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Occupational epidemiology has emerged as a distinct subdiscipline of epidemiology and occupational medicine, addressing fundamental public health and scientific questions relating to the specification of exposure-response relationships, assessment of the adequacy of occupational exposure guidelines, and extrapolation of hazardous effects to other settings. This book reviews the wide range of principles and methods used in epidemiologic studies of working populations. It describes the historical development of occupational epidemiology, the approaches to characterizing workplace exposures, and the methods for designing and implementing epidemiologic studies. The relative strengths and limitations of different study designs are emphasized. Also included are more advanced discussions of statistical analysis, the estimation of doses to biological targets, and applications of the data derived from occupational epidemiology studies to disease modeling and risk assessment. The volume will serve both as a textbook in epidemiology and occupational medicine courses and as a practical handbook for the design, implementation, and interpretation of research in this field.
This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field. The topics include: exposure to and biomonitoring of PAHs in the human population; metabolic activation of PAHs; genotoxicity and repair of PAH-induced DNA damage; and factors modulating individual susceptibility to the deleterious effects of PAHs.
While there are hundreds of books available on many different aspects of asbestos, none contain the encyclopedic, comprehensive coverage you will find here. Edited by leading authorities, with contributions from specialists and leaders in their respective fields, Asbestos: Risk Assessment, Epidemiology, and Health Effects provides a cross-disciplin