Download Free Matrix Metalloproteinases In Left Ventricular Remodeling Book in PDF and EPUB Free Download. You can read online Matrix Metalloproteinases In Left Ventricular Remodeling and write the review.

The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.
This volume provides new advances regarding the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs give new insights in the relationship between activation of inflammatory cells and tissue remodelling and advise new therapeutics possibilities to the treatment of inflammatory disease. The volume has an international authorship and is written by leading experts in the field.
Introduction: Matrix metalloproteinases (MMPs) are a family ofzinc dependant endopeptidases which selectively degrade components ofthe extracellular matrix. Degradation ofthis matrix is central to several aspects ofcardiovascular disease including adverse left ventricular remodelling, a process which is intimately linked to prognosis. The basis ofthis thesis was to investigate the role ofMMP's and their natural inhibitors tissue inhibitors ofmetalloproteinases (T!MP's) in the process of left ventricular remodelling, clinical heart failure and adverse prognosis post acute myocardial infarction (AMI). Methods: We recruited patients post AMI. Stage I aimed to examine the temporal profile of several MMP's and their relationship with markers ofLV function, volumes and remodelling in a limited population size (n=9I). Stage 2 investigated a more extensive population (n=404), concentrating on a limited number ofMMP's/TIMP's and included clinical follow up to identify subjects with adverse prognosis. All patients were recruited from the CCU units ofthe University Hospitals ofLeicester. All donated venous blood samples at 0-12hrs, 12-24hrs and at 24hr intervals post symptoms until discharge for measurement ofMMP/TIMP's and underwent echocardiographic studies during their index admission and at follow up. During stage 2 all subjects were additionally followed for the clinical endpoints ofdeath or heart failure. We also performed a retrospective analysis ofthe effects ofdiabetes and stress hyperglycaemia on metalloproteinase expression and LV dysfunction post MI. Results: We present convincing data to implicate the MMP system in both LV remodelling and adverse prognosis post AMI. Stage I demonstrates individual temporal profiles of MMP's and presents data on determinants ofMMP expression. We show an association between MMP-9 and LV dysfunction, volumes and remodelling post AMI. Stage 2 confirms both this data and observes similar results for TIMP-I. In addition we demonstrate the association between both MMP-9 and TIMP-I with adverse prognosis and compare with N terminal pro BNP as a prognostic marker. Our retrospective audit ofthe effects ofdiabetes and stress hyperglycaemia is a hypothesis generating chapter which presents association between post MI hyperglycaemia, elevated MMP's and adverse LV function. Summary: Altered MMP/TIMP expression occurs post AMI and is associated with LV dysfunction and remodelling, and with adverse prognosis. The MMP system may represent a potential therapeutic target post AMI.
Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling, Volume 147 contains up-to-date information on the biology and function of matrix metalloproteinases and how their effects on tissue remodeling are altered in diseases of the cardiovascular, pulmonary, and musculoskeletal systems and in other tissues and organs, and in cancer. This latest release covers such highly evolving topics as Biochemical and Biological Attributes of Matrix Metalloproteinases, Matrix Metalloproteinases in Myocardial Infarction and Heart Failure, The Balance Between Metalloproteinases and TIMPs: Critical Regulator of Microvascular Endothelial Cell Function in Health and Disease, and Matrix Metalloproteinases and Platelet Function. As part of the Progress in Molecular Biology and Translational Science, users will find contributions from prominent scientists and highly-recognized experts who have major accomplishments in the research field of matrix metalloproteinases. - Focuses on matrix metalloproteinases and their role in tissue remodeling under physiological and pathological conditions - Contains up-to-date information on matrix metalloproteinases that is clearly presented in a concise fashion with helpful illustrations and supporting references - Includes comprehensive reviews written by prominent scientists and highly-recognized experts in the field of matrix metalloproteinases and tissue remodeling
This study covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of identified MMPs.
This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
This careful revision keeps pace with developments in the field, with new chapters on PET Metabolism, CT and MRI in the Emergency Department, Image-Guided Electrophysiology Mapping and Ablation, and Identification of Vulnerable Atherosclerotic Plaque by Radionuclide and CT techniques, plus the introduction of new contributors Udo Hoffman and Stephan Achenbach. Praised in its previous edition as a concise source of essential information, this new edition presents the most recent information in an accessible format and serves as an excellent reference source for all cardiologists, radiologists and nuclear medicine physicians.