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"Provides the latest research results and suggests new topics for interdisciplinary study of metal ions, catalysis, and biochemical systems. Second Edition highlights potential applications; includes new chapters on zinc and FeS clusters; presents new X-ray analysis of metalloenzymes; and more."
Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.
This collection of comprehensive reviews describes the present knowledge of the enzyme mechanisms involved in the biodegradation of wood and wood components, cellulose, hemicelluloses and lignin by both fungi and bacteria. The extensive knowledge, presented in this volume, was developed in laboratories world-wide over the last few decades and constitutes the foundation for present and future biotechnology in the pulp and paper industry.
Manganese in Metabolism and Enzyme Function provides an understanding of the various biological roles of the trace levels of manganese found in mammalian systems. This text discusses the nutritional aspects of manganese in mammals. This book is organized into three sections encompassing 19 chapters. Section I discusses the effects of manganese deficiency, including abnormal pancreatic action and reduced pancreatic manganese in humans and laboratory animals. This text considers the criteria for adding manganese to infant formulas that are commercially available. Section II explores the effects of Mn(II) in protein kinases, protein phosphatases, and other enzymes. The reader is introduced to the electron paramagnetic resonance spectroscopic probes of manganese function. Other chapters discuss the extrinsic tag technique used to study the bioavailability of trace elements, such as iron and zinc. Finally, Section III examines the biophysical, biochemical, and physiological properties and uses of manganese. Nutritionists, toxicologists, scientists, and researchers will find this book extremely useful.
Bioinorganic chemistry is primarily concerned with the role of metal atoms in biology and is a very active research field. However, even though such important structures of metalloenzymes are known, as the MoFeCo of nitrogenase, Cu or Mn superoxide dismutase and plastocyanin, the synthetic routes to the modelling of such centers remains a matter of acute scientific interest. Other metalloenzymes, such as the Mn center of the oxygen evolving complex of PSII, are still the focus of in-depth examination, both spectroscopic and structural. Another area of concern is the interaction between drugs and metals and metal ion antagonism. Understanding the chemistry of metal ions in biological systems will bring benefits in terms of understanding such problems as biomineralization and the production of advanced materials by micro-organisms. The 29 contributions to Bioinorganic Chemistry: An Inorganic Perspective of Life give an excellent summary of the state of the art in this field, covering areas from the NMR of paramagnetic molecules to the use of lanthanide porphyrins in artificial batteries.
Manganese in Health and Disease discusses recent advances of the role of manganese on different human pathologies. The book presents research discussing the possible role of manganese in the development of some degenerative diseases such as diabetes, osteoporosis, and atherosclerosis. The role of manganese in individuals with epilepsy and congenital malformations is also discussed. This comprehensive book will interest basic researchers and clinicians including research scientists, physicians, nutritionists, dietitians, nurses, and educators.
This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and most notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine.
This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.