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First multi-year cumulation covers six years: 1965-70.
Based upon the popular review course from Harvard Medical School, The Brigham Intensive Review of Internal Medicine is a comprehensive study guide for the American Board of Internal Medicine certification or maintenance of certification examination as well as for general practice review by physicians and residents. This authoritative, thorough resource provides in-depth coverage on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Editors Ajay K. Singh and Joseph Loscalzo recruited leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital to contribute to this book. Featuring over 600 board review questions, with numerous tables and figures, chapters offer detailed discussions with emphasis on essential learning points. Over 100 chapters are organized into 10 broad sections, with one additional section dedicated to board simulation. As the required content for the American Board of Internal Medicine continues to evolve, studying can prove challenging. The Brigham Intensive Review of Internal Medicine is the ideal study guide for anyone preparing for certification or recertification.
Introducing an innovative, systematic approach to understanding differential diagnosis, Andre M. Mansoor's Frameworks for Internal Medicine, 2nd Edition, trains students and other learners to think like clinicians and master the methodology behind diagnosing the most commonly encountered conditions in internal medicine. Significantly updated and enhanced throughout, the 2nd Edition of this highly visual resource uses a case-based, Q&A-style format to build frameworks that guide learners through each step in the differential diagnosis process. These unique frameworks not only equip learners for success during internal medicine clerkships, rotations, and residencies, but also help ensure more confident differential diagnoses in clinical settings. NEW! 10 new chapters walk students through proven diagnostic approaches for increasingly common clinical problems encountered in internal medicine. NEW! Full-color design with updated images throughout keeps students engaged and clarifies clinical details. Unfolding frameworks approach simplifies the differential diagnosis process and teaches students to think like clinicians. Case-based, Q&A-style format reinforces retention and clinical reasoning. Additional Completed Frameworks available online provide point-of-care guidance for even more commonly encountered problems.
The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.
Following the organization of Dr. Marc Sabatine’s bestselling Pocket Medicine manual, Pocket Medicine High-Yield Board Review is an all-new, must-have study guide for advanced medical students; for residents in internal medicine, family medicine, and primary care; and for practitioners. This new review brings you authoritative, trusted content designed to prepare you for success on licensing, certification, and recertification exams and hone your knowledge of internal medicine.