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This book describes the use of modern micro- and nanofabrication technologies to develop improved tools for stimulating and recording electrical activity in neuronal networks. It provides an overview of the different ways in which the “nano-world” can be beneficial for neuroscientists, including improvement of mechanical adhesion of cells on electrodes, tight-sealed extracellular recordings or intracellular approaches with strongly reduced invasiveness and tools for localized electrical or optical stimulation in optogenetics experiments. Specific discussion of fabrication strategies is included, to provide a comprehensive guide to develop micro and nanostructured tools for biological applications. A perspective on integrating these devices with state-of-the-art technologies for large-scale in vitro and in vivo experiments completes the picture of neuronal interfacing with micro- and nanostructures.
In the past decades, interdisciplinary investigations overlapping biology, medicine, information science, and engineering have formed a very exciting and active field that attracts scientists, medical doctors, and engineers with knowledge in different domains. A few examples of such investigations include neural prosthetic implants that aim to improve the quality of life for patients suffering from neurologic disease and injury; brain machine interfaces that sense, analyze, and translate electrical signals from the brain to build closed-loop, biofeedback systems; and fundamental studies of intelligence, cognitive functions, and psychological behaviors correlated to their neurological basis. Although this interdisciplinary area is still in its infancy, it can potentially create some of the most significant impact: treating diseases that are considered untreatable, interpretation and communication of neuron ensembles, or even a revolutionary perception and understanding of life different from philosophical or immaterial approaches. Fortunately, several academic societies recognize the value and impact of this growing field, firmly supporting related research. Such support will drive a booming future in the next twenty or thirty years. Research in this area is frequently project-driven, and the generated knowledge has been scattered in different fields of neuroscience, computation, material and technology, circuits and system, clinical reports, and psychology—the scope considerably across the boundary of traditionally defined disciplines. Neural Computation, Neural Devices, and Neural Prosthesis is intended to assemble such knowledge, from there suggesting a systematic approach guiding future educational and research activities. The targeted audience includes both students and researchers.
This book serves as a guide for practicing engineers, researchers and students interested in MEMS devices and biomaterials and biomedical applications. It is also suitable for engineers and researchers interested in MEMS and its applications but who do not have the necessary background in biomaterials. The book highlights important features and issues of biomaterials that have been used in MEMS and biomedical areas, including the fabrication of devices using biomaterials, biocompatible coatings and issues, thin-film biomaterials and MEMS for tissue engineering, and applications involving MEMS and biomaterials.
This book overviews the underlying chemistry behind the most common and cutting-edge inorganic materials in current use, or approaching use, in vivo.
This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
The Conference is the premier international meeting for the presentation of original work addressing all aspects of the theory, design, fabrication, assembly, packaging, testing and application of solid-state sensors, actuators, MEMS, and microsystems.