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Handbook on Miniaturization in Analytical Chemistry: Application of Nanotechnology provides a source of authoritative fundamentals, interdisciplinary knowledge and primary literature for researchers who want to fully understand how nano-technologies work. Covering all stages of analysis, from sample preparation to separation and detection, the book discusses the design and manufacturing technology of miniaturization and includes an entire section on safety risks, ethical, legal and social issues (ELSI), the economics of nanotechnologies, and a discussion on sustainability with respect to nano- and lab-on-chip technologies. This guide for students and researchers working on applications of nanotechnology in modern systems for analysis gives readers everything they need to know to bring their current practices up-to-date.
Miniaturization is a challenge thrown down to analytical chemistry. The replacement of conventional analytical systems by miniaturized alternatives during the last years is noticeable. Specifically, the miniaturization of traditional sample preparation techniques (e.g., solid-phase extraction or solvent extraction) led to the development of environmentally benign analytical methods. This book aims to provide an overview of the challenges and achievements inthe application of the miniaturized sample preparation methods in analytical laboratories. It includes both theoretical and practical aspects of miniaturized sample preparation approaches and hence should be of interest to researchers, students and teachers of analytical and bioanalytical chemistry, environmental sciences and environmental engineering.
The recent explosion in the use of analytical chemistry, particularly in the biological sciences, has led to a need for fast, reliable and highly sensitive tools able to handle small sample sizes. This book illustrates how microfluidics and lab-on-a-chip devices can satisfy the growing need for miniaturized and enhanced analysis. They lend themselves well to mass spectrometric detection as they use samples in the low microlitre range and are handled on a chip. Miniaturization and Mass Spectrometry focuses on one particular technique, mass spectrometry, whose popularity has increased dramatically in the last two decades with the increase in use of biological analysis and the development of two "soft" ionization techniques, ESI and MALDI. These enable the analysis of large but fragile biological molecules such as DNA, proteins and oligosaccharides. The book starts with an introduction to the coupling of microfluidics to mass spectrometry techniques. It then goes on demonstrate the advantages of such a coupling: the MS analysis benefits from improved sample preparation when performed on a chip while MS yields more information on the sample handled on the chip compared to conventional optical detection. A history on the developments in this field, starting from the off-chip coupling to the on-chip ionization, is also provided. Daniel Figeys, a pioneer in the development of microfluidic systems for MS analysis, describes the early beginnings of this hyphenated analysis technique. Solutions to couple microfluidic systems to the two most popular ionization methods, ESI and MALDI, are presented throughout the chapters. Various examples are given of the application of this microfluidics-MS hyphenated analysis technique to proteomics, metabolomics, organic chemistry and forensics. Coverage is not limited to academic research. The development of commercialized systems and their current use for routine biological analysis are also presented. Lastly, a future vision of the integration of the mass spectrometer on the chip is raised, as a last step to yield fully portable systems for on-site analysis.
Miniaturized Analytical Devices An in-depth overview of integrating functionalized nanomaterials with mass spectrometry, spectroscopy, electrophoresis, and other important analytical techniques Miniaturized Analytical Devices: Materials and Technology is an up-to-date resource exploring the analytical applications of miniaturized technology in areas such as clinical microbiology, pharmaceuticals, agriculture, and environmental analysis. The book covers the integration of functional nanomaterials in mass spectrometry, microscopy, electrophoresis, and more—providing the state-of-the-art information required for successfully implementing a range of chemical analysis techniques on microchips. Featuring contributions from a panel of international experts in the field, the book begins with an introduction to selected miniaturized devices, nanomaterials, and analytical methods. Subsequent sections describe functionalized nanomaterials (FNMs) for miniaturized devices and discuss techniques such as miniaturized mass spectrometry for bioassays and miniaturized microscopy for cell imaging. The book concludes by exploring a variety of applications of miniaturized devices in areas including metal analysis, bioimaging, DNA separation and analysis, molecular biology, and more. This timely volume: Surveys the current state of the field and provides a starting point for developing faster, more reliable, and more selective analytical devices Focuses on the practical applications of miniaturized analytical devices in materials science, clinical microbiology, the pharmaceutical industry, and environmental analysis Covers a wide range of materials and analytical techniques such as microvolume UV-VIS spectroscopy, microchip and capillary electrophoresis, and matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) analysis Discusses the role of miniaturized analytical devices in securing a green and sustainable future Miniaturized Analytical Devices: Materials and Technology is essential reading for analytical chemists, analytical laboratories, materials scientists, biologists, life scientists, and advanced students in related fields.
This book addresses Lab-on-a-Chip devices. It focuses on microfluidic technologies that have emerged in the past decade. Coverage presents a comprehensive listing of the most promising microfluidic technologies in the Lab-on-a-Chip field. It also details technologies that can be viewed as toolboxes needed to set up complex Lab-on-a-Chip systems.
System-on-Package (SOP) is an emerging microelectronic technology that places an entire system on a single chip-size package. Where “systems” used to be bulky boxes housing hundreds of components, SOP saves interconnection time and heat generation by keep a full system with computing, communications, and consumer functions all in a single chip. Written by the Georgia Tech developers of the technology, this book explains the basic parameters, design functions, and manufacturing issues, showing electronic designers how this radical new packaging technology can be used to solve pressing electronics design challenges.
An in-depth survey of the design and REALIZATIONS of miniaturized fractal microwave and RF filters Engineers are continually searching for design methods that can satisfy the ever-increasing demand for miniaturization, accuracy, reliability, and fast development time. Design and Realizations of Miniaturized Fractal RF and Microwave Filters provides RF and microwave engineers and researchers, advanced graduate students, and wireless and telecommunication engineers with the knowledge and skills to design and realize miniaturized fractal microwave and RF filters. This book is an essential resource for the realization of portable and cellular phones, WiFi, 3G and 4G, and satellite networks. The text focuses on the synthesis and fabrication of miniaturized fractal filters with symmetrical and asymmetrical frequency characteristics in the C, X and Ku bands, though applications to other frequency bands are considered. Readers will find helpful guidance on: Miniaturized filters in bilevel fashion Simplified methods for the synthesis of pseudo-elliptic electrical networks Methods for extracting coupling coefficients and external quality factors from simulations of the RF/microwave structure Methods for matching theoretical couplings to couplings of structure Including studies of the real-world performance of fractal resonators and sensitivity analyses of suspended substrate realizations, this is a definitive resource for both practicing engineers and students who need timely insight on fractal resonators for compact and low-power microwave and RF applications.
Miniaturisation is the creation of small objects that resemble larger ones, usually, but not always, for purposes different to those of the larger original object. Worlds in Miniature brings together researchers working across various regions, time periods and disciplines to explore the subject of miniaturisation as a material culture technique. It offers original contribution to the field of miniaturisation through its broad geographical scope, interdisciplinary approach, and deep understanding of miniatures and their diverse contexts. Beginning with an introduction by the editors, which offers one possible guide to studying and comparing miniatures, the following chapters include studies of miniature Neolithic stone circles on Exmoor, Ancient Egyptian miniature assemblages, miniaturisation under colonialism as practiced by the Makah People of Washington State, miniature surf boats from India, miniaturised contemporary tourist art of the Warao people of Venezuela, and dioramas on display in the Science Museum. Interspersing the chapters are interviews with miniature-makers, including two miniature boat-builders at the National Maritime Museum Cornwall and a freelance architectural model-maker. Professor Susanne Küchler concludes the volume with a theoretical study summarising the current state of miniaturisation as a research discipline. The interdisciplinary nature of the volume makes it suitable reading for anthropologists, archaeologists, historians and artists, and for researchers in related fields across the social sciences. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Using the visual and tactile experience of small-scale figurines, Greeks and Babylonians negotiated a hybrid, cross-cultural society in Hellenistic Mesopotamia.
What is the future of CMOS? Sustaining increased transistor densities along the path of Moore's Law has become increasingly challenging with limited power budgets, interconnect bandwidths, and fabrication capabilities. In the last decade alone, transistors have undergone significant design makeovers; from planar transistors of ten years ago, technological advancements have accelerated to today's FinFETs, which hardly resemble their bulky ancestors. FinFETs could potentially take us to the 5-nm node, but what comes after it? From gate-all-around devices to single electron transistors and two-dimensional semiconductors, a torrent of research is being carried out in order to design the next transistor generation, engineer the optimal materials, improve the fabrication technology, and properly model future devices. We invite insight from investigators and scientists in the field to showcase their work in this Special Issue with research papers, short communications, and review articles that focus on trends in micro- and nanotechnology from fundamental research to applications.