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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
Enth.: First maturation division of the Macaque ovum / Carl G. Hartman and George W. Corner ... etc.
Erythrocytes of the Rhesus and Cynomolgus Monkeys addresses the morphologic, quantitative, and generative aspects of the erythrocytes of the rhesus monkey Macaca mulatta and the cynomolgus monkey Macaca fascicularis (long-tailed macaque, crab-eating monkey). These two species are the most commonly selected nonhuman primates for basic science and cl
This volume presents a broad spectrum of research on the Cayo Santiago macaques, a unique free-ranging colony of rhesus macaques in Puerto Rico. It includes thirteen scientific studies on the behavior and biology of the Cayo Santiago macaques, as well as a detailed history of the colony and a complete bibliography of over 260 scientific publications based on work at Cayo Santiago from 1938 through 1984. The chapters represent examples of both short- and long-term research conducted on the island over the past several years. Some are reviews, providing a synopsis of complex longitudinal studies of behavior, vocal communication, functional morphology, genetics, and population dynamics. Others document the results of opportunistic studies of behavior or biological surveys. The chapters cover a broad range of topics, but all share a common dependence on the detailed life history and genealogical data which make the Cayo Santiago macaque colony an important international research resource.
Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the animals have roles in food security, agriculture, or as companion, wild, or working animals, the lessons we learn impact on many areas of the profession. This book highlights research ranging from the cardiovascular and musculoskeletal systems, prostate and hoof, through to histopathology, imaging, and molecular techniques. It investigates both healthy and pathological conditions at differing stages of life. The importance of each cell and tissue through to the whole organism is explored alongside the methodologies used to understand these vital structures and functions.
Long-tailed macaques (Macaca fascicularis) have a wide geographical distribution and extensively overlap with human societies across southeast Asia, regularly utilizing the edges of secondary forest and inhabiting numerous anthropogenic environments, including temple grounds, cities and farmlands. Yet despite their apparent ubiquity across the region, there are striking gaps in our understanding of long-tailed macaque population ecology. This timely volume, a key resource for primatologists, anthropologists and conservationists, underlines the urgent need for comprehensive population studies on common macaques. Providing the first detailed look at research on this underexplored species, it unveils what is currently known about the population of M. fascicularis, explores the contexts and consequences of human-macaque sympatry and discusses the innovative programs being initiated to resolve human-macaque conflict across Asia. Spread throughout the book are boxed case studies that supplement the chapters and give a valuable insight into specific field studies on wild M. fascicularis populations.
The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. - Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research - Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information - Includes four color images throughout
Animal and human societies are multifaceted. In order to understand how they have evolved, it is necessary to investigate each of the constituent facets including individual abilities and personalities, life-history traits, mating systems, demographic dynamics, gene flows, social relationships, ecology and phylogeny. By exploring the nature and evolution of macaque social organization, this book develops our knowledge of the rise of societies and their transformation during the course of evolution. Macaques are the most comprehensively studied of all monkey groups, and the 20 known species feature a broad diversity in their social relationships, making them a particularly good group for exploring the evolution of societies. This book will be of primary interest to those studying animal behaviour and primatology, but will also be useful to those involved in the study of human societies.
This 1996 book is a synthesis of the ecology, evolution, behaviour and conservation of extant macaque species.
A 1985 amendment to the Animal Welfare Act requires those who keep nonhuman primates to develop and follow appropriate plans for promoting the animals' psychological well-being. The amendment, however, provides few specifics. The Psychological Well-Being of Nonhuman Primates recommends practical approaches to meeting those requirements. It focuses on what is known about the psychological needs of primates and makes suggestions for assessing and promoting their well-being. This volume examines the elements of an effective care programâ€"social companionship, opportunities for species-typical activity, housing and sanitation, and daily care routinesâ€"and provides a helpful checklist for designing a plan for promoting psychological well-being. The book provides a wealth of specific and useful information about the psychological attributes and needs of the most widely used and exhibited nonhuman primates. Readable and well-organized, it will be welcomed by animal care and use committees, facilities administrators, enforcement inspectors, animal advocates, researchers, veterinarians, and caretakers.