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Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections. - Discusses ethical and safety aspects in an introductory background section - Covers principles of animal care and current techniques appropriate for the use of animal models of infection - Details a wide range of animals including rodents, rabbits, cats, and primates - Provides hands-on descriptions of how to set up the model - Discusses the major advantages and limitations of each model - Ensures full coverage of bacterial, fungal, viral, and parasitic infections
Because Delaware corporate law has virtually become national corporate law, its statutes and cutting-edge case law regarding corporations and alternative business entities have attracted practitioners nationwide to look to Delaware as the place of formation for corporations and other business entities. The definitive section-by-section guide to the country's most important corporate law, the Sixth Edition of Folk on the Delaware General Corporation Law is the place to turn for accurate, up-to-date, authoritative coverage of the Delaware statute. Its uniquely logical code section organization with penetrating and extensively annotated commentary brings you the best in: Effective strategies and options for specific business decisions and activities under the statute Detailed analysis of each key statutory provision and judicial decision Coverage of all the major cases, many of them unreported and unavailable in any other source Analysis organized by code section, with incisive and extensively annotated commentary Because it is a widely accepted authority in the field, Folk on the Delaware General Corporation Law is regularly cited by courts in states other than Delaware. Its section-by-section coverage makes it easy to quickly find the complete law text and analysis, including astute commentary on recent legislation and the most significant cases (including unreported opinions) with special attention to the more complex areas of practical concern.
The information compiled in this volume will be of use to everyone working on problems of inflammation. Clinicians will find the current state of scientific knowledge on the inflammatory response as induced via CD14 presented in a readable form, while the clinical aspects discussed will be of particular interest to scientists and students who lack a medical background.
This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.
Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.
In answer to public concerns, Microbial Food Safety in Animal Agriculture: Current Topics provides timely information on this area of increasing importance, giving a broad overview of pre-harvest microbial food safety. Written by specialists from around the world, this essential reference focuses on research in the areas of antimicrobial resistance, risk assessment, microbial detection methods and diagnostics, and emerging diseases. Coverage provides balanced overviews of Federal, industry, and academic perspectives on key issues in food safety. Specific organisms explored in depth include: Salmonellaspp., Campylobacterspp., Escherichia coli 0157:H7, and Listeria monocytogene. No other single source offers current information and detailed references on issues in pre-harvest food safety in production animal agriculture. Veterinarians, researchers, and food safety professionals in academia, government agencies, and food animal production industries will discover this resource crucial to defensive awareness.
In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
The second edition of this highly acclaimed text has been extensively revised and greatly expanded to reflect the considerable advances made in our understanding of the mechanisms of asthma and rhinitis. Containing the contributions of 242 experts of international standing, presented in 133 chapters, Asthma and Rhinitis provides an up-to-date, authoritative reference for both the clinician and scientist. The global approach given in this book mirrors the universal approach to the understanding of allergic disease. The editors have carried out a thorough and radical revision of the content by adding 6 new sections and 44 new chapters. Most of this expansion is due to greatly increased coverage of the clinical aspects of asthma, with new sections on childhood asthma and on drug treatment (each drug class has its own chapter). Also, the expansion of research into the genetic basis of asthma has necessitated a whole new section on Genetics, comprising some six chapters. There are also new chapters on adult-onset asthma and the relationship of asthma to sinusitis. A new section on Asthma in Special Circumstances includes chapters on asthma in pregnancy, asthma and surgery, asthma in the elderly and asthma in the context of critical care. In bringing the Second Edition fully up to date, the book has inevitably increased in size, and is now presented in two volumes. The second edition of Asthma and Rhinitis will continue the tradition of its predecessor of providing an up-to-the-minute reference for all those involved in the management of, and research into, asthma and rhinitis.