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Membrane processes today play a signifi cant role in the replacement therapy for acute and chronic organ failure diseases. Current extracorporeal blood purifi cation and oxygenation devices employ membranes acting as selective barriers for the removal of endogeneous and exogeneous toxins and for gas exchange, respectively. Additionally, membrane technology offers new interesting opportunities for the design of bioartificial livers, pancreas, kidneys, lungs etc. This book reviews the latest developments in membrane systems for bioartificial organs and regenerative medicine, investigates how membrane technology can improve the quality and efficiency of biomedical devices, and highlights the design procedures for membrane materials covering the preparation, characterization, and sterilization steps as well as transport phenomena. The different strategies pursued for the development of membrane bioartifi cial organs, including crucial issues related to blood/cell-membrane interactions are described with the aim of opening new and exciting frontiers in the coming decades. The book is a valuable tool for tissue engineers, clinicians, biomaterials scientists, membranologists as well as biologists and biotechnologists. It is also a source of reference for students, academic and industrial researchers in the topic of biotechnology, biomedical engineering, materials science and medicine.
Controlled drug release systems : mechanisms and kinetics / M Sanopoulou and K G Papadokostaki -- Membranes for artificial kidney / J Vienken -- Advanced blood purification therapies / O de Beek, I Geremia, D Pavlenko and D Stamatialis -- Membranes for artificial lung and gas exchange applications / F Wiese -- Membranes for bioartificial kidney / N V Chevtchik, P Caetano-Pinto, R Masereeuw and D Stamatialis -- Membrane-based bioartificial liver devices / S Khakpour, H M M Ahmed and L De Bartolo -- Are co-culture approaches able to improve biological functions of membrane-based bioartificial livers? / V Pandolfi, U Pereira, M Dufresne and C Legallais -- Membranes for bioartificial pancreas / K Skryzpek, A van Apelddorn and D Stamatialis -- Health economic evaluation during the translation of medical technologies : involving users in the design of bio-artificial pancreas transplantation scenarios for type i diabetes / M IJzerman, T Wissing and E de Koning -- Membranes for regenerative medicine in clinical applications / G Falvo, D Labate and G Catapano -- Membranes for organs on chips / M P Tibbe, L I Segerink, A D van der Meer, D Stamatialis and A van den Berg
Comprehensive Membrane Science and Engineering, Second Edition, Four Volume Set is an interdisciplinary and innovative reference work on membrane science and technology. Written by leading researchers and industry professionals from a range of backgrounds, chapters elaborate on recent and future developments in the field of membrane science and explore how the field has advanced since the previous edition published in 2010. Chapters are written by academics and practitioners across a variety of fields, including chemistry, chemical engineering, material science, physics, biology and food science. Each volume covers a wide spectrum of applications and advanced technologies, such as new membrane materials (e.g. thermally rearranged polymers, polymers of intrinsic microporosity and new hydrophobic fluoropolymer) and processes (e.g. reverse electrodialysis, membrane contractors, membrane crystallization, membrane condenser, membrane dryers and membrane emulsifiers) that have only recently proved their full potential for industrial application. This work covers the latest advances in membrane science, linking fundamental research with real-life practical applications using specially selected case studies of medium and large-scale membrane operations to demonstrate successes and failures with a look to future developments in the field. Contains comprehensive, cutting-edge coverage, helping readers understand the latest theory Offers readers a variety of perspectives on how membrane science and engineering research can be best applied in practice across a range of industries Provides the theory behind the limits, advantages, future developments and failure expectations of local membrane operations in emerging countries
Current Trends and Future Developments on (Bio-) Membranes: Membrane Applications in Artificial Organs and Tissue Engineering reports on membrane applications in the field of biomedical engineering, ranging from artificial organs, to tissue engineering. The book offers a comprehensive review of all the current scientific developments and various applications of membranes in this area. It is a key reference text for R&D managers in industry who are interested in the development of artificial and bioartificial organs, as well as academic researchers and postgraduate students working in the wider area of artificial organs and tissue engineering. Describes numerous bioartificial organ configurations and their relationships to membranes Includes new innovations and solutions in the development of artificial organs with membrane components Describes various membrane fabrication techniques for tissue engineering
This book deals with organ failure and the way it can be managed artificially without requiring a transplant. Written by a mixture of European and US physicians and surgeons, each of the chapters compares the artificial organ to what is currently available from the transplant point of view to highlight the current and modern available techniques for organ replacement. The book will be a useful reading for postgraduate students and people interested in modern surgical and medical technology.
This book covers topics including the delivery of biologicals using synthetic polymers, cell encapsulation, and gene delivery. It deals with the use of synthetic polymers for the purpose of isolating biologicals by describing the use of stimulus-responsive polymers.
Comprehensive Biotechnology, Third Edition, Six Volume Set unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of biotechnology Provides in-depth treatment of relevant topics from recognized authorities, including the contributions of a Nobel laureate Presents the perspective of researchers in different fields, such as biochemistry, agriculture, engineering, biomedicine and environmental science
This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.
Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions