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This volume records the proceedings of a Limbic System Sympos ium held at the University of Toronto, November 5-6th, 1976 as a satellite event to the Sixth Annual Meeting of the Society of Neuroscience. The Symposium was designed in part as a tribute to James Papez on the 40th anniversary of the publication of his epochal paper "A Proposed Mechanism of Emotion". Papers by MacLean, Yakovlev, and Angevine provide personal recollections of Papez and an assessment of the significant contri bution he made to breaking down the still formidable barriers that separate our concepts of brain, mind, emotion, and behavior. Against this background subsequent speakers presented new information that further illuminates the anatomical, physiological and biochemical mechanisms underlying limbic system function. Viewed in juxtaposition this new information from "disparate" fields of neuroscience provides an increasingly coherent picture of the neuronal organization subserving a dynamic limbic system that we can now begin to visualize in operational and transactional terms. The final section of the symposium focusses on the recently identified "kindling" phenomenon which is viewed as a general model of neural plasticity and more particularly as a model of experi mentally induced limbic system dysfunction. Using this model it is possible to display, analyse, and experimentally manipulate long lasting changes in limbic system activity, which develop over ex tended periods of time and are expressed in a variety of behavioral end points involving learning and memory, seizure activity, and changes in emotionality and behavior.
107 with treatments that affect the arousal of the animals is also implied on the basis of the behavioral changes induced in the lesioned animals by amphetamine administration and by changes in the motivational circumstances under which the animals are tested. Studies of the effects of cingulate lesions in the rat have involved the production of midline cortical damage. Unfortunately, as reported in the previous chapter, the midline cortex of the rat is not comparable to the midline cortex of other animals as defined on the basis of the fibers it receives from the thalamus. In addition, lesions of the midline cortex, whether in the rat or in other species, are likely to interfere with fibers of the neural systems in or near it. These include the cingulum bundle and the supracallosal fibers of the fornix. Norepi nephrine-containing fibers also pass through this region in or near the cingulum bundle. These fibers ascend through the anterior dor solateral septal area and turn up and back to pass through the midline regions and innervate the entire medial cortex (Morrison, Molliver, & Grzanna, 1979). Lesions in this area reduce the norepinephrine distribution throughout the rostrocaudal extent of the medial cortex. A similar problem results from destruction to the anterior cortical regions. Lesions in that region could reduce the norepinephrine sup plies of the entire dorsolateral cortex.
The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Revisiting the Classic Studies is a series of texts that introduces readers to the studies in psychology that changed the way we think about core topics in the discipline today. It provokes students to ask more interesting and challenging questions about the field by encouraging a deeper level of engagement both with the details of the studies themselves and with the nature of their contribution. Edited by leading scholars in their field and written by researchers at the cutting edge of these developments, the chapters in each text provide details of the original works and their theoretical and empirical impact, and then discuss the ways in which thinking and research has advanced in the years since the studies were conducted. Brain and Behaviour: Revisiting the Classic Studies traces 17 ground-breaking studies by researchers such as Gage, Luria, Sperry, and Tulving to re-examine and reflect on their findings and engage in a lively discussion of the subsequent work that they have inspired. Suitable for students on neuropsychology courses at all levels, as well as anyone with an enquiring mind.
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
New edition building on the success of previous one. Retains core aim of providing an accessible introduction to behavioral neuroanatomy.
This original and lucid account of the complexities of love and its essential role in human well-being draws on the latest scientific research. Three eminent psychiatrists tackle the difficult task of reconciling what artists and thinkers have known for thousands of years about the human heart with what has only recently been learned about the primitive functions of the human brain. A General Theory of Love demonstrates that our nervous systems are not self-contained: from earliest childhood, our brains actually link with those of the people close to us, in a silent rhythm that alters the very structure of our brains, establishes life-long emotional patterns, and makes us, in large part, who we are. Explaining how relationships function, how parents shape their child’s developing self, how psychotherapy really works, and how our society dangerously flouts essential emotional laws, this is a work of rare passion and eloquence that will forever change the way you think about human intimacy.
Neuroanatomy is the fundamental cornerstone for understanding nervous system function and dysfunction. This fifth edition continues to provide a succinct, clear and well-illustrated account of the anatomy of the human nervous system.
fMRI Neurofeedback provides a perspective on how the field of functional magnetic resonance imaging (fMRI) neurofeedback has evolved, an introduction to state-of-the-art methods used for fMRI neurofeedback, a review of published neuroscientific and clinical applications, and a discussion of relevant ethical considerations. It gives a view of the ongoing research challenges throughout and provides guidance for researchers new to the field on the practical implementation and design of fMRI neurofeedback protocols. This book is designed to be accessible to all scientists and clinicians interested in conducting fMRI neurofeedback research, addressing the variety of different knowledge gaps that readers may have given their varied backgrounds and avoiding field-specific jargon. The book, therefore, will be suitable for engineers, computer scientists, neuroscientists, psychologists, and physicians working in fMRI neurofeedback. - Provides a reference on fMRI neurofeedback covering history, methods, mechanisms, clinical applications, and basic research, as well as ethical considerations - Offers contributions from international experts—leading research groups are represented, including from Europe, Japan, Israel, and the United States - Includes coverage of data analytic methods, study design, neuroscience mechanisms, and clinical considerations - Presents a perspective on future translational development