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Marketing of Clozaril

United States. Congress. Senate. Committee on the Judiciary. Subcommittee on Antitrust, Monopolies, and Business Rights

Published: 1991

Total Pages: 144


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Real-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. Clozapine also reduces rates of suicidality, psychiatric hospitalization and all-cause mortality. However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. In response to worldwide efforts to promote clozapine use, this user-friendly Handbook provides clinicians with evidence-based approaches for patient management, as well as logical approaches to the management of clinical situations and adverse effects. It outlines clearly the rationale for specific management decisions and prioritises the options based on this logic. This Handbook is designed for use by clinicians worldwide and is essential reading for all mental health care professionals.
Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.
These guidelines from NICE set out clear recommendations, based on the best available evidence, for health care professionals on how to work with and implement physical, psychological and service-level interventions for people with various mental health conditions.The book contains the full guidelines that cannot be obtained in print anywhere else. It brings together all of the evidence that led to the recommendations made, detailed explanations of the methodology behind their preparation, plus an overview of the condition covering detection, diagnosis and assessment, and the full range of treatment and care approaches. There is a worse prognosis for psychosis and schizophrenia when onset is in childhood or adolescence, and this new NICE guideline puts much-needed emphasis on early recognition and assessment of possible psychotic symptoms. For the one-third of children and young people who go on to experience severe impairment as a result of psychosis or schizophrenia the guideline also offers comprehensive advice from assessment and treatment of the first episode through to promoting recovery.This guideline reviews the evidence for recognition and management of psychosis and schizophrenia in children and young people across the care pathway, encompassing access to and delivery of services, experience of care, recognition and management of at-risk mental states, psychological and pharmacological interventions, and improving cognition and enhancing engagement with education and employment.
This first full account of the problems posed by deinstitutionalization of chronic schizophrenic patients reports on innovations in hospital treatment and community-based aftercare, housing and community residence programs, counseling for families of schizophrenic patients, and the available methods of psychiatric, psychosocial, and parmacologic therapy, including psychiatric outpatient services.
A concise review of current research into suicide providing a guide to understanding this disease and its increasing incidence globally.
"Discusses the chemical imbalance theory, pharmaceutical company ties with the FDA, deceptive designs of antidepressant drug studies, dangers of antidepressants, and how to avoid depression"--Publisher's description.
Clinical Psychopharmacology offers a comprehensive guide to clinical practice that explores two major aspects of the field: the clinical research that exists to guide clinical practice of psychopharmacology, and the application of that knowledge with attention to the individualized aspects of clinical practice. The text consists of 50 chapters, organized into 6 sections, focusing on disease-modifying effects, non-DSM diagnostic concepts, and essential facts about the most common drugs. This innovative book advocates a scientific and humanistic approach to practice and examines not only the benefits, but also the harms of drugs. Providing a solid foundation of knowledge and a great deal of practical information, this book is a valuable resource for practicing psychiatrists, psychiatric nurse practitioners, medical students and trainees in psychiatry, as well as pharmacists.
"With fine-tuned ethnographic sensibility, Jenkins explores the lived experience of psychosis, trauma, and depression among people of diverse cultural orientations, eloquently showing how mental illness engages fundamental human processes of self, desire, gender, identity, attachment, and meaning. Her studies illustrate the shaping of human reality and subjectivity in light of extreme psychological suffering, and shed light on psycho-political processes of alterity, precarity, and repression in the social rendering of the mentally ill as non-human or less than fully human. Extraordinary Conditions addresses the critical need to empathically engage the experience of persons living with conditions that are culturally defined as mental illness. Jenkins compellingly shows that mental illness is better characterized in terms of struggle than symptoms and that culture matters vitally in all aspects of mental illness from onset to recovery. Analysis at this edge of experience refashions the boundaries between ordinary and extraordinary, routine and extreme, healthy and pathological. The book argues that the study of mental illness is indispensable to anthropological understanding of culture and experience, and reciprocally that understanding culture and experience is critical to the study of mental illness. While anthropology neglects the extraordinary to its theoretical and empirical peril, psychiatry neglects culture to its theoretical and clinical peril"--Provided by publisher.