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The Oxford Textbook of Clinical Research Ethics is the first comprehensive and systematic reference on clinical research ethics. Under the editorship of experts from the U.S. National Institutes of Health of the United States, the book's 73 chapters offer a wide-ranging and systematic examination of all aspects of research with human beings. Considering the historical triumphs of research as well as its tragedies, the textbook provides a framework for analyzing the ethical aspects of research studies with human beings. Through both conceptual analysis and systematic reviews of empirical data, the contributors examine issues ranging from scientific validity, fair subject selection, risk benefit ratio, independent review, and informed consent to focused consideration of international research ethics, conflicts of interests, and other aspects of responsible conduct of research. The editors of The Oxford Textbook of Clinical Research Ethics offer a work that critically assesses and advances scholarship in the field of human subjects research. Comprehensive in scope and depth, this book will be a crucial resource for researchers in the medical sciences, as well as teachers and students.
An important historical account of Tuskegee University’s significant advances in health care, which affected millions of lives worldwide. Alabama’s celebrated, historically black Tuskegee University is most commonly associated with its founding president, Booker T. Washington, the scientific innovator George Washington Carver, or the renowned Tuskegee Airmen. Although the university’s accomplishments and devotion to social issues are well known, its work in medical research and health care has received little acknowledgment. Tuskegee has been fulfilling Washington’s vision of “healthy minds and bodies” since its inception in 1881. In To Raise Up the Man Farthest Down, Dana R. Chandler and Edith Powell document Tuskegee University’s medical and public health history with rich archival data and never-before-published photographs. Chandler and Powell especially highlight the important but largely unsung role that Tuskegee University researchers played in the eradication of polio, and they add new dimension and context to the fascinating story of the HeLa cell line that has been brought to the public’s attention by popular media. Tuskegee University was on the forefront in providing local farmers the benefits of agrarian research. The university helped create the massive Agricultural Extension System managed today by land grant universities throughout the United States. Tuskegee established the first baccalaureate nursing program in the state and was also home to Alabama’s first hospital for African Americans. Washington hired Alabama’s first female licensed physician as a resident physician at Tuskegee. Most notably, Tuskegee was the site of a remarkable development in American biochemistry history: its microbiology laboratory was the only one relied upon by the National Foundation for Infantile Paralysis (the organization known today as the March of Dimes) to produce the HeLa cell cultures employed in the national field trials for the Salk and Sabin polio vaccines. Chandler and Powell are also interested in correcting a long-held but false historical perception that Tuskegee University was the location for the shameful and infamous US Public Health Service study of untreated syphilis. Meticulously researched, this book is filled with previously undocumented information taken directly from the vast Tuskegee University archives. Readers will gain a new appreciation for how Tuskegee’s people and institutions have influenced community health, food science, and national medical life throughout the twentieth century.
Here David Oshinsky tells the gripping story of the polio terror and of the intense effort to find a cure, from the March of Dimes to the discovery of the Salk and Sabin vaccines--and beyond. Drawing on newly available papers of Jonas Salk, Albert Sabin and other key players, Oshinsky paints a suspenseful portrait of the race for the cure, weaving a dramatic tale centered on the furious rivalry between Salk and Sabin. He also tells the story of Isabel Morgan, perhaps the most talented of all polio researchers, who might have beaten Salk to the prize if she had not retired to raise a family. Oshinsky offers an insightful look at the National Foundation for Infantile Paralysis, which was founded in the 1930s by FDR and Basil O'Connor, it revolutionized fundraising and the perception of disease in America. Oshinsky also shows how the polio experience revolutionized the way in which the government licensed and tested new drugs before allowing them on the market, and the way in which the legal system dealt with manufacturers' liability for unsafe products. Finally, and perhaps most tellingly, Oshinsky reveals that polio was never the raging epidemic portrayed by the media, but in truth a relatively uncommon disease. But in baby-booming America--increasingly suburban, family-oriented, and hygiene-obsessed--the specter of polio, like the specter of the atomic bomb, soon became a cloud of terror over daily life. Both a gripping scientific suspense story and a provocative social and cultural history, Polio opens a fresh window onto postwar America.
Providing expert advice from established scholars in the field of political science, this engaging companion book to Teaching Undergraduate Political Methodology imparts informative guidance on teaching research methods across the graduate curriculum. Written in a concise yet comprehensive style, it illustrates practical and conceptual advice, alongside more detailed chapters focussing on the different aspects of teaching political methodology.