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A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
Exploring Lifespan Development, Fourth Edition, the essentials version of Development Through the Lifespan, Seventh Edition by best-selling author Laura E. Berk, includes the same topics, the same number of chapters, and the same outstanding features, with a focus on the most important information and a greater emphasis on practical, real-life applications.
How is each individual's unique personality formed? What is it about p ersonality that can change, and why is change often so slow? Promising approaches to these perennial questions are suggested by the explosio n of recent research in neuroscience and brain functioning. This timel y volume presents a coherent, empirically based, and clinically useful framework for understanding personality. Jim Grigsby and David Steven s illuminate links between the organization of the brain and the unfol ding of personality, and show how different aspects of personality are mediated by the brain's nonconscious learning and memory systems. Pro viding new insights for clinicians, students, and researchers, this bo ok builds a critical bridge between existing psychological theories of personality and emerging knowledge in clinical neuroscience.
M360 is a clinical (treatment rather than theory) approach to health and human performance. We all live by a twenty-four-hour cycle. Sleep is the most important part of that cycle at eight hours, leaving us sixteen hours to master our metabolic fitness for life. M360 is here to facilitate the treatment of our lifestyle, exercise, diet, and stress management. Our metabolism is churning out ATP energy 24-7 to keep us alive and with it, various emissions of inflammation, ROS, and oxidative stress that are promoting heart disease, cancer, and respiratory diseasethe three biggest killers of humankind. We can dramatically alter this course of events and achieve metabolic fitness for life. It all starts with learning, then applying what we learn to bio-hack our metabolism away from being sugar dependent to being fat adapted. We can produce more energy, reduce fat mass, reduce ROS, and live with more power, vitality, and function.
Autism 360 uses a hybrid and transdisciplinary methodology to identify mechanisms on how autism is prevented, diagnosed, treated and managed within personal and social constructs around the world. Adopting a lifespan approach, the book discusses lifestyle challenges and emphasizes issues relating to neurodiversity, individuality, best practices, and support of both people on the spectrum and their families. This book will help change population and individual attitudes and behaviors regarding autism. Its ultimate goal is to empower readers to become both agents of change and an integral part of the solution. - Covers topics from the prevention and treatment of autism and how to live with it - Adopts an integrated methods approach - Features field experiences - Provides valuable syntheses of scattered material - Compares cross-cultural learnings - Discusses the education and employment of those with autism
Doctor Who stories are many things: thrilling adventures, historical dramas, tales of love and war and jelly babies. They’re also science fiction – but how much of the science is actually real, and how much is really fiction? The Scientific Secrets of Doctor Who is a mind-bending blend of story and science that will help you see Doctor Who in a whole new light, weaving together a series of all-new adventures, featuring every incarnation of the Doctor. With commentary that explores the possibilities of time travel, life on other planets, artificial intelligence, parallel universes and more, Simon Guerrier and Dr Marek Kukula show how Doctor Who uses science to inform its unique style of storytelling – and just how close it has often come to predicting future scientific discoveries. This book is your chance to be the Doctor's companion and explore what's out there. It will make you laugh, and think, and see the world around you differently. Because anything could be out there. And going out there is the only way to learn what it is.
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Prepare for success in today's fast-paced, collaborative healthcare environment! Offering expert perspectives from a variety of primary care and nurse practitioners, Primary Care: A Collaborative Practice, 5th Edition helps you diagnose, treat, and manage hundreds of adult disorders. Care recommendations indicate when to consult with physicians or specialists, and when to refer patients to an emergency facility. This edition includes six new chapters, a fresh new design, the latest evidence-based guidelines, and a new emphasis on clinical reasoning. Combining academic and clinical expertise, an author team led by Terry Mahan Buttaro shows NPs how to provide effective, truly interdisciplinary health care. UNIQUE! A collaborative perspective promotes seamless continuity of care, with chapters written by NPs, physicians, PAs, and other primary care providers. Comprehensive, evidence-based content covers every major disorder of adults seen in the outpatient office setting, reflects today's best practices, and includes the knowledge you need for the NP/DNP level of practice. A consistent format in each chapter is used to describe disorders, facilitating easier learning and quick clinical reference. Diagnostics and Differential Diagnosis boxes provide a quick reference for diagnosing disorders and making care management decisions. Complementary and alternative therapies are addressed where supported by solid research evidence. Referral icons highlight situations calling for specialist referral or emergency referral. NEW chapters cover topics including transitional care, risk management, LGBTQ patient care, bullous pemphigoid, pulmonary embolism, and dysphagia. NEW! An emphasis on clinical reasoning helps you develop skills in diagnosis and treatment, with coverage moving away from pathophysiology and toward diagnostic reasoning and disease management — including pharmacologic management. NEW focus on interdisciplinary care underscores the importance of interprofessional education and practice, and includes Interdisciplinary Management features. UPDATED chapters reflect the latest literature and evidence-based treatment guidelines, including new content on the Affordable Care Act as well as new coverage of patient satisfaction metrics, quality metrics, value-based purchasing, pharmacogenetics/genomics, and teen pregnancy and abnormal pregnancy. NEW quick-reference features make it easier to locate important information, through colorful section tabs, bulleted summaries, additional algorithms, a more logical table of contents, an Index to Standardized Treatment Guidelines, and a Reference to Common Laboratory Values.
Promote health and wellness for all ages and population groups! Health Promotion Throughout the Life Span, 9th Edition provides a comprehensive guide to leading health promotion concepts, from assessment to interventions to application. Its lifespan approach addresses patients' unique needs with case studies and care plans, with an assessment framework based on Gordon's Functional Health Patterns. New to this edition is expanded coverage of genomics and QSEN competencies. Written by nursing experts Carole Edelman and Elizabeth Kudzma, this bestselling text covers all the latest research and trends in health promotion and disease prevention. - Separate chapters on population groups — the individual, family, and community — highlight the unique aspects of assessment and health promotion for each group. - Coverage of growth and development helps you apply health promotion concepts to each age and each stage of development through the lifespan. - Case studies present realistic situations with questions asking you to apply key concepts, and care plans include nursing diagnoses, defining characteristics, related factors, expected outcomes, and interventions. - Quality and Safety Scenario boxes focus on QSEN-related competencies with examples of health promotion. - Innovative Practice boxes outline unique and creative health promotion programs and projects currently being implemented. - Healthy People 2020 boxes present goals and objectives relating to national health issues and priorities. - Research for Evidence-Based Practice boxes summarize current health-promotion studies showing the links between research, theory, and practice. - Diversity Awareness boxes address cultural perspectives relating to planning care. - Hot Topics boxes introduce significant issues, trends, and controversies in health promotion. - Think About It clinical scenarios open each chapter, and include questions to encourage critical thinking. - NEW! An increased focus on genomics reflects scientific evidence supporting the use of genetic tests and family health history to guide public health interventions. - NEW! Expanded discussion of QSEN competencies is included, as related to health promotion. - NEW! Guidelines and recommendations are included from the latest Guide to Clinical Preventive Services from the U.S. Preventive Services Task Force. - NEW! The latest information about the Affordable Care Act is included. - NEW! Updated photos reflect the latest in health promotion and disease prevention.