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Features a practical approach to the analysis of biomedical data via mathematical methods and provides a MATLAB® toolbox for the collection, visualization, and evaluation of experimental and real-life data Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® presents a practical approach to the task that biological scientists face when analyzing data. The primary focus is on the application of mathematical models and scientific computing methods to provide insight into the behavior of biological systems. The author draws upon his experience in academia, industry, and government–sponsored research as well as his expertise in MATLAB to produce a suite of computer programs with applications in epidemiology, machine learning, and biostatistics. These models are derived from real–world data and concerns. Among the topics included are the spread of infectious disease (HIV/AIDS) through a population, statistical pattern recognition methods to determine the presence of disease in a diagnostic sample, and the fundamentals of hypothesis testing. In addition, the author uses his professional experiences to present unique case studies whose analyses provide detailed insights into biological systems and the problems inherent in their examination. The book contains a well-developed and tested set of MATLAB functions that act as a general toolbox for practitioners of quantitative biology and biostatistics. This combination of MATLAB functions and practical tips amplifies the book’s technical merit and value to industry professionals. Through numerous examples and sample code blocks, the book provides readers with illustrations of MATLAB programming. Moreover, the associated toolbox permits readers to engage in the process of data analysis without needing to delve deeply into the mathematical theory. This gives an accessible view of the material for readers with varied backgrounds. As a result, the book provides a streamlined framework for the development of mathematical models, algorithms, and the corresponding computer code. In addition, the book features: Real–world computational procedures that can be readily applied to similar problems without the need for keen mathematical acumen Clear delineation of topics to accelerate access to data analysis Access to a book companion website containing the MATLAB toolbox created for this book, as well as a Solutions Manual with solutions to selected exercises Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® is an excellent textbook for students in mathematics, biostatistics, the life and social sciences, and quantitative, computational, and mathematical biology. This book is also an ideal reference for industrial scientists, biostatisticians, product development scientists, and practitioners who use mathematical models of biological systems in biomedical research, medical device development, and pharmaceutical submissions.
This book presents innovative intelligent techniques, with an emphasis on their biomedical applications. Although many medical doctors are willing to share their knowledge – e.g. by incorporating it in computer-based advisory systems that can benefit other doctors – this knowledge is often expressed using imprecise (fuzzy) words from natural language such as “small,” which are difficult for computers to process. Accordingly, we need fuzzy techniques to handle such words. It is also desirable to extract general recommendations from the records of medical doctors’ decisions – by using machine learning techniques such as neural networks. The book describes state-of-the-art fuzzy, neural, and other techniques, especially those that are now being used, or potentially could be used, in biomedical applications. Accordingly, it will benefit all researchers and students interested in the latest developments, as well as practitioners who want to learn about new techniques.
Mathematical modelling and computer simulations are playing a crucial role in the solution of the complex problems arising in the field of biomedical sciences and provide a support to clinical and experimental practices in an interdisciplinary framework. Indeed, the development of mathematical models and efficient numerical simulation tools is of key importance when dealing with such applications. Moreover, since the parameters in biomedical models have peculiar scientific interpretations and their values are often unknown, accurate estimation techniques need to be developed for parameter identification against the measured data of observed phenomena. In the light of the new challenges brought by the biomedical applications, computational mathematics paves the way for the validation of the mathematical models and the investigation of control problems. The volume hosts high-quality selected contributions containing original research results as well as comprehensive papers and survey articles including prospective discussion focusing on some topical biomedical problems. It is addressed, but not limited to: research institutes, academia, and pharmaceutical industries.
Medical imaging is an important and rapidly expanding area in medical science. Many of the methods employed are essentially digital, for example computerized tomography, and the subject has become increasingly influenced by develop ments in both mathematics and computer science. The mathematical problems have been the concern of a relatively small group of scientists, consisting mainly of applied mathematicians and theoretical physicists. Their efforts have led to workable algorithms for most imaging modalities. However, neither the fundamentals, nor the limitations and disadvantages of these algorithms are known to a sufficient degree to the physicists, engineers and physicians trying to implement these methods. It seems both timely and important to try to bridge this gap. This book summarizes the proceedings of a NATO Advanced Study Institute, on these topics, that was held in the mountains of Tuscany for two weeks in the late summer of 1986. At another (quite different) earlier meeting on medical imaging, the authors noted that each of the speakers had given, there, a long introduction in their general area, stated that they did not have time to discuss the details of the new work, but proceeded to show lots of clinical results, while excluding any mathematics associated with the area.
This book provides an accessible yet rigorous introduction to topology and homology focused on the simplicial space. It presents a compact pipeline from the foundations of topology to biomedical applications. It will be of interest to medical physicists, computer scientists, and engineers, as well as undergraduate and graduate students interested in this topic. Features: Presents a practical guide to algebraic topology as well as persistence homology Contains application examples in the field of biomedicine, including the analysis of histological images and point cloud data
Medical imaging and medical image analysisare rapidly developing. While m- ical imaging has already become a standard of modern medical care, medical image analysis is still mostly performed visually and qualitatively. The ev- increasing volume of acquired data makes it impossible to utilize them in full. Equally important, the visual approaches to medical image analysis are known to su?er from a lack of reproducibility. A signi?cant researche?ort is devoted to developing algorithms for processing the wealth of data available and extracting the relevant information in a computerized and quantitative fashion. Medical imaging and image analysis are interdisciplinary areas combining electrical, computer, and biomedical engineering; computer science; mathem- ics; physics; statistics; biology; medicine; and other ?elds. Medical imaging and computer vision, interestingly enough, have developed and continue developing somewhat independently. Nevertheless, bringing them together promises to b- e?t both of these ?elds. We were enthusiastic when the organizers of the 2004 European Conference on Computer Vision (ECCV) allowed us to organize a satellite workshop devoted to medical image analysis.
Up to the last decade or so, most general modeling approaches to the study of molecular components of biological responses have required significant amount of computer time, expertise, and resources, as well as highly specialized and often custom-written programs. With Biomedical Applications of Computer Modeling you don't have to be a computer sci
Over 900 references to monographic and journal literature about the use of computers in biology and medicine. Emphasis in the annotations is on computer applications, rather than on methods and results generally common to authors' abstracts. Entries arranged by topics under bibliographies, monographs, and articles. Author, subject indexes.