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Flaviviruses are a diverse group of small RNA enveloped viruses, many of which are important human and animal pathogens. The best known include dengue virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus. These viruses are endemic in many tropical and sub-tropical regions of the world. Dengue virus alone infects over 100 million people annually. In recent years, research on flaviviruses has progressed at a remarkable rate, leading to significant advances in our understanding of virus biology. This should ultimately lead to the development of better vaccine and antiviral strategies. This up-to-date and cutting-edge anthology contains contributions from the leading experts in the flavivirus field. Chapters are balanced by contributions from established investigators who have dedicated their careers to flavivirus research with those from newcomers who have recently made significant contributions to the flavivirus field. The book is divided into two sections: Molecular Virology and Virus Prevention. The first section on Molecular Virology covers: virion structure * virus replication * the NS1 glycoprotein * the NS3 protein * the NS5 protein * innate immunity and flavivirus infection * host responses to flavivirus infection * flavivirus fitness and transmission. The Virus Prevention section includes: vaccines * antibody therapy * small molecule antiviral development * flavivirus diagnostics * vector-virus interactions * vector control. The book represents an important update of flavivirus research and will serve as a reference to flavivirus researchers at the graduate level and beyond. It is a recommended text for all virology libraries.
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase. - Includes new, detailed information on the evolution, viral structure and replication of the Flavivirus family - The only complete reference book on a major virus family - Descibes the technologies that have contributed to our current knowledge about Flaviviruses - Identifies the major problems faced in understanding the virus-host interactions that result in disease
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research. - Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions - Descibes the technologies that have contributed to our current knowledge about the Flaviviruses - Identifies the major problems faced in understanding the virus-host interactins that result in disease - An exhaustive compendium of current and past knowledge on the Flavivirus family
Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series
Provides a fully revised Eleventh Edition of the definitive reference to swine health and disease Diseases of Swine has been the definitive reference on swine health and disease for over 60 years. This new edition has been completely revised to include the latest information, developments, and research in the field. Now with full color images throughout, this comprehensive and authoritative resource has been redesigned for improved consistency and readability, with a reorganized format for more intuitive access to information. Diseases of Swine covers a wide range of essential topics on swine production, health, and management, with contributions from more than 100 of the foremost international experts in the field. This revised edition makes the information easy to find and includes expanded information on welfare and behavior. A key reference for anyone involved in the swine industry, Diseases of Swine, Eleventh Edition: Presents a thorough revision to the gold-standard reference on pig health and disease Features full color images throughout the book Includes information on the most current advances in the field Provides comprehensive information on swine welfare and behavior Offers a reorganized format to make the information more accessible Written for veterinarians, academicians, students, and individuals and agencies responsible for swine health and public health, Diseases of Swine, Eleventh Edition is an essential guide to swine health. "The 11th edition of Diseases of Swine continues to serve as the gold-standard resource for anything and everything related to swine herd health...this edition does an outstanding job of keeping up with the advanced diagnostic technologies and the latest research on new or emerging diseases and syndromes...there is no other informational resource that comes close to providing the depth or quality of information on the topic of swine diseases as does this book"
This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. Although many books cover several different types of polymerases, no book so far has attempted to catalog all nucleic acid polymerases. The goal of this book is to be the top reference work for postgraduate students, postdocs, and principle investigators who study polymerases of all varieties. In other words, this book is for polymerase fans by polymerase fans. Nucleic acid polymerases play a fundamental role in genome replication, maintenance, gene expression and regulation. Throughout evolution these enzymes have been pivotal in transforming life towards RNA self-replicating systems as well as into more stable DNA genomes. These enzymes are generally extremely efficient and accurate in RNA transcription and DNA replication and share common kinetic and structural features. How catalysis can be so amazingly fast without loss of specificity is a question that has intrigued researchers for over 60 years. Certain specialized polymerases that play a critical role in cellular metabolism are used for diverse biotechnological applications and are therefore an essential tool for research.
Mosquitoes, Communities, and Public Health in Texas focuses on 87 known species of mosquitoes found throughout Texas. It includes information on the ecology, medical and public health importance, and biological diversity of each species. In addition, it provides detailed identification keys for both larval and adult stages of all mosquito genera and species known to occur in Texas, along a review of surveillance and control strategies. The expansion of invasive mosquitoes from other regions (including Mexico), together with climate change occurrences increase the likelihood for an increase in diseases, such as West Nile Virus, Yellow Fever, Dengue, Chikungunya and Zika. This unique work is the first unified reference and resource rich in mosquito information for medical entomologists, mosquito and vector control professionals, pest management professionals, biologists, environmentalists, wildlife professionals, government regulators, instructors of medical entomology and public health professionals who have disease or vector responsibilities, mosquito taxonomists, epidemiologists, entomology students, academia, pest control industry, and libraries, etc., with utility for medical, veterinary and health professionals. - Brings into one volume the previously fragmented or unavailable information on the species of mosquitoes found in Texas and neighboring states of Mexico - Provides a variety of audiences with key data on mosquito biology, distribution and how to identify each - Includes a geographic distribution map, habitat associations, and medical importance on Zika, West Nile virus, Dengue and Chikungunya for each species
Japanese encephalitis and West Nile viruses are members of the Japanese encephalitis serological group of the genus Flavivirus and therefore closely related genetically and antigenically. They share a number of properties, including the use of birds as their major wildlife maintenance host and Culicine mosquitoes for transmission, and they are both associated with severe human disease, as well as fatal infections in horses. The emergence of these two viruses, and their well-established propensity to colonise new areas, make it timely to re-examine their ecology, biology, molecular structure, replication and epidemiology, and these therefore provide the focus of this volume.
Der neue Band aus der Reihe International Society of Neuropathology wurde anlässlich der British Medical Association (BMA) Awards 2019 wärmstens empfohlen. Die Herausgeber sind Experten des Fachgebiets und beschreiben Infektionen des Nervensystems mit ihren klinischen, pathologischen und genetischen Eigenheiten. Auch seltene Erkrankungen werden in übersichtlichen Kapiteln erläutert, zusammen mit Definitionen, mikrobiologischen Eigenschaften, Epidemiologie, klinischen Ausprägungen, Labortests, Pathologie, Genetik und Behandlungsoptionen.
Continued geographic expansion of dengue viruses and their mosquito vectors has seen the magnitude and frequency of epidemic dengue/dengue hemorrhagic fever (DF/DHF) increase dramatically. Recent exciting research on dengue has resulted in major advances in our understanding of all aspects of the biology of these viruses, and this updated second edition brings together leading research and clinical scientists to review dengue virus biology, epidemiology, entomology, therapeutics, vaccinology and clinical management.