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Human immunodeficiency virus and AIDS have received much attention in the last decade. As the major cause of death in young adults, this concern is merited. AIDS has also ushered onto the clinical agenda a number of unusual and interesting pathogens. These have had considerably less attention than the virus itself, but are arguably as important. This book attempts to put into one volume a state of the art review of the basic biology of these opportunistic organisms. When compiling this book, the perceived difficulty was deciding how to restrict the number of chapters, as there is a large number of opportunistic organisms. It soon became clear, however, that the chapters would select themselves, as the work on many of these organisms was still in its infancy. We can be criticized for including Salmonella, which is not thought to be an opportunistic infection, and excluding Cryptococcus. Our defence is that the former has an interesting relationship with HIV and the latter is one of those organisms for which the basic biology is still in its early stages. The authors are all active researchers in their respective fields and we are grateful that they managed to review their subjects in the short turn-around time required for a book such as this not to be needlessly outdated on publication. We hope that, if nothing else, this book stimulates interest and more research on these agents: perhaps, in future editions, there will be much more to describe on their molecular biology.
The human immunodeficiency virus (HIV) causes a life threating condition known as acquired immune deficiency syndrome (AIDS). The first stage of HIV infection is acute infection, following latency and then AIDS, which is the last and critical stage. Patients of AIDS generally have fully dysfunctional immune systems and they acquire a number of severe illnesses known as opportunistic infections (OIs). These illnesses occur in HIV patients with greater severity. Various OIs include tuberculosis (TB), pneumonia, toxoplasmosis, salmonella infection and candidiasis. These infections are caused by various germs, which can be transmitted through contaminated water and food, body fluids and air. AIDS normally takes years to grow following an infection with the human immunodeficiency virus (HIV). Infected AIDS patients are more likely to acquire cancers, such as Kaposi's sarcoma, cervical cancer, and cancers caused by damaged immune-system known as lymphomas. AIDS patients can benefit from certain medications like antiretroviral medicines. This book contains some path-breaking studies on the molecular and cell biology of opportunistic infections in HIV/AIDS. It will provide comprehensive knowledge to the readers. This book will serve as a reference to a broad spectrum of readers.
This study, based on both clinical and molecular trials, outlines the principles of the molecular biology of HIV and AIDS. Topics such as the origins of the virus, viral interactions with the immune system, antiviral intervention and vaccine prospects are covered.
Since the discovery of HIV-l as the etiologic agent of acquired immunodeficiency syndrome (AIDS) in the early 1980s, remarkable progress has been made in both the basic understanding of the biological processes leading to AIDS and an accelerated effort in finding new treatments. As is often the case in rapidly advancing fields, most of the scientific discussions are best handled in specialized groups. The effort to organize a meeting on advances in molecular biology and targeted treatment for AIDS was an experiment of sorts to gather experts in selected areas of overlapping interests where advances in basic biology and its application in the development of new drugs could be discussed. Of necessity, the scope of the meeting had to be limited to maintain a certain focus. Important areas of rapid development in AIDS research, such as the vaccine development, epidemiology, animal models, etc. , had to be left out for more specialized meetings. The result, from all accounts, appeared to be quite a successful gathering, which provided a forum for informal discussions among scientists from industry and academic institutions. A remarkable feature of the AIDS virus is its genetic complexity and how some of its seemingly "extra genes" manage to regulate the normal functions of the host and most importantly its immune system.
This comprehensive text, appropriate for an undergraduate course (or part of such a course), provides the nonspecialized student with a scientific overview of AIDS from a biomedical perspective. Assumes only a high school-level modern biology course. Annotation copyrighted by Book News, Inc., Portland, OR
Acquired immunodeficiency syndrome, or AIDS, is a disease of the im¬mune system that is caused by the human immunodeficiency virus (HIV). AIDS has caused significant loss of life with considerable social and eco¬nomic consequences worldwide. HIV must infect a host cell in order to replicate, and once infected, the host cell is unable to function properly. Since HIV infects specific cells of the host immune system, HIV infec¬tion impairs the ability of the patient to fight infections and kill cancer cells, therefore most deaths associated with HIV infection occur due to cancer or opportunistic infections. There is no cure for HIV, but advance¬ments in treatments mean that an HIV positive person could experience a normal lifespan with sustained daily care and medication designed to prevent HIV replication and spread. These medications primarily target viral proteins that allow HIV to infect host cells, replicate, and spread in the body. Work continues to find a way to eliminate HIV from patients and develop new pharmaceutical targets to address concerns of drug re¬sistant strains of HIV. Worldwide awareness of how the virus infects, is treated, and spreads within populations is a critical component to control the current AIDS pandemic.
This book provides an overview of background information on the epidemiology, biology, and pathophysiology of HIV infection. It presents the spectrum of HIV disease from acute infection to specific syndrome. The book reviews the management of specific opportunistic infections.
A multi-author approach is taken in this book to give a thorough view of the neuropathology of AIDS. The authors have exhaustively reviewed all the available data in order to draw a clear and complete picture of the present status. The broad approach makes the reader aware that the neurological disease is part of a process involving the patients in their entirety.
The worldwide impact of infection with human immunodeficiency virus type 1 (HIV- is reflected in the cumulative number ofHIV- 1 infections, which is now predicted to exceed 40 million by the year 2000---equivalent to the n- ber of humans who perished in World War II. The medical and scientific - sponse to the HIV-1 pandemic has steadily grown since its recognition in 1981. The outlay by the United States alone for HIV research funded by the National Institutes of Health in 1997 was $1. 4 billion. Laboratory-based HIV research has brought together academic clinicians, retrovirologists, molecular biologists, and immunologists in the formation of research teams attempting to dissect the viral and host factors contributing to disease pathogenesis. Increasing focus is being placed on those aspects of viral biology and host immune responses that bear on the development of vaccines to prevent HIV infection. HIVProtocols reflects the state of HIV research in several ways. First, chapters are organized into four sections: Virology, Molecular Biology, Humoral Immunology, and Cellular Immunology. This organization is a natural consequence of the diverse scientific disciplines that have been attracted to HIV research. Second, the chapters reflect such diverse research directions as viral coreceptor usage, quantitation of viral genomes, HIV promoter function, B-cell epitope mapping, and measurements of T-cell function, each of which bears on the goal of understanding the viral and host immune responses that will be critical to the design of effective preventive vaccines.