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Presents recent research efforts in the genetic basis of pattern formation and morphogenesis, especially the expression of adhesion molecules. Reviews our understanding of the structure, function, and genetic control of the three families of molecules involved in adhesion: cell adhesion molecules (CAMs), substrate adhesion molecules (SAMs), and cell junctional molecules (CJMs). Covers the biology and chemistry of CAMs, structure and interaction of SAMs, components of junctional complexes, function in histogenesis and disease, and morphology and development.
Selectionism and the Brain addresses a number of important theoretical issues in light of recent empirical data from neuropsychological studies. Edited by two researchers at The Neurosciences Institute, this volume features contributions from such well-known neuroscientists as W. Singer, L.R. Squire, A. Georgopoulos, and O. Sacks. Selectionism and the Brain evaluates selectionist approaches to brain function, including Gerald Edelmans revolutionary theoryof neural Darwinism, and explores how these approaches change the way we look at neurons, neuronal systems, and the brain.
The idea of form is one of the most fundamental concepts underlying all of the sciences. Our visual system is so well developed that we are able to effortlessly classify and compare visual images. What is not so well developed has been our ability to measure this visual information. This book examines a number of recent approaches currently in use to numerically characterize the biological form. It presents a unique overview of these methods, starting with a review of measurement set in a historical framework. The book will be of interest to graduate students in addition to a wide range of researchers, including those in the specialized fields of human biology, growth and development, orthodontics, botany, biology, ecology, zoology, as well as dentistry and medicine.
A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology. This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury. Key Features * Easy to find, up-to-date reference information * Graphic and photographic plates * Current hot topics and anticipated changes in toxicologic pathology * Standardized chapter format * Topics that are addressed in both a broad and deep manner, resulting in a stand alone text * Added coverage of important environmental toxicants * Chapters authored by internationally recognized experts and peer-reviewed
This book focuses on the role of gangliosides in three areas of medicine in which rapid progress has been made in the last decade: cancer, peripheral neuropathies and Alzheimer's disease. The volume further reflects progress in the pathogenesis of peripheral neuropathies, and the controversial role of gangliosides, also in therapeutic administration. There is a section on the role of gangliosides in neuronal differentiation and development and their receptor functions and cell surface activities. This excellent addition to the renowned Progress in Brain Research series also contains an invaluable plenary lecture on molecular basis of cell adhesion by Nobel prizewinner Gerald Edelman.

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Library of Congress. Office for Subject Cataloging Policy

Published: 1990

Total Pages: 1548


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