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A valuable, new source, Molecular Medical Parasitology is the only text of its kind -- one that applies broad concepts and current scientific advances from both molecular biology and biochemistry to the study of parasitic organisms. An internationally renowned team of scientists and physicians places parasites in their broad biological contexts while still emphasizing the specifics that differentiate these organisms. Not only will researchers and faculty in parasitology find this an indispensable guide, physicians will benefit from the thorough coverage molecular biology and biochemistry's current influences on treatment and management of parasitic diseases. Features the most up-to-date scientific methods behind the medical management of parasitic diseases Applies the most current synthesis of molecular biology and biochemistry to parasitic organisms Contains many informative figures and clear illustrations
In the past years, genome projects for numerous human parasites have been completed and now allow first in depth comparisons and evolutionary conclusions. The genomes of parasites reflect the coevolution with their host, metabolic capacities depending on their respective habitat in the host. Gut parasites usually have an anaerobic metabolism, while blood parasites have an aerobic metabolism, intracellular parasites escape the immune system, while extracellular parasites evade the immune system, usually by antigenic variation. Comprehensive genome data now being available allow us to address profound scientific questions, such as which traits enable the parasite to survive in the human host, which to cause disease and which can be used as drug targets. This book intends to give an overview of the state of knowledge on “the molecules” of protozoan parasites – on their genomes, proteomes, glycomes and lipidomes.
Enzymes; 8.
Veterinary Clinical Parasitology, Eighth Edition, prepared under the auspices of the American Association of Veterinary Parasitologists (AAVP), emphasizes the morphologic identification of both internal and external parasites of domestic animals. Focusing on the tests and information most relevant to daily practice, the book describes accurate, cost-effective techniques for diagnosing parasitic infections in animals. Including clear, easy-to-find information on the distribution, life cycle, and importance of each parasite, Veterinary Clinical Parasitology offers more than 450 images to aid with diagnosis. The Eighth Edition includes a new chapter on immunologic and molecular diagnosis, increased coverage of ticks and new sections on identification of microfilariae and larvae in diagnostic samples. The new edition also features expanded information on quantitative egg counts, detection of anthelmintic resistance and identification of ruminant strongylid larvae. Additional improvements include many new images throughout the book, revised taxonomic information, a new layout featuring tabs by section to improve user-friendliness, and a companion website offering the images from the book in PowerPoint at www.wiley.com/go/zajac. Veterinary Clinical Parasitology is a highly practical benchside reference invaluable to clinicians, technicians, and students.
Experts present methods and protocols essential for understanding parasites at the molecular level. The protocols cover culturing techniques for the major experimental organisms, methods for isolating and processing nucleic acids and proteins, PCR-based protocols for parasite identification, gene isolation and mutation, antibody-based procedures, chromosome and epitope mapping, flow cytometry, RNA sequencing, and parasite transformation.
The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the way for the treatment and prevention of the diseases they cause. Biochemistry and Molecular Biology of Parasites presents an up-to-date account of this modern scientific discipline in a manner that allows and encourages the reader to place the biochemistry and molecular biology of these organisms in their biological context. The chapters are cross-referenced and grouped in an arrangement that provides a fully integrated whole, and permits the reader to create a composite of the biochemical function of these organisms. Individual chapter includes those devoted to metabolism, in both aerobic and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are discussed not only from the point of view of their cellular biochemistry and metabolism, but also with respect to both their integrated functions such as neurochemistry, structure and functions of surfaces, and reproduction. Written by expert investigators, this book will be of interest to all experienced researchers, graduate students, and to the newcomer eager to become familiar with the biochemistry and molecular biology of parasites.
It is estimated that more than half of the human population, plus a much greater number of domestic and wild animals suffer from parasitic infections. In addition to their relevance in human and animal health, parasites have become the object of extensive studies by cellular and molecular biologists. The present volume of Essays in Biochemistry provides an overview of recent advances in the biochemistry and molecular biology of the most relevant unicellular parasites. The most recent advances in the study of these human parasites (Trypanosoma, Leishmania, Plasmodium, Toxoplasma, Trichomonas, Giardia and Entamoeba) will be discussed after a short introduction about the general progress in the field.
Diagnostic Medical Parasitology covers all aspects of human medical parasitology and provides detailed, comprehensive, relevant diagnostic methods in one volume. The new edition incorporates newly recognized parasites, discusses new and improved diagnostic methods, and covers relevant regulatory requirements and has expanded sections detailing artifact material and histological diagnosis, supplemented with color images throughout the text.
In the past years, genome projects for numerous human parasites have been completed and now allow first in depth comparisons and evolutionary conclusions. The genomes of parasites reflect the coevolution with their host, metabolic capacities depending on their respective habitat in the host. Gut parasites have an anaerobic metabolism, while blood parasites have an aerobic metabolism, intracellular parasites escape the immune system, while extracellular parasites evade the immune system, usually by antigenic variation. Comprehensive genome data now being available allow us to address profound scientific questions, such as which traits enable the parasite to survive in the human host, which to cause disease and which can be used as drug targets? This book intends to give an overview of the state of knowledge on “the molecules” of parasites – on their genomes, proteomes, glycomes and lipidomes. ​