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Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
A guide to identifying disease processes in the placenta affecting pregnancy outcome, with current diagnostic criteria and clinical consequences.
Membrane Physiology (Second Edition) is a soft-cover book containing portions of Physiology of Membrane Disorders (Second Edition). The parent volume contains six major sections. This text encompasses the first three sections: The Nature of Biological Membranes, Methods for Studying Membranes, and General Problems in Membrane Biology. We hope that this smaller volume will be helpful to individuals interested in general physiology and the methods for studying general physiology. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL STANLEY G. SCHULTZ vii Preface to the Second Edition The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition. Yet the purpose of the second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably.
This book provides a comprehensive resource on the pathology of the human singleton placenta. Agreed nomenclature, nosology, definitions and, where possible, thresholds for meaningful clinical corrections for lesions ideal for practical application in clinical practice are presented. Evidence is also featured on relevant potential clinical correlations to aid the reader in deciding upon the most appropriate management strategy. Areas of current uncertainty are also covered for potential future research. Pathology of the Placenta systematically describes placental pathology, and represents a valuable resource for practising and trainee pathologists, obstetricians, neonatologists and epidemiologists.
The pathologist who sees specimens from lesions of the serosal membranes (pleura, pericardium, peritoneum, and tunica vaginalis) is well aware that these cases, whether in the form of fluid cytologies, small biopsies, or major resections, pose differential diagnostic problems that are among the most difficult in anatomic pathology. The main problems involve the separation of malignant mesothelioma from benign mesothelial processes on the one hand and other malignant tumours (particularly primary and metastatic carcinomas) on the other. With these differential diagnoses in mind, the authors concentrate on the cytopathologic and histopathologic features of diffuse malignant mesothelioma, its many variants, and the other benign and malignant lesions to be distinguished from it. Histochemical, immunohistochemical, ultrastructural and molecular features of potential use in this differentiation are discussed and illustrated. Common differential diagnostic problems and their solutions take precedence, but all of the known benign and malignant lesions of serosal membranes are covered, with copious illustrations and the latest available references. Epidemiologic, pathogenetic, clinical, radiographic and gross pathologic features are integrated with the discussions of these entities. This will be the most complete source available on this topic for years to come.
The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation
This book presents colored gross and microphotographs of histopathology sections of both common and uncommon tumors of the female genital tract, and also includes the immunohistochemistry of the important lesions. Further, it explains the salient diagnostic features and the immunocytochemistry, molecular pathology and differential diagnosis of each lesion with brief references and discusses recent advances in the diagnosis of these tumors. With numerous images offering guidance on diagnosing different lesions of the female genital tract, the book is intended for practicing pathologists and post-graduate students as well as for gynecology practitioners and post-graduate students.
Part of the highly regarded Diagnostic Pathology series, this updated volume covers all aspects of placental pathology and the critical role the placenta plays in the unique interface between mother and fetus. Concise, focused chapters, supported by tables, diagrams, and photographs, keep you up-to-date with evolving changes in the questions and issues concerning both the fetus/infant and the mother. This revised edition is ideal for pathologists at all levels of experience and training for use as a quick reference and as an efficient review to improve knowledge and skills. Provides clear and concise information on gross and microscopic changes of the placenta, common diagnoses, and placental evaluation in special circumstances Includes updated terminology and diagnostic criteria, new recommendations for the use of molecular techniques such as SNP array or whole genome sequencing for evaluation of stillbirth, and more images to illustrate challenging diagnoses Contains new chapters on pathology of maternal mortality, complications of twin pregnancies, and hypoxic-ischemic encephalopathy, as well as expanded chapters on gestational trophoblastic disease and new coverage of twin anemia polycythemia sequence (TAPS) Covers pregnancy complications such as preeclampsia, intrauterine growth restriction, and multiple gestations, highlighting placental findings, key correlates, relevant fetal organ pathology, and the pathology of the postpartum hysterectomy Time-saving reference features include bulleted text, annotated images, reference tables for placental evaluation, and sample templates useful for gross and microscopic placental description
An essential foundation text for residents and pathologists, the third edition of Head and Neck Pathology, a volume in the Foundations in Diagnostic Pathology series, has been fully revised to include recent advances in the field. Featuring a highly templated, easy-to-use format and new information throughout, this practical, affordable resource by Drs. Lester D. R. Thompson and Justin A. Bishop is ideal for study and review as well as everyday clinical practice. Inclusion of a wide range of diagnoses in both head and neck and endocrine organ pathology. A focus on the specific features of selected non-neoplastic and neoplastic entities, including broad and in-depth differential diagnoses. Clinical and Pathologic Features summarized in quick-reference boxes for fast access to information. A highly templated format that includes pertinent clinical, imaging, and management/prognostic features; pathologic features; ancillary studies; differential diagnosis; and meaningfully chosen bibliography. Over a thousand full-color photographs illustrate important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Contributions from internationally recognized expert pathologists, keeping you up to date with the latest information in the field. New criteria as established by the 2017 World Health Organization Classification of Head and Neck Tumours and the 2017 World Health Organization Classification of Endocrine Organ Tumours. A new oropharynx section, separated from the oral cavity. Inclusion of unique newly identified molecular information in many tumor entities. Coverage of NUT carcinoma, HPV-associated adenoid cystic-like carcinoma, sinonasal renal cell-like adenocarcinoma, SMARCB1 (INI-1) deficient sinonasal carcinoma, biphenotypic sinonasal sarcoma, neuroendocrine carcinomas, oropharyngeal carcinoma, polycystic disease and sclerosing polycystic adenosis, secretory carcinoma, cribriform adenocarcinoma of the minor salivary glands, variants of myoepithelioma, clear cell carcinoma, and changes in gnathic cysts classification.