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Model formulae represent a powerful methodology for describing, discussing, understanding, and performing that large part of statistical tests known as linear statistics. The book aims to put this methodology firmly within the grasp of undergraduates.
This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
Suitable for self study Use real examples and real data sets that will be familiar to the audience Introduction to the bootstrap is included – this is a modern method missing in many other books
Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize specialized software, providing students with much-needed familiarity and experience with computing applications, critical components of the "modern biology" skill set. This book is appropriate for mathematics courses such as finite mathematics, discrete structures, linear algebra, abstract/modern algebra, graph theory, probability, bioinformatics, statistics, biostatistics, and modeling, as well as for biology courses such as genetics, cell and molecular biology, biochemistry, ecology, and evolution. Examines significant questions in modern biology and their mathematical treatments Presents important mathematical concepts and tools in the context of essential biology Features material of interest to students in both mathematics and biology Presents chapters in modular format so coverage need not follow the Table of Contents Introduces projects appropriate for undergraduate research Utilizes freely accessible software for visualization, simulation, and analysis in modern biology Requires no calculus as a prerequisite Provides a complete Solutions Manual Features a companion website with supplementary resources
This book emphasizes the importance of the likelihood function in statistical theory and applications and discusses it in the context of biology and ecology. Bayesian and frequentist methods both use the likelihood function and provide differing but related insights. This is examined here both through review of basic methodology and also the integr
Phylogenetic comparative approaches are powerful analytical tools for making evolutionary inferences from interspecific data and phylogenies. The phylogenetic toolkit available to evolutionary biologists is currently growing at an incredible speed, but most methodological papers are published in the specialized statistical literature and many are incomprehensible for the user community. This textbook provides an overview of several newly developed phylogenetic comparative methods that allow to investigate a broad array of questions on how phenotypic characters evolve along the branches of phylogeny and how such mechanisms shape complex animal communities and interspecific interactions. The individual chapters were written by the leading experts in the field and using a language that is accessible for practicing evolutionary biologists. The authors carefully explain the philosophy behind different methodologies and provide pointers – mostly using a dynamically developing online interface – on how these methods can be implemented in practice. These “conceptual” and “practical” materials are essential for expanding the qualification of both students and scientists, but also offer a valuable resource for educators. Another value of the book are the accompanying online resources (available at: http://www.mpcm-evolution.com), where the authors post and permanently update practical materials to help embed methods into practice.
Requiring no prior training, Modern Statistics for the Social and Behavioral Sciences provides a two-semester, graduate-level introduction to basic statistical techniques that takes into account recent advances and insights that are typically ignored in an introductory course. Hundreds of journal articles make it clear that basic techniques, routinely taught and used, can perform poorly when dealing with skewed distributions, outliers, heteroscedasticity (unequal variances) and curvature. Methods for dealing with these concerns have been derived and can provide a deeper, more accurate and more nuanced understanding of data. A conceptual basis is provided for understanding when and why standard methods can have poor power and yield misleading measures of effect size. Modern techniques for dealing with known concerns are described and illustrated. Features: Presents an in-depth description of both classic and modern methods Explains and illustrates why recent advances can provide more power and a deeper understanding of data Provides numerous illustrations using the software R Includes an R package with over 1300 functions Includes a solution manual giving detailed answers to all of the exercises This second edition describes many recent advances relevant to basic techniques. For example, a vast array of new and improved methods is now available for dealing with regression, including substantially improved ANCOVA techniques. The coverage of multiple comparison procedures has been expanded and new ANOVA techniques are described. Rand Wilcox is a professor of psychology at the University of Southern California. He is the author of 13 other statistics books and the creator of the R package WRS. He currently serves as an associate editor for five statistics journals. He is a fellow of the Association for Psychological Science and an elected member of the International Statistical Institute.
The Analysis of Biological Data provides students with a practical foundation of statistics for biology students. Every chapter has several biological or medical examples of key concepts, and each example is prefaced by a substantial description of the biological setting. The emphasis on real and interesting examples carries into the problem sets where students have dozens of practice problems based on real data. The third edition features over 200 new examples and problems. These include new calculation practice problems, which guide the student step by step through the methods, and a greater number of examples and topics come from medical and human health research. Every chapter has been carefully edited for even greater clarity and ease of use. All the data sets, R scripts for all worked examples in the book, as well as many other teaching resources, are available to qualified instructors (see below).