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1 A MODEL FOR DERIVING STANDARDS FOR ENVIRONMENTAL AND OCCUPATIONAL POLLUTANTS. 2 ANIMAL EXTRAPOLATION IN STANDARD SETTING. 3 HIGH RISK GROUPS. 4 CHEMICAL INTERACTIONS IN THE STANDARD DERIVATION PROCESS. 5 APPROACHES TO DERIVING SAFE LIMITS FOR POLLUTANT EXPOSURE. 6 DRINKING WATER STANDARDS: THEIR ORIGIN AND RATIONALE. 7 OCCUPATIONAL HEALTH STANDARDS. 8 BIOLOGICAL INDICATORS OF POLLUTANT EXPOSURE: THEIR ROLE IN OCCUPATIONAL STANDARD SETTING. 9 NOVEL WORK SCHEDULE TLVS. 10 NATIONAL AMBIENT AIR QUALITY STANDARDS. 11 COMPARISON OF UNITED STATES AND FOREIGN STANDARDS WITH EMPHASIS ON SOVIET APPROACHES. 12 ASBESTOS: A CASE STUDY.
Includes subject section, name section, and 1968-1970, technical reports.
Since the first edition in 1948, Patty’s Industrial Hygiene and Toxicology has become a flagship publication for Wiley. During its nearly seven decades in print, it has become a standard reference for the fields of occupational health and toxicology. The volumes on industrial hygiene are cornerstone reference works for not only industrial hygienists but also chemists, engineers, toxicologists, lawyers, and occupational safety personnel. Volume 1 covers Introduction of Industrial Hygiene and Recognition of Chemical Agents. In addition to revised and updated chapters, a number of new chapters reflect current technology and concerns. The chapters include Ethics in Industrial Hygiene, Prevention through Design, Risk Communication, Managing Workplace Demographics, and Mastering Digital Media for Workers, Employers and Community Practice.
Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.
A framework for making decisions about risks, with recommendations for research, public policy, and practice.