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This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book. A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject. Chapter 9 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
This volume of the established Subcellular Biochemistry series presents 20 chapters dealing with a broad range of interesting protein complexes. It will enable researchers to readily appreciate the major contribution from both X-ray crystallography and cryo-electron microscopy in this field of study. The biological significance of these structural studies is emphasised throughout the book. The diversity of the material included here indicates the breadth of this field and the tremendous progress that has been made in recent years. The book is directed primarily to advanced students and researchers in structural biology, and others in the biochemical sciences. It will be supplemented by other related books within the Subcellular Biochemistry series. One of the Editors (JM-W) is actively involved in structural biology and the other (JRH), as a retired academic and the Series Editor of Subcellular Biochemistry, has long experience at editing multi-author books./div
This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established. The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes. Significant topics present here are: Fatty Acid Synthase, the Fork Protection Complex, Ribonucleotide Reductase, the Kinetochore, G proteins, the FtsEX Complex, the Kainate Receptor, the Photosystem I-antenna, the Mycobacterial Arabinofuranosyltransferases, the the Bacterial Flagellum, the Actomyosin Complex, Motile Cilia, SLS Collagen Polymorphic Structures, and the Reovirus Capsid and Polymerase. Up-dates/expansion of chapter topics present in earlier volumes are now included in chapters here, e.g., those on Ferritin-like proteins and the Multi-tRNA Synthetase. The book is richly illustrated throughout, the result of an impressive integration of structural data from X-ray crystallography and cryo-electron microscopy. The functional aspects of protein-protein interactions are also given a high priority.
This new volume explores the foundation of macromolecular science along with the field’s current challenges and solutions to challenges. The book discusses many new applications that have emerged recently based on different polymers and their composites, inlcuding some on the application of polymer composite in electromagnetic interference (EMI) shielding, sensing, and wound healing. This book discusses innovations in the synthesis and characterization of many different classes of polymers and provides in-depth explanations of the behavior of polymers in solutions and in bulk. It considers the synthesis, characterization properties, and applications of many polymer composites and nanomaterials. The diverse topics cover zein-based composites, nanocellulose extracted as a potential filler for polymers, polymers to strengthen concrete, polymer/metal nanocomposite magnetic materials, synthetic polymers in aquatic environments, pharmaceutical 3D-printing, alginate-based wound healing dressings, and more. Many chapters in the volume place emphasis on sustainable development and green eco-friendly approaches. This volume will help researchers to understand the significance of macromolecular science and research advances for sustainable development for the benefit of humanity. It emphasizes the many roles of macromolecular science in the important fields of science, such as chemistry, physics, engineering, biology, pharmaceutical science, and more.
The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient problems. Stay current with the latest molecular and technical advances as well as new treatment options implemented over the last few years. Use the latest technologies and devices to accurately diagnose and manage heart rhythm disorders. Consult new and expanded coverage of regenerative therapies, echo-guided procedures, cardiac pacing, and CRT, as well as a new section on pediatric electrophysiology and imaging. Enjoy improved visual guidance with many new full-color images. Log on to www.expertconsult.com to easily search the complete contents online and access a downloadable image library.
Volume 81 of Advances in Immunology contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries. - Edited by a new editor, Frederick W. Alt - Covers molecular mechanisms of host-pathogen interaction - Discusses prions and the immune system
Zusammenfassung: This edited volume discusses the identification, discovery, characterization, structure determination and modeling of multicomponent macromolecular complexes, and as such, it fully complements the first volume (ISBN 978-3-319-27214-6), which targeted methods of recombinant production of protein complexes. This book is divided in 8 sections offering a selection of technologies widely used in the characterization of protein and protein-nucleic acid complexes for different purposes and at different scales. From native electrophoresis methods, that are accessible to any reasonably well-equipped laboratory, to the sophisticated setup required for structure determination by cryo-electron microscopy or X-ray crystallography, this book contains a wide variety of clearly explained analytic and preparative approaches, connected with the production techniques developed on the previous volume. The readers will find an integral connection between this book and the first volume, which ensures a comprehensive and updated discussion of the main topics of the discipline. Taken together, these volumes constitute a cohesive and authoritative source of the research on multicomponent macromolecular complexes. In here, we focus on characterization of protein complexes in the broadest sense, which is not typically covered in other sources. Moreover, all chapters are carefully written by world renowned scientists and active researchers, making this volume ideal, not only as a reference source, but also as a companion book for the daily laboratory work. This book is aimed for a wide range of scientists, from science students to experienced researchers, working on protein and protein-nucleic acid complexes, who need a thorough understanding of protein production and complex characterization.