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The second edition of this book on lipids, lipoprotein and membrane biochemistry has two major objectives - to provide anadvanced textbook for students in these areas of biochemistry,and to summarise the field for scientists pursuing research inthese and related fields. Since the first edition of this book was published in 1985 theemphasis on research in the area of lipid and membrane biochemistry has evolved in new directions. Consequently, thesecond edition has been modified to include four chapters on lipoproteins. Moreover, the other chapters have been extensivelyupdated and revised so that additional material covering the areas of cell signalling by lipids, the assembly of lipids andproteins into membranes, and the increasing use of molecular biological techniques for research in the areas of lipid, lipoprotein and membrane biochemistry have been included. Each chapter of the textbook is written by an expert in the field, but the chapters are not simply reviews of current literature. Rather, they are written as current, readable summaries of these areas of research which should be readily understandable to students and researchers who have a basic knowledge of general biochemistry. The authors were selected fortheir abilities both as researchers and as communicators. In addition, the editors have carefully coordinated the chapters sothat there is little overlap, yet extensive cross-referencing among chapters.
Fundamental knowledge of microbial lipids has advanced greatly during the last twenty years, and the microbiological and biochemical communities have long awaited a comprehensive source of reference. Microbial Lipids, Volume 2, is the second part of a two-volume work which will be the standard reference text for the next decade. With detailed contributions by leading experts, this authoritative and unique book covers the fullest possible range of lipid classes and microorganisms, including excellent sections on the occurrence and function of lipids and the biotechnology of lipids. Bringing the reader up-to-date with current knowledge, this book will be indispensable to any scientist and researcher interested in microbial lipids.
This short text is designed to provide basic information about plant and microbial lipids not only for scientists working in the microbiological and plant fields, but for anyone wanting a concise introduction to this aspect of lipid biochemistry. We have long been aware that standard biochemistry books tend to. concentrate (sometimes exclusively) on animal lipids, thus neglecting many of the important and special features of other organisms. It is not our intention that the book should be comprehensive and we have not, for instance, provided complete lists of lipid compositions of all plants and bacterial species; a number of excellent specialist texts exist and many of these are listed for further reading. Instead we have sought to provide sufficient information for an advanced undergraduate or a research student to give them a 'feel' for the subject. By a combination of generalisation and the use of examples of special interest we hope the book will whet the appetite of the reader so that, by their own research, they are stimulated to discover and, perhaps, answer some of the fascinating questions concerning plant and microbial lipids. We trust that we shall succeed in these aims, even if that will mean more competition for research funds in our own fields! J. L. HARWOOD N. J. RUSSELL November 1983 Acknowledgements Our research careers have been devoted to a study of lipids: we have no regrets and are happy to acknowledge Professors J. N.
The emerging field of lipidomics has been made possible because of advances in mass spectrometry, and in particular tandem mass spectrometry of lipid ions generated by electrospray ionization. The ability to carry out basic biochemical studies of lipids using electrospray ionization is predicated upon understanding the behaviour of lipid derived ions following collision induced decomposition and mechanisms of product ion formation. During the past 20 years, a wealth of information has been generated about lipid molecules that are now analysed by mass spectrometry, however there is no central source where one can obtain basic information about how these very diverse biomolecules behave following collisional activation. This book brings together, in one volume, this information so that investigators considering using tandem mass spectrometry to structurally characterize lipids or to quantitate their occurrence in a biological matrix, will have a convenient source to review mechanism of decomposition reactions related to the diversity of lipid structures. A separate chapter is devoted to each of seven major lipid classes including fatty acids, eicosanoids and bioactive lipid mediators, fatty acyl esters and amides, glycerol esters, glycerophospholipids, sphingolipids, and steroids. Mechanistic details are provided for understanding the pathways of formation of major product ions and ions used for structural characterization. In most cases specific ancillary information has been critical to understand the pathways, including isotope labeling and high resolution analysis of precursor and product ions. For a few specific examples such data is missing and pathways are proposed as a means to initiate further mass spectral experiments to prove or disprove pathway hypotheses. While this work largely centres on the lipid biochemistry of animal (mammalian) systems, general principles can be taken from the specific examples and applied to lipid biochemistry found in plants, fungi, prokaryotes and archeal organisms.
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.
This monograph will put the biogenic marine lipids of many organisms in perspective. Volume 1 of 2.