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The incidence of allergies is increasing worldwide. Beside the well-established symptomatic treatments and subcutaneous immunotherapies, formerly known as de- or hyposensitization, a new form of treatment, local immunotherapy, has been developed in recent years. Local immunotherapy, though still controversially discussed, promises to be a curative, noninvasive, and easily applicable treatment for allergies. This volume summarizes the most current information on local immunotherapy compiled by internationally renowned specialists. In the methodology section, general aspects of local immunotherapy are presented including its history, allergen resorption and biodistribution, mechanisms of oral tolerance and practical experiences. The second section devoted to efficacy and safety presents findings from international placebo-controlled studies on nasal and sublingual immunotherapies with different allergens and for different allergic conditions including asthma and eczema. Possible side effects are also discussed. The concluding chapter critically evaluates the future prospects of this new method, pointing out still unresolved issues such as the exact immunological mechanisms, its long-term effects, or the standardization of dose and application intervals/duration. This state-of-the-art account will be of particular interest to scientists working in the field of allergy, clinical allergologists, pharmacists, and representatives from the pharmaceutical industry.
This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna Nowak-Wegrzyn, is devoted to Immunotherapy for Aeroallergens, Foods, and Venoms. Articles in this issue include: Mechanism of Immunotherapy: Focus SCIT and SLIT; Subcutaneous Immunotherapy Safety: Incidence per surveys and risk factors; Sublingual Immunotherapy for Other Indications: Venom large local, latex, atopic dermatitis and food; Questions and Controversies regarding venom immunotherapy; Socioeconomics or Comparative Effectiveness of Immunotherapy; Risk Reduction in Peanut Immunotherapy; Food OIT with Adjuvants; Peanut OIT: State of the art; Evolution of Immune Responses in Food Immunotherapy; Safety of Food Oral Immunotherapy: What we know and what we need to learn; Novel Vaccines for Food Allergy; IgG and IgE in Food Allergy - What's the connection?; and Sublingual and Patch Immunotherapy for Food Allergy.
This massive reference thoroughly analyzes the mechanisms implicated in the pathophysiology of asthma, such as T helper lymphocyte subsets, and the consequences of various extrinsic and intrinsic factors, and IgE receptor expression-reviewing current concepts in immunotherapeutic approaches for the treatment of this and other allergic diseases. Investigates the only category of treatment showing the potential to affect the natural course of allergic diseases and prevent the onset of asthma. Written by more than 80 internationally renowned pulmonary experts, allergic disease specialists, and basic researchers, Immunotherapy in Asthma discusses the efficacy of new medications examines the role of metachromatic cells, lymphocytes, macrophages, and other cell types present in bronchial biopsies presents basic topics such as the functional and phenotypic properties of Th1 and Th2 cells and their role in allergic disease and the regulation of IgE-mediated inflammatory responses addresses the deleterious effects of smoking and passive exposure to cigarette smoke in children and adults assesses differences and similarities between intrinsic and antigen-induced asthma describes the effects of immunogenic peptides on the cytokine production profile of allergen-specific CD4+ T cells explains the different clinical aspects of allergic responses, such as bronchial hyperreactivity and eosinophilic inflammation of the airways reviews the genetic basis of allergy, as well as risk factors for asthma explores oral, sublingual, local nasal, and local bronchial routes for noninjective immunotherapies evaluates various agents with modulatory effects on normal and pathogenic immune responses focuses on strategies for the prevention of childhood asthma and more! Containing over 3000 references, drawings, and tables, Immunotherapy in Asthma is an indispensable resource for pulmonologists, immunologists, allergists, and medical school students in these disciplines.
This massive reference thoroughly analyzes the mechanisms implicated in the pathophysiology of asthma, such as T helper lymphocyte subsets, and the consequences of various extrinsic and intrinsic factors, and IgE receptor expression-reviewing current concepts in immunotherapeutic approaches for the treatment of this and other allergic diseases. Investigates the only category of treatment showing the potential to affect the natural course of allergic diseases and prevent the onset of asthma. Written by more than 80 internationally renowned pulmonary experts, allergic disease specialists, and basic researchers, Immunotherapy in Asthma discusses the efficacy of new medications examines the role of metachromatic cells, lymphocytes, macrophages, and other cell types present in bronchial biopsies presents basic topics such as the functional and phenotypic properties of Th1 and Th2 cells and their role in allergic disease and the regulation of IgE-mediated inflammatory responses addresses the deleterious effects of smoking and passive exposure to cigarette smoke in children and adults assesses differences and similarities between intrinsic and antigen-induced asthma describes the effects of immunogenic peptides on the cytokine production profile of allergen-specific CD4+ T cells explains the different clinical aspects of allergic responses, such as bronchial hyperreactivity and eosinophilic inflammation of the airways reviews the genetic basis of allergy, as well as risk factors for asthma explores oral, sublingual, local nasal, and local bronchial routes for noninjective immunotherapies evaluates various agents with modulatory effects on normal and pathogenic immune responses focuses on strategies for the prevention of childhood asthma and more! Containing over 3000 references, drawings, and tables, Immunotherapy in Asthma is an indispensable resource for pulmonologists, immunologists, allergists, and medical school students in these disciplines.
This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna Nowak-Wegrzyn, is devoted to Immunotherapy for Aeroallergens, Foods, and Venoms. Articles in this issue include: Mechanism of Immunotherapy: Focus SCIT and SLIT; Subcutaneous Immunotherapy Safety: Incidence per surveys and risk factors; Sublingual Immunotherapy for Other Indications: Venom large local, latex, atopic dermatitis and food; Questions and Controversies regarding venom immunotherapy; Socioeconomics or Comparative Effectiveness of Immunotherapy; Risk Reduction in Peanut Immunotherapy; Food OIT with Adjuvants; Peanut OIT: State of the art; Evolution of Immune Responses in Food Immunotherapy; Safety of Food Oral Immunotherapy: What we know and what we need to learn; Novel Vaccines for Food Allergy; IgG and IgE in Food Allergy - What's the connection?; and Sublingual and Patch Immunotherapy for Food Allergy.
This fifth edition of the bestselling Allergens and Allergen Immunotherapy is now completely updated and revised to include subcutaneous, sublingual, and oral immunomodulator treatments of allergic disease.The redesigned book continues to provide comprehensive coverage of all types of allergens and allergen vaccines, giving clinicians the essential
The sixth edition of Lockey and Ledford's Allergens and Allergen Immunotherapy continues to provide comprehensive coverage of all types of allergens and allergen vaccines, providing clinicians the essential information they need to accurately diagnose and manage all allergic conditions. With new and updated chapters, the sixth edition is the most up-to-date, single resource on allergy and immunotherapy. Key Features Completely revised and updated Detailed single source reference on allergy and immunotherapy Reorganized to provide clinicians with essential information to make diagnoses and offer the best treatments
Revised and updated for its Seventh Edition, this highly acclaimed volume is a complete, current, and practical guide to the diagnosis and treatment of allergic disorders. This comprehensive yet concise reference will remain the first choice for residents and practitioners who need guidance to identify an allergy, confirm a diagnosis, or find effective therapies. It will also be an excellent aid for board review. This edition includes discussions of clinical trials in asthma and significant updates on drug allergy, imaging, occupational allergy, and immune deficiency evaluation. A Companion Website will include the fully searchable text and additional illustrations and tables.