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In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.
This invaluable book provides a readable, introductory text to the fascinating subject of drug discovery from the medicinal plants of Asia-Pacific. A carefully designed layout presents more than 400 medicinal plants, and includes description of compound structure, molecular properties, pharmacology and clinical uses. With its broad scope and extensive compound listings, this is a premier reference source for natural products research using a pharmacological approach. Starting from a collection of plants in the rainforests of Asia-Pacific, Wiart shows how the present state of knowledge fosters a whole new way of looking at the discovery of drugs from medicinal plants.Wiart uses his approach to deal with a remarkable array of fundamental problems: from the phylogeny of plants, to the molecular basis of activity, limitations of phytochemistry, and the possibility of a truly fundamental theory of ethnopharmacology.Written with exceptional clarity, and illustrated by more than 300 original pictures and 400 chemical structures, this seminal book allows scientists and non-scientists alike to participate in what promises to be a major intellectual revolution.
Drawing on the author's extensive personal experience, Medicinal Plants of Asia and the Pacific provides comprehensive coverage of the medicinal plants of the region. Describing more than 300 compounds, the book discusses every important class of natural products while highlighting cutting-edge research and recent developments. With its broa
Medicinal Plants in the Asia Pacific for Zoonotic Pandemics provides an unprecedented, comprehensive overview of the phylogeny, botany, ethnopharmacology, and pharmacology of more than 100 plants used in the traditional medical systems of Asia and Pacific. It discusses their actions and potentials against viruses, bacteria, and fungi that represent a threat of epidemic and pandemic diseases, with an emphasis on the molecular basis and cellular pathways. This book presents scientific names, the botanical classification, traditional medicinal uses, active chemical constituents, and pharmacology. This volume is a critical reference for anyone involved in the discovery of lead molecules or phytopharmaceutical products for the prevention or treatment of pandemic viral, bacterial, or fungal infections. FEATURES Phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal actions Discusses the chemical structure–activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi Contains a selection of botanical plates and useful bibliographic references This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics includes commentary sections that invite further research and reflection on the fascinating and timely subject of the development of drugs and herbals from Asia-Pacific medicinal plants to safeguard humanity and other life forms against the forthcoming waves of viral, bacterial, or fungal pandemics. This book is an ideal reference text for medicinal plant enthusiasts.
Non-Aboriginal material.
Volume 10 is part of a multi compendium Edible Medicinal and Non-Medicinal Plants. This work is of significant interest to medical practitioners, pharmacologists, ethnobotanists, horticulturists, food nutritionists, botanists, agriculturists, conservationists and general public. 59 plant species with edible modified stems, roots and bulbs in the families Amaranthaceae, Cannaceae, Cibotiaceae, Convolvulaceae, Cyperaceae, Dioscoreaceae, Euphorbiaceae, Fabaceae, Iridaceae, Lamiaceae, Marantaceae, Nelumbonaceae, Nyctaginaceae, Nymphaeaceae, Orchidaceae, Oxalidaceae, Piperaceae, Poaceae, Rubiaceae, Simaroubaceae, Solanaceae, Tropaeolaceae, Typhaceae and Zingiberaceae. Topics covered include: taxonomy; common/ vernacular names; origin/ distribution; agroecology; edible plant parts/uses; botany; nutritive/medicinal properties, nonedible uses and selected references.
Viruses and plagues have constantly threatened the survival of humanity since the evolution of modern man. Medical advances, thanks to the application of remedial plants, have helped to fight back against some of the most nefarious bacterial and viral infections, giving humanity a fighting chance. This fourth volume in the Medicinal Plants in the Asia Pacific for Zoonotic Pandemics series provides an unprecedented, comprehensive overview of the pharmacological activity of more than 100 medicinal plants used for the treatment of microbial infections in Asia and the Pacific. The text discusses the actions of such plants against viruses and bacteria representing a threat of epidemic and pandemic diseases, including COVID-19, with an emphasis on the molecular basis and cellular pathways. Scientific names, botanical classifications and descriptions, medicinal uses, and chemical constituents are presented, along with chemical structures and a vast selection of bibliographical references. FEATURES Introduces the molecular mechanism of natural products from medicinal plants in Asia on bacteria and viruses Includes phylogenetic presentations of a selection of medicinal plants and a chemotaxonomical rationale of antiviral and antibacterial actions Discusses the chemical structure–activity relationship, pharmacokinetics, and bioavailability of antimicrobial principles This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries looking forward to developing antiviral and antibacterial agents from medicinal plants in Asia. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics is a critical reference for anyone involved in the discovery of leads for the treatment of pandemic viral, bacterial, and infections. "This book will be an important resource for scientists, as well as people passionate about helping to save these critical resources. Perhaps a new drug lead will be identified from at least one of these plants." —From the Foreword by Dr. Mark S. Butler, MSBChem Consulting, Brisbane, Australia
Medicinal Plants in the Asia Pacific for Zoonotic Pandemics provides an unprecedented, comprehensive overview of the phylogeny, botany, ethnopharmacology, and pharmacology of more than 100 plants used in the traditional systems of Asia and Pacific medicine for the treatment of microbial infections. It discusses their actions and potentials against viruses, bacteria, and fungi that represent a threat of epidemic and pandemic diseases, with an emphasis on the molecular basis and cellular pathways. This book presents for each plant the scientific name, the botanical classification, traditional medicinal uses, active chemical constituents, and pharmacology. This volume is a critical reference for anyone involved in the discovery of leads for the development of lead molecules or phytopharmaceutical products for the prevention or treatment of pandemic viral, bacterial, or fungal infections. FEATURES Includes phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal actions Discusses chemical structure–activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi Contains a selection of botanical plates and useful bibliographic references This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics includes commentary sections that invite further research and reflection on the fascinating and timely subject of the development of leads or herbals from Asia-Pacific medicinal plants to safeguard humanity against the forthcoming waves of viral, bacterial, or fungal pandemics. This book is an ideal reference text for medicinal plant enthusiasts.