Download Free Model Based Analysis Of Fiber Optic Extended Wavelength Diffuse Reflectance Spectroscopy For Nerve Detection Book in PDF and EPUB Free Download. You can read online Model Based Analysis Of Fiber Optic Extended Wavelength Diffuse Reflectance Spectroscopy For Nerve Detection and write the review.

Optical spectroscopy is a real-time technique that holds promise as a potential surgical guidance tool. Fiber-optic diffuse reflectance spectroscopy (DRS) is a technique capable of intraoperative tissue differentiation. The common DRS focuses on estimating chromophore concentrations in the visible (VIS) wavelength range (400-1000 nm), where spectroscopic features of the blood, pigments, and tissue densities are present between 400 and 700 nm. Recently, extended-wavelength DRS (EWDRS), which extends the spectral window from the VIS through the short wave-infrared region (SWIR) up to 1800 nm, has emerged as a promising approach for identifying nerves and nerve bundles due to the SWIR including robust tissue absorption features associated with nerve-tissue related chromophores, including lipids, water and collagen proteins. One potential application of EWDRS is guiding minimally invasive surgical techniques, such as laparoscopy, where inadvertent injury to pelvic autonomic nerves (PANs) is a primary complication that can result in over 70% of patients suffering long-term side effects, including urinary incontinence and sexual dysfunction. There is a need for objective laparoscopic surgical guidance to precisely identify PANs from other tissues, and an improved basis for EWDRS development could assist clinical translation. Prior development of Fiber-optic DRS for tissue classification in the VIS greatly benefited from the application of modeling techniques for simulation of optical measurements, analysis, and fiber-probe design. Model-based analysis can inform fundamental understanding of measured signals in different measurement scenarios, such as the varying tissue morphologies possible in laparoscopic procedures, and guide application-specific fiber-probe design through comparison of unique illumination/collection geometries; however, the demonstration of these approaches in EWDRS is not widely reported. This dissertation focuses on the advancement of platforms for model-driven analysis of EWDRS for nerve identification. In order to advance the current state of EWDRS, a model-based characterization platform for analysis of a custom-developed fiber-optic EWDRS system was developed in Aim 1, which demonstrated agreement between data collected from optical phantoms, ex vivo microsurgical model, and Monte Carlo (MC) computational simulations of EWDRS measurements. In Aim 2, the model-based platform was used to perform a detailed analysis of two similar EWDRS fiber-optic probes, which indicated subtle differences in the depth-dependent measurement performance. Finally, in Aim 3, the custom EWDRS was prepared for adapting laparoscopic use to demonstrate laparoscopic measurement feasibility, including evaluation of placement variance and customized EWDRS package for short-distance transportation. The successful completion of this dissertation will enable improved analyses of EWDRS devices for a variety of future intraoperative applications.
The 26th Southern Biomedical Engineering Conference was hosted by the Fischell Department of Bioengineering and the A. James Clark School of Engineering from April 30 – May 2 2010.. The conference program consisted of 168 oral presentations and 21 poster presentations with approximately 250 registered participants of which about half were students. The sessions were designed along topical lines with student papers mixed in randomly with more senior investigators. There was a Student Competition resulting in several Best Paper and Honorable Mention awards. There were 32 technical sessions occurring in 6-7 parallel sessions. This Proceedings is a subset of the papers submitted to the conference. It includes 147 papers organized in topical areas. Many thanks go out to the paper reviewers who significantly improved the clarity of the submitted papers.
This monograph equips clinicians with the knowledge required to detect oral cancer at the earliest possible stage while simultaneously inspiring researchers to work on novel methods of detection. All the methods employed in the oral cancer context are considered, from simple ones like oral screening to more complex emerging optical methods and biomarker identification strategies. Individual chapters focus on conventional oral screening and application of vital stains, optical methods like white light based fluorescence-reflectance imaging, narrow band imaging, direct-oral-microscopy, and more advanced methods like optical coherence tomography, an in-vivo optical biopsy technique, and photo-acoustic imaging that allows visualization of deeper tissue changes. Novel electrical methods like bio-impedance assessment, occult biophysical methods like crystallization test, and the most promising salivary biomarkers and point-of-care opportunities are covered. Helpful information is also provided on essential topics including, oral potentially malignant disorders, biological aspects and molecular mechanisms underlying oral cancer progression, global epidemiology, concept of diagnostic delays, traditional imaging, and classic histopathology and microscopic features. The newer techniques are currently of active research interest, and can soon become powerful chair-side tools with potential to reduce diagnostic delays and improve survival.
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
This interesting book covers latest aspects of a highly sophisticated technology; results treated in critical detail; demonstrates applicability of this technology to practical problems in process control, biochip methods, clinical analysis, environmental sciences
This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.
Reviews the most prominent research results related to skin in the fields of computer vision, computer graphics, cosmetology and medicine, and shows how these seemingly disconnected studies are related to one another. It will be of interest to anybody researching, or planning to conduct research, on the appearance of human skin.