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Intrinsically photosensitive retinal ganglion cells (ipRGGs) are the most recently discovered photoreceptor class in the human retina. This Element integrates new knowledge and perspectives from visual neuroscience, psychology, sleep science and architecture to discuss how melanopsin-mediated ipRGC functions can be measured and their circuits manipulated. It reveals contemporary and emerging lighting technologies as powerful tools to set mind, brain and behaviour.
Photopigments are molecules that react to light and mediate a number of processes and behaviours in animals. Visual pigments housed within the photoreceptors of the eye, such as the rods and cones in vertebrates are the best known, however, visual pigments are increasingly being found in other tissues, including other retinal cells, the skin and the brain. Other closely related molecules from the G protein family, such as melanopsin mediate light driven processes including circadian rhythmicity and pupil constriction. This Volume examines the enormous diversity of visual pigments and traces the evolution of these G protein coupled receptors in both invertebrates and vertebrates in the context of the visual and non-visual demands dictated by a species’ ecological niche.
This advanced text, first published in 2006, takes a developmental approach to the presentation of our understanding of how vertebrates construct a retina. Written by experts in the field, each of the seventeen chapters covers a specific step in the process, focusing on the underlying molecular, cellular, and physiological mechanisms. There is also a special section on emerging technologies, including genomics, zebrafish genetics, and stem cell biology that are starting to yield important insights into retinal development. Primarily aimed at professionals, both biologists and clinicians working with the retina, this book provides a concise view of vertebrate retinal development. Since the retina is 'an approachable part of the brain', this book will also be attractive to all neuroscientists interested in development, as processes required to build this exquisitely organized system are ultimately relevant to all other parts of the central nervous system.
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
John Dowling’s The Retina, published in 1987, quickly became the most widely recognized introduction to the structure and function of retinal cells. In this Revised Edition, Dowling draws on twenty-five years of new research to produce an interdisciplinary synthesis focused on how retinal function contributes to our understanding of brain mechanisms. The retina is a part of the brain pushed out into the eye during development. It retains many characteristics of other brain regions and hence has yielded significant insights on brain mechanisms. Visual processing begins there as a result of neuronal interactions in two synaptic layers that initiate an analysis of space, color, and movement. In humans, visual signals from 126 million photoreceptors funnel down to one million ganglion cells that convey at least a dozen representations of a visual scene to higher brain regions. The Revised Edition calls attention to general principles applicable to all vertebrate retinas, while showing how the visual needs of different animals are reflected in their retinal variations. It includes completely new chapters on color vision and retinal degenerations and genetics, as well as sections on retinal development and visual pigment biochemistry, and presents the latest knowledge and theories on how the retina is organized anatomically, physiologically, and pharmacologically. The clarity of writing and illustration that made The Retina a book of choice for a quarter century among graduate students, postdoctoral fellows, vision researchers, and teachers of upper-level courses on vision is retained in Dowling’s new easy-to-read Revised Edition.
Melanopsin is a visual pigment, expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) of the mammalian retina, that plays a major role in non-image forming visual behaviors like the pupillary light reflex, circadian photoentrainment, and sleep. It is hypothesized that melanopsin-mediated phototransduction is terminated by the phosphorylation of melanopsin’s C-terminus by a G-protein coupled receptor kinase, followed by -arrestin activation and binding. Little is known about the contribution of melanopsin phosphorylation to ipRGC physiology and its influence on non-image forming behaviors. We investigated the role of melanopsin C-terminus phosphorylation on non-image forming behaviors by generating a phosphorylation deficient melanopsin mutant that lacks all putative C-terminal phosphorylation sites (C-phosphonull).
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Circadian and Visual Neuroscience, Volume 273 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics including Optical set-ups, Psychophysics of Luminance and Color Vision, Psychophysics of non-visual photoreception PRC/IRC/DRC/Spectral Sensitivity, Circadian and visual photometry, Modelling (retina), Modelling (circadian), Techniques for examining vision at the cellular level, Advanced techniques for characterizing the world hyperspectrally, Circadian physiology in mice: Melanopsin, Circadian physiology in mice: Color and cones, Translational aspects of animal studies, Retinal clocks, Primate non-visual physiology, Light and mood in animal models, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research series Updated release includes the latest information on Circadian and Visual Neuroscience