to defend them throughout the world. --Emma Sepulveda
Biography of the Nevada writer Robert Laxalt that focuses on his writing career from journalist to acclaimed author, founder of the University of Nevada Press, and educator.
It’s amateur hour at the White House. So says New York Times bestselling author Edward Klein in his new political exposé The Amateur. Tapping into the public’s growing sentiment that President Obama is in over his head, The Amateur argues that Obama’s toxic combination of incompetence and arrogance have run our nation and his presidency off the rails. “Obama was both completely inexperienced and ideologically far to the left of Americans when he entered the White House,” says Klein. “And he was so arrogant that he didn’t even know what he didn’t know.” Klein, who is known for getting the inside scoop on everyone from the Kennedys to the Clintons, reveals never-before-published details about the Obama administration’s political inner workings and about Barack and Michelle’s personal lives, including: The inordinate influence Michelle wields over Barack and her feud with a high-profile celebrity The real reason Rahm Emmanuel left the White House (it wasn’t for family reasons) Why Valerie Jarrett’s role is closer to that of Rasputin than impartial senior advisor Obama’s problems with American Jews How Obama has purposefully forgotten and ignored those that put him in power, including the Kennedys, and the Jewish and African American communities in Chicago From Obama’s conceited and detached demeanor, to his detrimental reliance on Michelle Obama and Valerie Jarrett’s advice, to the Obamas' extravagant and out-of-touch lifestyle, The Amateur reveals a president whose blatant ignorance and incompetence is sabotaging himself, his presidency, and America.