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"WHO has developed this manual in order to strengthen the laboratory diagnosis and virological surveillance of influenza infection by providing standard methods for the collection, detection, isolation and characterization of viruses."--Publisher's description.
In many settings influenza is recognized as a major cause of disease and death. In other parts of the world however its epidemiology and the degree of its impact on human health remain relatively uncertain - in large part due to a lack of virological and disease surveillance. WHO has developed this manual in order to strengthen the laboratory diagnosis and virological surveillance of influenza infection by providing standard methods for the collection detection isolation and characterization of viruses. The specific objectives of the manual include:. . increasing understanding of the principle.
The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: • Influenza Perspectives • Structure and Replication • Evolution and Ecology • Epidemiology and Surveillance • Immunology • Vaccines and Vaccine Development • Clinical Aspects and Antivirals • Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.
The World Health Organization (WHO) estimates that 3-5 million cases of severe influenza worldwide will result in 250,000-500,000 deaths annually. Collectively, data are shared via the WHO's Global Influenza Surveillance and Response System (GISRS), which includes 143 institutions in 113 WHO member states, to help alert the emergence of antigenic variants or the beginning of a pandemic. In April 2009, the Centers for Disease Control and Prevention (CDC) cited the first incidence of human-to-human transmission of pandemic H1N1, also referred to as swine influenza A, which was antigenically distinct from other circulating human H1N1. As the first influenza pandemic of the twenty-first century, pandemic H1N1 was not included in the annual trivalent vaccine regimen, leaving a large majority of the population unprotected from the newly emerging pathogen.
Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.
Influenza virus infections are a serious health problem. Each year, about 500 million people are infected by the virus, resulting in about 500,000 deaths worldwide. The occurrence of new influenza subtypes has caused severe pandemics, including the 2009 swine flu (vH1N1). In addition, highly pathogenic viruses, like subtypes H7N7 and H5N1, also called the fowl plague and bird flu, respectively, represent enormous economic threats to livestock farming. This book begins with descriptions of the molecular make-up of influenza viruses, their replication cycles and functions of viral proteins. A history of major influenza pandemics is provided as is a detailed article discussing how viral growth and decay is mathematically modeled to evaluate the biological parameters governing interaction between host and virus. Several laboratory protocols describe how influenza virus is handled and used in animal models to study host-pathogen interactions and test potential new therapies. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of influenza research for students or interdisciplinary collaborators.
This guidance is an update of WHO global influenza preparedness plan: the role of WHO and recommendations for national measures before and during pandemics, published March 2005 (WHO/CDS/CSR/GIP/2005.5).
The successful prophylaxis and treatment of ubiquitous respiratory infections is essential for the enhancement of public health. The chapters provide new insights into the biology of causative pathogens, tackle the epidemiological aspects, and present an update on diagnostics, prevention and therapy of infections. The emerging new pathogens and antibiotic resistance of the old ones are discussed. Novel markers of the severity of community acquired pneumonia, which bears high morbidity and mortality, also are presented.
Technical report of the fourth meeting of the WHO Strategic Advisory Group of Experts on In Vitro Diagnostics, 2022 (including the fourth WHO model list of essential in vitro diagnostics (EDL 4)). This report also includes the applications received for the EDL 4 and a summary of the deliberations and recommendations by the SAGE IVD members and the methodologist that assessed the supportive evidence for the EDL 4 applications.