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Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery. - Microbial gene sequencing - Up-to-date picture of the global burden of infectious diseases - Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence - Latest data on combination vaccines, the promise of edible vaccines - The spread of antibiotic resistance genes among bacteria - HIV1 and HIV2; molecular biology, pathogenesis and origin - Latest data on tuberculosis - the number one infectious disease worldwide - Recent work on papillomaviruses, herpesviruses, BSE and variant CJD - Latest data on microbial evasion of immune defences - Origin and molecular biology of pandemic influenza - Significance of toxins - An update on vaccines, prions, immune evasion, microbial ligands and receptors
This textbook provides a comprehensive description of the mechanisms of microbial infection and the pathogenesis of infectious disease. This edition presents an up-to-date picture of the global burden of infectious diseases.
The newly revised edition of this work provides an up-to-date description of the mechanisms of infection and disease production in a clear and logical manner. Dealing in an integrated manner with all microorganisms, the factors common to all infectious diseases are set out. Molecular biology, pathology, and immunology are brought together to explain how an infectious agent causes disease, and how the body reacts to it. - Attachment to and entry of microorganisms - Events occurring immediately after entry - The encounter of the microbe with the phagocytic cell - The spread of microbes through the body - The immune response to infection - Microbial strategies in relation to the immune response - Mechanisms of cell and tissue damage - Recovery from infection - Failure to eliminate the microbe - Host and microbial factors influencing susceptibility - Vaccines
Learn all the microbiology and basic immunology concepts you need to know for your courses and exams. Now fully revised and updated, Mims' clinically relevant, systems-based approach and abundant colour illustrations make this complex subject easy to understand and remember. - Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the 'bug parade' into a clinical context. - Effectively review for problem-based courses with the help of chapter introductions and 'Lessons in Microbiology' text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools. - Approach microbiology by body system or by pathogen through the accompanying electronic 'Pathogen Parade' – a quickly searchable, cross-referenced glossary of viruses, bacteria and fungi - A new electronic 'Vaccine Parade' offers quick-reference coverage of the most commonly used vaccines in current clinical practice - Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventative medicine. - Grasp and retain vital concepts easily, with a user-friendly colour coded format, succinct text, key concept boxes, and dynamic illustrations. - New and enhanced information reflects the growing importance of the human microbiota and latest molecular approaches - Access the complete contents on the go via the accompanying interactive eBook, with a range of bonus materials to enhance learning and retention – includes self-assessment materials and clinical cases to check your understanding and aid exam preparation.
The newly revised edition of this work provides an up-to-date description of the mechanisms of infection and disease production in a clear and logical manner. Dealing in an integrated manner with all microorganisms, the factors common to all infectious diseases are set out. Molecular biology, pathology, and immunology are brought together to explain how an infectious agent causes disease, and how the body reacts to it.
Herpes Simplex Virus is the fifth monograph to be published in the Bloomsbury Series of Clinical Science. It provides an authoritative review of the key issues related to this common clinical problem. The characteristics of the virus, its epidemiology and the diag nosis and management of the various forms of infection are all considered. Adrian Mindel is an international authority on this subject; he joined the Academic Department of Genito-urinary Medicine at the Middlesex Hospital in 1980 and has been actively involved in HSV research since that time. His major research interests include the epidemiology and treatment of genital herpes, the epidemi ology of neo-natal herpes and the many and varied features of HSV infections in immuno-compromised patients. The continuing aim of the Bloomsbury Series is to identify the growing areas of clinical research and relate these to current and future medical practice. In Herpes Simplex Virus such aspirations have been successfully achieved. London, May 1989 Jack Tinker Preface There has been considerable interest in herpes simplex viruses (HSV) over recent years. Amongst the many reasons for this are the introduction of safe and efficacious therapy, the recognition that HSV may cause life-threatening infections in neonates and immunocompromised patients, the observation that genital herpes is one of the commonest viral sexually transmitted diseases and the possible association of HSV with cervical cancer.
Outbreak: Cases in Real-World Microbiology, 2nd Edition, is the newest edition of this fascinating textbook designed for introductory microbiology students and instructors. Thoroughly revised, this collection of case studies of real-world disease outbreaks, generously illustrated in full color, offers material that directly impacts college-level students, while the book's unique presentation offers instructors the flexibility to use it effectively in a number of ways. More than 90 outbreak case studies, organized into six sections according to the human body system affected, illustrate the wide range of diseases caused by microbial pathogens. The studies are presented at differing levels of difficulty and can be taught at all undergraduate levels. Each case study includes questions for students to think about, discuss, and answer, and the book includes an appendix that directs students to the specific reference material on which each case was based, providing the opportunity to investigate further and to apply the reference content to the case being studied. Each of the six sections of the book concludes with a College Perspective and a Global Perspective case study. The College Perspective provides a direct and practical link between the microbiology course and the daily lives of students. The Global Perspective connects students with outbreaks that have occurred in countries around the world to facilitate understanding of the social, religious, economic, and political values at play in the treatment and prevention of infectious disease. At the end of every section, detailed descriptions offer concise yet complete information on each disease involved in that section.
Infectious diseases are the leading cause of death worldwide. In The War Within Us, well-known author and infectious disease specialist Cedric Mims makes the intricacies of the immune system and infectious diseases less baffling for the general reader and answers the questions of how things work and why. The story is told in terms of the ancient conflict between the invader (the infectious disease) and the defender (the body's immune system) and the strategies and counter-strategies used by both sides, making it a book that is both informative and interesting to read. The War Within Us is an ideal introduction to the basics of immunity and infection for general readers and students. It also serves as a quick reference book for physicians, researchers, and other health workers. - Parasite versus host - The conflict: how we defend ourselves - The microbe's response to our defence - How microbes cause diseas - Thumbnail sketches of seven selected diseases: - The threat of new diseases
Publisher Description
The history of disease is the history of humankind: an interpretation of the world as seen through the extraordinary impact—political, demographic, ecological, and psychological—of disease on cultures. "A book of the first importance, a truly revolutionary work." —The New Yorker From the conquest of Mexico by smallpox as much as by the Spanish, to the bubonic plague in China, to the typhoid epidemic in Europe, Plagues and Peoples is "a brilliantly conceptualized and challenging achievement" (Kirkus Reviews). Upon its original publication, Plagues and Peoples was an immediate critical and popular success, offering a radically new interpretation of world history. With the identification of AIDS in the early 1980s, another chapter was added to this chronicle of events, which William McNeill explores in his introduction to this edition. Thought-provoking, well-researched, and compulsively readable, Plagues and Peoples is essential reading—that rare book that is as fascinating as it is scholarly, as intriguing as it is enlightening.